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- W3011494799 abstract "Xerostomia is defined as dry mouth due to reduced salivary flow. As a result of this, patients may have decreased efficiency in chewing and swallowing and an increased risk of dental disease, such as dental caries (i.e., dental decay). Xerostomia may be caused by medications, chronic disease, and radiotherapy. The prevalence of xerostomia in patients taking medications is higher than in those not taking medications (28% versus 7.5%, respectively). In particular, xerostomia is a potential side effect of psychoactive medications including antidepressants and antipsychotics. For example, patients taking tricyclic antidepressants had a 58% reduction in salivary flow rate compared to patients not taking tricyclic antidepressants, while those taking selective serotonin re-uptake inhibitors (SSRIs) had a 32% reduction compared to patients not taking SSRIs. Treatment for xerostomia includes but is not limited to mouth wash, artificial saliva, moisturizer, and cholinergic drugs (e.g., pilocarpine and cevimeline).Dry eyes is a condition in which the tears are inadequate to lubricate the eyes, which may lead to symptoms such as scratching, stinging or burning sensation, light sensitivity, and blurred vision. In 2019, it was estimated that 21.3% of Canadian adults may have dry eye disease (DED), which includes medication-induced dry eyes. Oral psychoactive medications can also contribute to dry eye disease. Treatment for dry eyes depends on the cause of the condition and includes punctal plugs for the tear draining ducts, anti-inflammatory drugs, artificial tears, and cholinergic drugs (e.g., pilocarpine and cevimeline).The purpose of this report is to examine recent literature regarding clinical effectiveness, cost-effectiveness and evidence-based guidelines of pilocarpine for the treatment of psychoactive medication-induced dry mouth or dry eyes." @default.
- W3011494799 created "2020-03-23" @default.
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- W3011494799 date "2019-12-11" @default.
- W3011494799 modified "2023-09-23" @default.
- W3011494799 title "Pilocarpine for Medication-induced Dry Mouth and Dry Eyes: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines [Internet]" @default.
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