Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011377285> ?p ?o ?g. }
- W3011377285 endingPage "459" @default.
- W3011377285 startingPage "449" @default.
- W3011377285 abstract "Smart phase transformation systems@hard capsule (SPTS@hard capsule) based on lyotropic liquid crystalline (LLC) were developed for oral sustained release in this study. Doxycycline hydrochloride (DOXY) and meloxicam (MLX) were used as hydrophilic and hydrophobic model drug, respectively. Two systems were added with different additives, that is, gelucire 39/01, PEG 1000 and Tween 80 to adjust their melting point and release profiles. The phase transformation of these systems could be triggered by water as well as temperature. They could spontaneously transform into cubic phase or hexagonal phase when coming across with water, to achieve the 24 h sustained release profile. In addition, the obtained systems could switch between semisolid state and liquid state when temperature changed within room temperature and body temperature, which facilitated the phase transformation in gastrointestinal tract and during their encapsulation into hard capsules. LLC-based SPTS@hard capsule revealed potential for the industrialization of its oral administration on account of its drugs accommodation with different solubility, controllable release profile and simple preparation process." @default.
- W3011377285 created "2020-03-23" @default.
- W3011377285 creator A5002586556 @default.
- W3011377285 creator A5004780987 @default.
- W3011377285 creator A5020448985 @default.
- W3011377285 creator A5030428536 @default.
- W3011377285 creator A5032087327 @default.
- W3011377285 creator A5044053727 @default.
- W3011377285 creator A5048395591 @default.
- W3011377285 creator A5082177178 @default.
- W3011377285 creator A5089480544 @default.
- W3011377285 date "2020-01-01" @default.
- W3011377285 modified "2023-10-16" @default.
- W3011377285 title "Smart phase transformation system based on lyotropic liquid crystalline@hard capsules for sustained release of hydrophilic and hydrophobic drugs" @default.
- W3011377285 cites W1006649906 @default.
- W3011377285 cites W162775971 @default.
- W3011377285 cites W1700058403 @default.
- W3011377285 cites W1923467661 @default.
- W3011377285 cites W1989295556 @default.
- W3011377285 cites W2019873852 @default.
- W3011377285 cites W2030860750 @default.
- W3011377285 cites W2032587917 @default.
- W3011377285 cites W2037608127 @default.
- W3011377285 cites W2044094150 @default.
- W3011377285 cites W2074742730 @default.
- W3011377285 cites W2076826185 @default.
- W3011377285 cites W2092163118 @default.
- W3011377285 cites W2106160805 @default.
- W3011377285 cites W2122635512 @default.
- W3011377285 cites W2136285383 @default.
- W3011377285 cites W2154663309 @default.
- W3011377285 cites W2161914831 @default.
- W3011377285 cites W2179709362 @default.
- W3011377285 cites W2199737074 @default.
- W3011377285 cites W2238951274 @default.
- W3011377285 cites W2318716278 @default.
- W3011377285 cites W2343069811 @default.
- W3011377285 cites W2588952947 @default.
- W3011377285 cites W2594581171 @default.
- W3011377285 cites W2605563843 @default.
- W3011377285 cites W2748920214 @default.
- W3011377285 cites W2762189082 @default.
- W3011377285 cites W2772341622 @default.
- W3011377285 cites W2775226387 @default.
- W3011377285 cites W2782811984 @default.
- W3011377285 cites W2785425758 @default.
- W3011377285 cites W2789253582 @default.
- W3011377285 cites W2789628002 @default.
- W3011377285 cites W2790156910 @default.
- W3011377285 cites W2807541499 @default.
- W3011377285 cites W2900085520 @default.
- W3011377285 cites W2900871597 @default.
- W3011377285 cites W2941513716 @default.
- W3011377285 cites W2943956289 @default.
- W3011377285 cites W4239201894 @default.
- W3011377285 doi "https://doi.org/10.1080/10717544.2020.1736210" @default.
- W3011377285 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7144316" @default.
- W3011377285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32157918" @default.
- W3011377285 hasPublicationYear "2020" @default.
- W3011377285 type Work @default.
- W3011377285 sameAs 3011377285 @default.
- W3011377285 citedByCount "10" @default.
- W3011377285 countsByYear W30113772852020 @default.
- W3011377285 countsByYear W30113772852021 @default.
- W3011377285 countsByYear W30113772852022 @default.
- W3011377285 countsByYear W30113772852023 @default.
- W3011377285 crossrefType "journal-article" @default.
- W3011377285 hasAuthorship W3011377285A5002586556 @default.
- W3011377285 hasAuthorship W3011377285A5004780987 @default.
- W3011377285 hasAuthorship W3011377285A5020448985 @default.
- W3011377285 hasAuthorship W3011377285A5030428536 @default.
- W3011377285 hasAuthorship W3011377285A5032087327 @default.
- W3011377285 hasAuthorship W3011377285A5044053727 @default.
- W3011377285 hasAuthorship W3011377285A5048395591 @default.
- W3011377285 hasAuthorship W3011377285A5082177178 @default.
- W3011377285 hasAuthorship W3011377285A5089480544 @default.
- W3011377285 hasBestOaLocation W30113772851 @default.
- W3011377285 hasConcept C127413603 @default.
- W3011377285 hasConcept C148280534 @default.
- W3011377285 hasConcept C155574463 @default.
- W3011377285 hasConcept C159985019 @default.
- W3011377285 hasConcept C178790620 @default.
- W3011377285 hasConcept C185592680 @default.
- W3011377285 hasConcept C192562407 @default.
- W3011377285 hasConcept C2778778583 @default.
- W3011377285 hasConcept C2994273327 @default.
- W3011377285 hasConcept C42360764 @default.
- W3011377285 hasConcept C44280652 @default.
- W3011377285 hasConcept C521977710 @default.
- W3011377285 hasConcept C59822182 @default.
- W3011377285 hasConcept C86803240 @default.
- W3011377285 hasConcept C88380143 @default.
- W3011377285 hasConceptScore W3011377285C127413603 @default.
- W3011377285 hasConceptScore W3011377285C148280534 @default.
- W3011377285 hasConceptScore W3011377285C155574463 @default.
- W3011377285 hasConceptScore W3011377285C159985019 @default.
- W3011377285 hasConceptScore W3011377285C178790620 @default.
- W3011377285 hasConceptScore W3011377285C185592680 @default.