FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011404904> ?p ?o ?g. }

• W3011404904 endingPage "208" @default.
• W3011404904 startingPage "198" @default.
• W3011404904 abstract "Summary Serial assessments of measurable (or minimal) residual disease (MRD) by qPCR may identify nascent relapse in children with acute myeloid leukaemia (AML) and enable pre‐emptive therapy. We investigated the kinetics and prognostic impact of recurrent fusion transcripts ( RUNX1‐RUNX1T1, CBFB‐MYH11, KMT2A‐MLLT3 or KMT2A‐ELL ) in 774 post‐induction samples from bone marrow (BM, 347) and peripheral blood (PB, 427) from 75 children with AML. BM MRD persistence during consolidation did not increase the risk of relapse, and MRD at therapy completion did not correlate to outcome (HR = 0·64/MRD log reduction (CI: 0·32–1·26), P = 0·19). In contrast, 8/8 patients with detectable MRD in PB after first consolidation relapsed. Persistence ( n = 4) and shifting from negative to positive ( n = 10) in PB during follow‐up predicted relapse in 14/14 patients. All 253 PB samples collected during follow‐up from 36 patients in continuous complete remission were MRD negative. In core‐binding factor AML, persistent low‐level MRD positivity in BM during follow‐up was frequent but an increment to above 5 × 10 −4 heralded subsequent haematological relapse in 12/12 patients. We demonstrate that MRD monitoring in PB after induction therapy is highly informative and propose an MRD increment above 5 × 10 −4 in PB and BM as a definition of molecular relapse since it always leads to haematological relapse." @default.
• W3011404904 created "2020-03-23" @default.
• W3011404904 creator A5009353735 @default.
• W3011404904 creator A5017434280 @default.
• W3011404904 creator A5021059631 @default.
• W3011404904 creator A5023422397 @default.
• W3011404904 creator A5026844718 @default.
• W3011404904 creator A5030520638 @default.
• W3011404904 creator A5037364159 @default.
• W3011404904 creator A5057818328 @default.
• W3011404904 creator A5062007984 @default.
• W3011404904 creator A5066050875 @default.
• W3011404904 creator A5076309463 @default.
• W3011404904 creator A5076502958 @default.
• W3011404904 creator A5077898714 @default.
• W3011404904 creator A5078544325 @default.
• W3011404904 creator A5090910971 @default.
• W3011404904 date "2020-03-16" @default.
• W3011404904 modified "2023-10-06" @default.
• W3011404904 title "Measurable residual disease assessment by qPCR in peripheral blood is an informative tool for disease surveillance in childhood acute myeloid leukaemia" @default.
• W3011404904 cites W1531055081 @default.
• W3011404904 cites W1966887150 @default.
• W3011404904 cites W1969017771 @default.
• W3011404904 cites W1977985381 @default.
• W3011404904 cites W1984658294 @default.
• W3011404904 cites W2003186972 @default.
• W3011404904 cites W2003664440 @default.
• W3011404904 cites W2005410572 @default.
• W3011404904 cites W2007302457 @default.
• W3011404904 cites W2010571787 @default.
• W3011404904 cites W2021663709 @default.
• W3011404904 cites W2026826794 @default.
• W3011404904 cites W2036862498 @default.
• W3011404904 cites W2075902150 @default.
• W3011404904 cites W2076208040 @default.
• W3011404904 cites W2084299345 @default.
• W3011404904 cites W2098787760 @default.
• W3011404904 cites W2118250079 @default.
• W3011404904 cites W2138394378 @default.
• W3011404904 cites W2141324982 @default.
• W3011404904 cites W2152182390 @default.
• W3011404904 cites W2153994826 @default.
• W3011404904 cites W2163358530 @default.
• W3011404904 cites W2168480534 @default.
• W3011404904 cites W2184458350 @default.
• W3011404904 cites W2193395909 @default.
• W3011404904 cites W2276580523 @default.
• W3011404904 cites W2336690489 @default.
• W3011404904 cites W2592430869 @default.
• W3011404904 cites W2625099017 @default.
• W3011404904 cites W273386428 @default.
• W3011404904 cites W2783450169 @default.
• W3011404904 cites W2901332394 @default.
• W3011404904 cites W2975689185 @default.
• W3011404904 cites W4301861531 @default.
• W3011404904 cites W990603645 @default.
• W3011404904 doi "https://doi.org/10.1111/bjh.16560" @default.
• W3011404904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32175599" @default.
• W3011404904 hasPublicationYear "2020" @default.
• W3011404904 type Work @default.
• W3011404904 sameAs 3011404904 @default.
• W3011404904 citedByCount "13" @default.
• W3011404904 countsByYear W30114049042021 @default.
• W3011404904 countsByYear W30114049042022 @default.
• W3011404904 countsByYear W30114049042023 @default.
• W3011404904 crossrefType "journal-article" @default.
• W3011404904 hasAuthorship W3011404904A5009353735 @default.
• W3011404904 hasAuthorship W3011404904A5017434280 @default.
• W3011404904 hasAuthorship W3011404904A5021059631 @default.
• W3011404904 hasAuthorship W3011404904A5023422397 @default.
• W3011404904 hasAuthorship W3011404904A5026844718 @default.
• W3011404904 hasAuthorship W3011404904A5030520638 @default.
• W3011404904 hasAuthorship W3011404904A5037364159 @default.
• W3011404904 hasAuthorship W3011404904A5057818328 @default.
• W3011404904 hasAuthorship W3011404904A5062007984 @default.
• W3011404904 hasAuthorship W3011404904A5066050875 @default.
• W3011404904 hasAuthorship W3011404904A5076309463 @default.
• W3011404904 hasAuthorship W3011404904A5076502958 @default.
• W3011404904 hasAuthorship W3011404904A5077898714 @default.
• W3011404904 hasAuthorship W3011404904A5078544325 @default.
• W3011404904 hasAuthorship W3011404904A5090910971 @default.
• W3011404904 hasBestOaLocation W30114049041 @default.
• W3011404904 hasConcept C126322002 @default.
• W3011404904 hasConcept C143998085 @default.
• W3011404904 hasConcept C203014093 @default.
• W3011404904 hasConcept C2779282312 @default.
• W3011404904 hasConcept C2779823535 @default.
• W3011404904 hasConcept C2780007613 @default.
• W3011404904 hasConcept C2993296363 @default.
• W3011404904 hasConcept C71924100 @default.
• W3011404904 hasConcept C90924648 @default.
• W3011404904 hasConceptScore W3011404904C126322002 @default.
• W3011404904 hasConceptScore W3011404904C143998085 @default.
• W3011404904 hasConceptScore W3011404904C203014093 @default.
• W3011404904 hasConceptScore W3011404904C2779282312 @default.
• W3011404904 hasConceptScore W3011404904C2779823535 @default.
• W3011404904 hasConceptScore W3011404904C2780007613 @default.
• W3011404904 hasConceptScore W3011404904C2993296363 @default.

• next