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• W3011489074 abstract "This study aims to determine the influence of unilateral chewing on metabolic characteristics of masseter muscle fibers in rats and the regulatory effect of an adenosine monophosphate activated protein kinase (AMPK) signal pathway on metabolism.Rats were submitted to exodontia of all the right maxillary molars and divided into 2, 4, 6, and 8 weeks groups, and corresponding control groups were set as well. Sections were stained by nicotine adenine dinucleotide tetrazolim reductase(NADH-TRase) to demonstrate the types, proportion, and density of masseter muscle fibers. AMPKα1 and p-AMPK(Thr172) levels in bilateral masseter muscles were detected by Western blot.In the 2-week group, the percentage of dark fibers augmented in the ipsilateral side, whereas the percentage of intermediary fibers in the contralateral side was increased accompanied by a decrease of light fibers, compared with the control group (P<0.05). The percentage of dark fibers was increased in the bilateral sides, whereas the percentage of dark fiber in the ipsilateral sides surpassed that of the contralateral sides in the 4, 6, and 8-week groups. The percentage of intermediary fibers was decreased in the bilateral sides in the 6 and 8-week groups (P<0.05). The percentage of light fibers was reduced in the ipsilateral sides in the 8-week group, whereas no alteration was observed in contralateral sides (P>0.05). In the ipsilateral sides, p-AMPK (Thr172)/AMPKα1 levels were increased in the 2 and 4-week groups (P<0.05), whereas no change was observed in the contralateral sides in either group (P>0.05).Unilateral chewing increases the oxidative metabolic ability in bilateral masseter muscle fibers especially in the non-working side accompanied with change of muscle fiber types. The improvement of aerobic metabolism ability is related to the AMPK signal pathway. .目的 探讨偏侧咀嚼对大鼠咬肌肌纤维代谢特征的影响及腺苷酸活化蛋白激酶（AMPK）对肌纤维代谢特征变化的调控作用。方法 拔除大鼠右上颌磨牙建立偏侧咀嚼大鼠模型，实验组分为2、4、6、8周组，设同期对照组。应用辅酶Ⅰ-四氮唑还原酶（NADH-TRase）染色法检测咬肌肌纤维有氧代谢类型以及各型肌纤维的分布密度和构成比；用Western blot技术检测p-AMPK（Thr172）/AMPKα1表达水平。结果 与同期对照组比较，建模2周实验组拔牙侧深染型肌纤维比例增多，非拔牙侧中染型纤维比例增加，浅染型肌纤维比例减少（P<0.05）；建模4、6、8周组双侧深染型肌纤维比例持续增加，拔牙侧显著高于非拔牙侧；第6、8周组双侧中染型肌纤维比例下降（P<0.05）；拔牙侧浅染肌纤维比例在8周组减少，非拔牙侧无明显改变（P>0.05）。p-AMPK（Thr172）/AMPKα1表达水平在2、4周拔牙侧较对照组和非拔牙侧增高（P<0.05），在非拔牙侧各周组无显著改变（P>0.05）。结论 偏侧咀嚼可促进双侧咬肌肌纤维有氧代谢能力且伴随表型特征的改变，在非工作侧更明显；肌纤维有氧代谢能力增强与AMPK通路的激活有关。." @default.
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• W3011489074 date "2017-06-01" @default.
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• W3011489074 title "[Alteration of metabolic characteristics on the masseter muscle fiber of unilateral chewing rats and its adenosine monophosphate activated protein kinase regulatory mechanism]." @default.
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• W3011489074 doi "https://doi.org/10.7518/hxkq.2017.03.006" @default.
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