FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011492883> ?p ?o ?g. }

• W3011492883 abstract "Abstract Background MicroRNAs (miRNAs) have been investigated in various cardiovascular diseases. As a fatal disease, acute myocardial infarction (AMI) is a serious global health burden. The purpose of this study was to investigate the role of miR-32-5p in AMI patients and human umbilical vein endothelial cells (HUVECs) to explore novel diagnostic and therapeutic approaches for AMI. Methods A target prediction tool miRanda and the luciferase activity assay were used to confirm the interaction of miR-32-5p with Kruppel-like factor 2 (KLF2). Effect of miR-32-5p on HUVECs viability was examined using CCK-8 assay. Serum miR-32-5p expression was measured using quantitative Real-Time PCR, and its correlation with myocardial damage and endothelial injury markers and pro-inflammatory cytokines was assessed. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic value of miR-32-5p in AMI patients. Results miR-32-5p, as a direct regulator of KLF2, could suppress the cell proliferation of HUVECs. Serum miR-32-5p expression was elevated in AMI patients and positively correlated with the biomarker levels of myocardial damage and endothelial injury and pro-inflammatory cytokines. The area under the ROC curve for miR-32-5p was 0.949, indicating the relatively high diagnostic accuracy of miR-32-5p in AMI patients. Conclusion The data of this study revealed that the increased serum miR-32-5p expression serves as a candidate diagnostic biomarker of AMI, and that miR-32-5p may be involved in the myocardial damage, endothelial injury and inflammatory responses of AMI by targeting KLF2, indicating the potential of miR-32-5p as a diagnostic biomarker and molecular target to improve the treatment of AMI." @default.
• W3011492883 created "2020-03-23" @default.
• W3011492883 creator A5009066368 @default.
• W3011492883 creator A5066977109 @default.
• W3011492883 creator A5073661496 @default.
• W3011492883 date "2020-03-03" @default.
• W3011492883 modified "2023-10-03" @default.
• W3011492883 title "Silence of miR-32-5p promotes endothelial cell viability by targeting KLF2 and serves as a diagnostic biomarker of acute myocardial infarction" @default.
• W3011492883 cites W1605677724 @default.
• W3011492883 cites W1897450905 @default.
• W3011492883 cites W2030487571 @default.
• W3011492883 cites W2133546870 @default.
• W3011492883 cites W2169735148 @default.
• W3011492883 cites W2346574112 @default.
• W3011492883 cites W2473268362 @default.
• W3011492883 cites W2518299631 @default.
• W3011492883 cites W2563670936 @default.
• W3011492883 cites W2587344342 @default.
• W3011492883 cites W2588417600 @default.
• W3011492883 cites W2588645651 @default.
• W3011492883 cites W2598171707 @default.
• W3011492883 cites W2599464159 @default.
• W3011492883 cites W2600586351 @default.
• W3011492883 cites W2626034093 @default.
• W3011492883 cites W2735943567 @default.
• W3011492883 cites W2765342097 @default.
• W3011492883 cites W2765788052 @default.
• W3011492883 cites W2765843771 @default.
• W3011492883 cites W2767983047 @default.
• W3011492883 cites W2775506761 @default.
• W3011492883 cites W2784299734 @default.
• W3011492883 cites W2793623478 @default.
• W3011492883 cites W2806060977 @default.
• W3011492883 cites W2896338168 @default.
• W3011492883 cites W2903356278 @default.
• W3011492883 cites W2969713082 @default.
• W3011492883 cites W2981264657 @default.
• W3011492883 cites W3013076131 @default.
• W3011492883 cites W3024713968 @default.
• W3011492883 cites W4205653014 @default.
• W3011492883 cites W4211104669 @default.
• W3011492883 cites W4242336664 @default.
• W3011492883 doi "https://doi.org/10.1186/s13000-020-00942-y" @default.
• W3011492883 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7053100" @default.
• W3011492883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32127011" @default.
• W3011492883 hasPublicationYear "2020" @default.
• W3011492883 type Work @default.
• W3011492883 sameAs 3011492883 @default.
• W3011492883 citedByCount "21" @default.
• W3011492883 countsByYear W30114928832020 @default.
• W3011492883 countsByYear W30114928832021 @default.
• W3011492883 countsByYear W30114928832022 @default.
• W3011492883 countsByYear W30114928832023 @default.
• W3011492883 crossrefType "journal-article" @default.
• W3011492883 hasAuthorship W3011492883A5009066368 @default.
• W3011492883 hasAuthorship W3011492883A5066977109 @default.
• W3011492883 hasAuthorship W3011492883A5073661496 @default.
• W3011492883 hasBestOaLocation W30114928831 @default.
• W3011492883 hasConcept C104317684 @default.
• W3011492883 hasConcept C126322002 @default.
• W3011492883 hasConcept C127561419 @default.
• W3011492883 hasConcept C142724271 @default.
• W3011492883 hasConcept C145059251 @default.
• W3011492883 hasConcept C164705383 @default.
• W3011492883 hasConcept C202751555 @default.
• W3011492883 hasConcept C2776914184 @default.
• W3011492883 hasConcept C2776992346 @default.
• W3011492883 hasConcept C2777350992 @default.
• W3011492883 hasConcept C2777411675 @default.
• W3011492883 hasConcept C2781197716 @default.
• W3011492883 hasConcept C500558357 @default.
• W3011492883 hasConcept C55493867 @default.
• W3011492883 hasConcept C58471807 @default.
• W3011492883 hasConcept C71924100 @default.
• W3011492883 hasConcept C86803240 @default.
• W3011492883 hasConceptScore W3011492883C104317684 @default.
• W3011492883 hasConceptScore W3011492883C126322002 @default.
• W3011492883 hasConceptScore W3011492883C127561419 @default.
• W3011492883 hasConceptScore W3011492883C142724271 @default.
• W3011492883 hasConceptScore W3011492883C145059251 @default.
• W3011492883 hasConceptScore W3011492883C164705383 @default.
• W3011492883 hasConceptScore W3011492883C202751555 @default.
• W3011492883 hasConceptScore W3011492883C2776914184 @default.
• W3011492883 hasConceptScore W3011492883C2776992346 @default.
• W3011492883 hasConceptScore W3011492883C2777350992 @default.
• W3011492883 hasConceptScore W3011492883C2777411675 @default.
• W3011492883 hasConceptScore W3011492883C2781197716 @default.
• W3011492883 hasConceptScore W3011492883C500558357 @default.
• W3011492883 hasConceptScore W3011492883C55493867 @default.
• W3011492883 hasConceptScore W3011492883C58471807 @default.
• W3011492883 hasConceptScore W3011492883C71924100 @default.
• W3011492883 hasConceptScore W3011492883C86803240 @default.
• W3011492883 hasIssue "1" @default.
• W3011492883 hasLocation W30114928831 @default.
• W3011492883 hasLocation W30114928832 @default.
• W3011492883 hasLocation W30114928833 @default.
• W3011492883 hasLocation W30114928834 @default.
• W3011492883 hasOpenAccess W3011492883 @default.
• W3011492883 hasPrimaryLocation W30114928831 @default.
• W3011492883 hasRelatedWork W2067757913 @default.

• next