FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011330790> ?p ?o ?g. }

• W3011330790 endingPage "629" @default.
• W3011330790 startingPage "619" @default.
• W3011330790 abstract "Background/Aims Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that plays a key role in Th2-mediated inflammation, both directly by promoting the proliferation of naïve CD4 Th2 cells, and indirectly by activating dendritic cells (DCs). TSLP-activated DCs induce the expansion of chemoattractant receptor homologous molecule expressed on Th2 (CRTH2)+ CD4+ Th2 memory cells, which undergo a Th2 response and express prostaglandin D2 (PGD2) synthase. CRTH2, a PGD2 receptor, is a selective Th2-cell surface marker. We investigated the effects of an anti-TSLP antibody (Ab) and a CRTH2 antagonist, as well as their mechanisms of action, in a mouse model of acute asthma. Methods BALB/c mice were sensitized and challenged with ovalbumin. We then evaluated the effects of the administration of an anti-TSLP Ab either alone or together with a CRTH2 antagonist on cell counts, Th2 cytokine levels in bronchoalveolar fluid, and the levels of epithelium-derived cytokines such as TSLP, interleukin (IL) 33, and IL-25 in lung homogenates, as well as airway hyper-responsiveness (AHR). Results Anti-TSLP Ab and the CRTH2 antagonist significantly attenuated eosinophilic airway inflammation, AHR, and the expression of Th2 cytokines. The expression of GATA-3 and the levels of IL-33 and IL-25 in lung tissues were affected by the combined anti-TSLP and CRTH2 antagonist treatment. Conclusions These results suggest that the dual blockade of TSLP and CRTH2 may serve as an effective treatment target for eosinophilic asthma." @default.
• W3011330790 created "2020-03-23" @default.
• W3011330790 creator A5000364219 @default.
• W3011330790 creator A5009253664 @default.
• W3011330790 creator A5022028206 @default.
• W3011330790 creator A5023939307 @default.
• W3011330790 creator A5026205790 @default.
• W3011330790 creator A5034381454 @default.
• W3011330790 creator A5040057122 @default.
• W3011330790 creator A5061037103 @default.
• W3011330790 creator A5083765336 @default.
• W3011330790 date "2020-05-01" @default.
• W3011330790 modified "2023-10-17" @default.
• W3011330790 title "Blockade of thymic stromal lymphopoietin and CRTH2 attenuates airway inflammation in a murine model of allergic asthma" @default.
• W3011330790 cites W1583517745 @default.
• W3011330790 cites W1859491149 @default.
• W3011330790 cites W1968204922 @default.
• W3011330790 cites W1987492687 @default.
• W3011330790 cites W1988848855 @default.
• W3011330790 cites W1994569436 @default.
• W3011330790 cites W2001835698 @default.
• W3011330790 cites W2007953494 @default.
• W3011330790 cites W2009357776 @default.
• W3011330790 cites W2018704729 @default.
• W3011330790 cites W2019881908 @default.
• W3011330790 cites W2023719946 @default.
• W3011330790 cites W2027699993 @default.
• W3011330790 cites W2027746633 @default.
• W3011330790 cites W2046843609 @default.
• W3011330790 cites W2050706371 @default.
• W3011330790 cites W2053894571 @default.
• W3011330790 cites W2057450814 @default.
• W3011330790 cites W2060202956 @default.
• W3011330790 cites W2067223664 @default.
• W3011330790 cites W2068870295 @default.
• W3011330790 cites W2073939652 @default.
• W3011330790 cites W2077941293 @default.
• W3011330790 cites W2079341044 @default.
• W3011330790 cites W2100705331 @default.
• W3011330790 cites W2107553722 @default.
• W3011330790 cites W2126208157 @default.
• W3011330790 cites W2135516248 @default.
• W3011330790 cites W2135790224 @default.
• W3011330790 cites W2136199835 @default.
• W3011330790 cites W2140299259 @default.
• W3011330790 cites W2141752230 @default.
• W3011330790 cites W2142746235 @default.
• W3011330790 cites W2158108461 @default.
• W3011330790 cites W2165438365 @default.
• W3011330790 cites W2289369304 @default.
• W3011330790 cites W2475158269 @default.
• W3011330790 cites W2599852731 @default.
• W3011330790 cites W2620841583 @default.
• W3011330790 cites W2752584372 @default.
• W3011330790 cites W2779261498 @default.
• W3011330790 cites W2791453916 @default.
• W3011330790 cites W4229854192 @default.
• W3011330790 doi "https://doi.org/10.3904/kjim.2018.248" @default.
• W3011330790 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7214371" @default.
• W3011330790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32183504" @default.
• W3011330790 hasPublicationYear "2020" @default.
• W3011330790 type Work @default.
• W3011330790 sameAs 3011330790 @default.
• W3011330790 citedByCount "6" @default.
• W3011330790 countsByYear W30113307902021 @default.
• W3011330790 countsByYear W30113307902022 @default.
• W3011330790 countsByYear W30113307902023 @default.
• W3011330790 crossrefType "journal-article" @default.
• W3011330790 hasAuthorship W3011330790A5000364219 @default.
• W3011330790 hasAuthorship W3011330790A5009253664 @default.
• W3011330790 hasAuthorship W3011330790A5022028206 @default.
• W3011330790 hasAuthorship W3011330790A5023939307 @default.
• W3011330790 hasAuthorship W3011330790A5026205790 @default.
• W3011330790 hasAuthorship W3011330790A5034381454 @default.
• W3011330790 hasAuthorship W3011330790A5040057122 @default.
• W3011330790 hasAuthorship W3011330790A5061037103 @default.
• W3011330790 hasAuthorship W3011330790A5083765336 @default.
• W3011330790 hasBestOaLocation W30113307901 @default.
• W3011330790 hasConcept C126322002 @default.
• W3011330790 hasConcept C170493617 @default.
• W3011330790 hasConcept C203014093 @default.
• W3011330790 hasConcept C2776885963 @default.
• W3011330790 hasConcept C2776914184 @default.
• W3011330790 hasConcept C2776946954 @default.
• W3011330790 hasConcept C2777361909 @default.
• W3011330790 hasConcept C2778070265 @default.
• W3011330790 hasConcept C2778122271 @default.
• W3011330790 hasConcept C2778690821 @default.
• W3011330790 hasConcept C2779675166 @default.
• W3011330790 hasConcept C71924100 @default.
• W3011330790 hasConcept C8891405 @default.
• W3011330790 hasConceptScore W3011330790C126322002 @default.
• W3011330790 hasConceptScore W3011330790C170493617 @default.
• W3011330790 hasConceptScore W3011330790C203014093 @default.
• W3011330790 hasConceptScore W3011330790C2776885963 @default.
• W3011330790 hasConceptScore W3011330790C2776914184 @default.
• W3011330790 hasConceptScore W3011330790C2776946954 @default.
• W3011330790 hasConceptScore W3011330790C2777361909 @default.

• next