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- W3011501504 endingPage "1819" @default.
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- W3011501504 abstract "Recent years have seen an unprecedented level of innovation in allosteric drug discovery and development, with multiple drug candidates advancing into clinical studies. From early examples of allosteric drugs like GABAA receptor modulators (benzodiazepines) in the 1960s to more recent GPCR negative allosteric modulators of CCR5 (maraviroc) approved in 2007, the opportunities for interrogating allosteric sites in drug discovery have expanded to other target classes such as protein–protein interactions, kinases, and nuclear hormone receptors. In this Innovation Letter, the authors highlight the latest advances of allosteric drug discovery from different target classes and novel emerging chemical modalities beyond small molecules." @default.
- W3011501504 created "2020-03-23" @default.
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- W3011501504 date "2020-03-10" @default.
- W3011501504 modified "2023-10-17" @default.
- W3011501504 title "Impact of Allosteric Modulation in Drug Discovery: Innovation in Emerging Chemical Modalities" @default.
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- W3011501504 doi "https://doi.org/10.1021/acsmedchemlett.9b00655" @default.
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