FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011440530> ?p ?o ?g. }

• W3011440530 abstract "Upregulation of the six-transmembrane epithelial antigen of prostate-1 (STEAP1) is closely associated with prognosis of numerous malignant cancers. However, its role in lung adenocarcinoma (LUAD), the most common type of lung cancer, remains unknown. This study aimed to investigate the role of STEAP1 in the occurrence and progression of LUAD and the potential mechanisms underlying its regulatory effects.STEAP1 mRNA and protein expression were analyzed in 40 LUAD patients via real-time PCR and western blotting, respectively. We accessed the clinical data of 522 LUAD patients from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) to investigate the expression and prognostic role of STEAP1 in LUAD. Further, we performed gene ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and gene set enrichment analysis (GSEA) to elucidate the potential mechanism underlying the role of STEAP1 in LUAD. The protein-protein interaction (PPI) network of STEAP1 was analyzed using the Search Tool for the Retrieval of Interacting Genes (STRING) database, and hub genes with significant positive and negative associations with STEAP1 were identified and their role in LUAD prognosis was predicted.STEAP1 was significantly upregulated in LUAD patients and associated with LUAD prognosis. Further, TCGA data indicated that STEAP1 upregulation is correlated with the clinical prognosis of LUAD. GO and KEGG analysis revealed that the genes co-expressed with STEAP1 were primarily involved in cell division, DNA replication, cell cycle, apoptosis, cytokine signaling, NF-kB signaling, and TNF signaling. GSEA revealed that homologous recombination, p53 signaling pathway, cell cycle, DNA replication, apoptosis, and toll-like receptor signaling were highly enriched upon STEAP1 upregulation. Gene Expression Profiling Interactive Analysis (GEPIA) analysis revealed that the top 10 hub genes associated with STEAP1 expression were also associated with the LUAD prognosis.STEAP1 upregulation potentially influences the occurrence and progression of LUAD and its co-expressed genes via regulation of homologous recombination, p53 signaling, cell cycle, DNA replication, and apoptosis. STEAP1 is a potential prognostic biomarker for LUAD." @default.
• W3011440530 created "2020-03-23" @default.
• W3011440530 creator A5000750700 @default.
• W3011440530 creator A5023912850 @default.
• W3011440530 creator A5029196561 @default.
• W3011440530 creator A5034707336 @default.
• W3011440530 creator A5037536319 @default.
• W3011440530 creator A5047147000 @default.
• W3011440530 creator A5059361862 @default.
• W3011440530 creator A5071407360 @default.
• W3011440530 creator A5072580346 @default.
• W3011440530 creator A5087310769 @default.
• W3011440530 date "2020-03-20" @default.
• W3011440530 modified "2023-10-17" @default.
• W3011440530 title "Evaluation of the Prognostic Value of STEAP1 in Lung Adenocarcinoma and Insights Into Its Potential Molecular Pathways via Bioinformatic Analysis" @default.
• W3011440530 cites W1975610085 @default.
• W3011440530 cites W1977353424 @default.
• W3011440530 cites W1988936541 @default.
• W3011440530 cites W1995936302 @default.
• W3011440530 cites W2002381200 @default.
• W3011440530 cites W2046605403 @default.
• W3011440530 cites W2047467092 @default.
• W3011440530 cites W2050189130 @default.
• W3011440530 cites W2054841768 @default.
• W3011440530 cites W2063134389 @default.
• W3011440530 cites W2069378748 @default.
• W3011440530 cites W2096173332 @default.
• W3011440530 cites W2107959310 @default.
• W3011440530 cites W2128154694 @default.
• W3011440530 cites W2336876962 @default.
• W3011440530 cites W2512447048 @default.
• W3011440530 cites W2571282838 @default.
• W3011440530 cites W2607129810 @default.
• W3011440530 cites W2610868722 @default.
• W3011440530 cites W2621543314 @default.
• W3011440530 cites W2746213083 @default.
• W3011440530 cites W2756246142 @default.
• W3011440530 cites W2788740682 @default.
• W3011440530 cites W2794520086 @default.
• W3011440530 cites W2794851756 @default.
• W3011440530 cites W2799785541 @default.
• W3011440530 cites W2883922109 @default.
• W3011440530 cites W2886130335 @default.
• W3011440530 cites W2889045794 @default.
• W3011440530 cites W2889646458 @default.
• W3011440530 cites W2891669485 @default.
• W3011440530 cites W2895802174 @default.
• W3011440530 cites W2899519291 @default.
• W3011440530 cites W2900925432 @default.
• W3011440530 cites W2911989347 @default.
• W3011440530 cites W2928665623 @default.
• W3011440530 cites W2929096175 @default.
• W3011440530 cites W2929363766 @default.
• W3011440530 cites W2942859722 @default.
• W3011440530 cites W2944159979 @default.
• W3011440530 cites W2971485541 @default.
• W3011440530 cites W2984535964 @default.
• W3011440530 cites W3004626105 @default.
• W3011440530 cites W4288400169 @default.
• W3011440530 doi "https://doi.org/10.3389/fgene.2020.00242" @default.
• W3011440530 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7099762" @default.
• W3011440530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32265985" @default.
• W3011440530 hasPublicationYear "2020" @default.
• W3011440530 type Work @default.
• W3011440530 sameAs 3011440530 @default.
• W3011440530 citedByCount "22" @default.
• W3011440530 countsByYear W30114405302020 @default.
• W3011440530 countsByYear W30114405302021 @default.
• W3011440530 countsByYear W30114405302022 @default.
• W3011440530 countsByYear W30114405302023 @default.
• W3011440530 crossrefType "journal-article" @default.
• W3011440530 hasAuthorship W3011440530A5000750700 @default.
• W3011440530 hasAuthorship W3011440530A5023912850 @default.
• W3011440530 hasAuthorship W3011440530A5029196561 @default.
• W3011440530 hasAuthorship W3011440530A5034707336 @default.
• W3011440530 hasAuthorship W3011440530A5037536319 @default.
• W3011440530 hasAuthorship W3011440530A5047147000 @default.
• W3011440530 hasAuthorship W3011440530A5059361862 @default.
• W3011440530 hasAuthorship W3011440530A5071407360 @default.
• W3011440530 hasAuthorship W3011440530A5072580346 @default.
• W3011440530 hasAuthorship W3011440530A5087310769 @default.
• W3011440530 hasBestOaLocation W30114405301 @default.
• W3011440530 hasConcept C104317684 @default.
• W3011440530 hasConcept C121608353 @default.
• W3011440530 hasConcept C127561419 @default.
• W3011440530 hasConcept C150194340 @default.
• W3011440530 hasConcept C152724338 @default.
• W3011440530 hasConcept C162317418 @default.
• W3011440530 hasConcept C2781018059 @default.
• W3011440530 hasConcept C2781182431 @default.
• W3011440530 hasConcept C29537977 @default.
• W3011440530 hasConcept C502942594 @default.
• W3011440530 hasConcept C54355233 @default.
• W3011440530 hasConcept C62478195 @default.
• W3011440530 hasConcept C86803240 @default.
• W3011440530 hasConceptScore W3011440530C104317684 @default.
• W3011440530 hasConceptScore W3011440530C121608353 @default.
• W3011440530 hasConceptScore W3011440530C127561419 @default.
• W3011440530 hasConceptScore W3011440530C150194340 @default.
• W3011440530 hasConceptScore W3011440530C152724338 @default.

• next