Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011497613> ?p ?o ?g. }
- W3011497613 abstract "Abstract Bone morphogenetic protein (BMP)-2 plays a central role in bone-tissue engineering because of its potent bone-induction ability. However, the process of BMP-induced bone formation in vivo remains poorly elucidated. Here, we aimed to establish a method for intravital imaging of the entire process of BMP-2-induced ectopic bone formation. Using multicolor intravital imaging in transgenic mice, we visualized the spatiotemporal process of bone induction, including appearance and motility of osteoblasts and osteoclasts, angiogenesis, collagen-fiber formation, and bone-mineral deposition. Furthermore, we investigated how PTH1-34 affects BMP-2-induced bone formation, which revealed that PTH1-34 administration accelerated differentiation and increased the motility of osteoblasts, whereas it decreased morphological changes in osteoclasts. This is the first report on visualization of the entire process of BMP-2-induced bone formation using intravital imaging techniques, which, we believe, will contribute to our understanding of ectopic bone formation and provide new parameters for evaluating bone-forming activity." @default.
- W3011497613 created "2020-03-23" @default.
- W3011497613 creator A5001042153 @default.
- W3011497613 creator A5001669387 @default.
- W3011497613 creator A5002727514 @default.
- W3011497613 creator A5003165201 @default.
- W3011497613 creator A5007909918 @default.
- W3011497613 creator A5011338978 @default.
- W3011497613 creator A5032131242 @default.
- W3011497613 creator A5033945620 @default.
- W3011497613 creator A5058118162 @default.
- W3011497613 creator A5058503316 @default.
- W3011497613 date "2020-03-16" @default.
- W3011497613 modified "2023-10-13" @default.
- W3011497613 title "In vivo dynamic analysis of BMP-2-induced ectopic bone formation" @default.
- W3011497613 cites W1650226623 @default.
- W3011497613 cites W1783354296 @default.
- W3011497613 cites W1963726851 @default.
- W3011497613 cites W1974550900 @default.
- W3011497613 cites W1978850555 @default.
- W3011497613 cites W1979411287 @default.
- W3011497613 cites W1980068389 @default.
- W3011497613 cites W1984665266 @default.
- W3011497613 cites W1985384684 @default.
- W3011497613 cites W1986960611 @default.
- W3011497613 cites W1988807967 @default.
- W3011497613 cites W1999672981 @default.
- W3011497613 cites W2000460174 @default.
- W3011497613 cites W2011571192 @default.
- W3011497613 cites W2019196925 @default.
- W3011497613 cites W2019319143 @default.
- W3011497613 cites W2029614230 @default.
- W3011497613 cites W2032459370 @default.
- W3011497613 cites W2038690518 @default.
- W3011497613 cites W2038827577 @default.
- W3011497613 cites W2042722349 @default.
- W3011497613 cites W2049232413 @default.
- W3011497613 cites W2051011991 @default.
- W3011497613 cites W2059935911 @default.
- W3011497613 cites W2063474343 @default.
- W3011497613 cites W2065308524 @default.
- W3011497613 cites W2067437525 @default.
- W3011497613 cites W2070454881 @default.
- W3011497613 cites W2076353254 @default.
- W3011497613 cites W2090915792 @default.
- W3011497613 cites W2093050601 @default.
- W3011497613 cites W2115516793 @default.
- W3011497613 cites W2127733654 @default.
- W3011497613 cites W2140893098 @default.
- W3011497613 cites W2143214738 @default.
- W3011497613 cites W2159389698 @default.
- W3011497613 cites W2202679409 @default.
- W3011497613 cites W2259352860 @default.
- W3011497613 cites W2333668994 @default.
- W3011497613 cites W2520763435 @default.
- W3011497613 cites W2557547543 @default.
- W3011497613 cites W2740621193 @default.
- W3011497613 cites W2784193998 @default.
- W3011497613 cites W2790724263 @default.
- W3011497613 cites W2805829144 @default.
- W3011497613 cites W2895326014 @default.
- W3011497613 doi "https://doi.org/10.1038/s41598-020-61825-2" @default.
- W3011497613 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7076033" @default.
- W3011497613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32179857" @default.
- W3011497613 hasPublicationYear "2020" @default.
- W3011497613 type Work @default.
- W3011497613 sameAs 3011497613 @default.
- W3011497613 citedByCount "33" @default.
- W3011497613 countsByYear W30114976132020 @default.
- W3011497613 countsByYear W30114976132021 @default.
- W3011497613 countsByYear W30114976132022 @default.
- W3011497613 countsByYear W30114976132023 @default.
- W3011497613 crossrefType "journal-article" @default.
- W3011497613 hasAuthorship W3011497613A5001042153 @default.
- W3011497613 hasAuthorship W3011497613A5001669387 @default.
- W3011497613 hasAuthorship W3011497613A5002727514 @default.
- W3011497613 hasAuthorship W3011497613A5003165201 @default.
- W3011497613 hasAuthorship W3011497613A5007909918 @default.
- W3011497613 hasAuthorship W3011497613A5011338978 @default.
- W3011497613 hasAuthorship W3011497613A5032131242 @default.
- W3011497613 hasAuthorship W3011497613A5033945620 @default.
- W3011497613 hasAuthorship W3011497613A5058118162 @default.
- W3011497613 hasAuthorship W3011497613A5058503316 @default.
- W3011497613 hasBestOaLocation W30114976131 @default.
- W3011497613 hasConcept C104317684 @default.
- W3011497613 hasConcept C105702510 @default.
- W3011497613 hasConcept C125349252 @default.
- W3011497613 hasConcept C134018914 @default.
- W3011497613 hasConcept C142724271 @default.
- W3011497613 hasConcept C144746171 @default.
- W3011497613 hasConcept C150903083 @default.
- W3011497613 hasConcept C185592680 @default.
- W3011497613 hasConcept C202751555 @default.
- W3011497613 hasConcept C207001950 @default.
- W3011497613 hasConcept C2778260815 @default.
- W3011497613 hasConcept C2780394083 @default.
- W3011497613 hasConcept C2993291840 @default.
- W3011497613 hasConcept C30352789 @default.
- W3011497613 hasConcept C31507581 @default.
- W3011497613 hasConcept C502942594 @default.