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- W3011394886 abstract "Morphological parameters of biological nanoparticles (BNPs) have strong implications on their fate and functionality in vivo e.g., circulation, biodistribution, and clearance. Although interferometric scattering microscopy modalities have demonstrated the label-free detection of sub-100 nm BNPs including viruses and exosomes; they have an insufficient spatial resolution roughly limited to the illumination wavelength. Here, we introduce computational imaging to interferometric scattering microscopy with asymmetric illumination and demonstrate a two-fold resolution enhancement. We demonstrate high-resolution imaging of nanoparticles across a large field-of-view of 100 µm × 100 µm. This novel imaging platform enables ultrasensitive and label-free morphological visualization of low-index sub-diffraction-limited BNPs in a high-throughput manner at subwavelength resolution." @default.
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- W3011394886 date "2020-03-10" @default.
- W3011394886 modified "2023-09-26" @default.
- W3011394886 title "High-throughput and label-free imaging of individual biological nanoparticles at high-resolution (Conference Presentation)" @default.
- W3011394886 doi "https://doi.org/10.1117/12.2545232" @default.
- W3011394886 hasPublicationYear "2020" @default.
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