FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011514672> ?p ?o ?g. }

• W3011514672 endingPage "734" @default.
• W3011514672 startingPage "734" @default.
• W3011514672 abstract "Hypoxia-induced upregulation of lincRNA-p21 in tumor tissue was previously shown by our group to be related to poor prognosis in resected non-small cell lung cancer (NSCLC) patients. In the present study, we have evaluated the presence of lincRNA-p21 in extracellular vesicles (EVs) from NSCLC patients and assessed its potential as a prognostic biomarker. High EV lincRNA-p21 levels in blood from the tumor-draining vein were associated with shorter time to relapse and shorter overall survival. Moreover, the multivariate analysis identified high lincRNA-p21 levels as an independent prognostic marker. In addition, lincRNA-p21 was overexpressed in H23 and HCC44 NSCLC cell lines and their derived EVs under hypoxic conditions. Functional assays using human umbilical vein endothelial cells (HUVECs) showed that tumor-derived EVs enriched in lincRNA-p21 affected endothelial cells by promoting tube formation and enhancing tumor cell adhesion to endothelial cells. Additionally, the analysis of selected EV microRNAs related to angiogenesis and metastasis showed that the microRNAs correlated with EV lincRNA-p21 levels in both patients and cell lines. Finally, EV co-culture with HUVEC cells increased the expression of microRNAs and genes related to endothelial cell activation. In conclusion, EV lincRNA-p21 acts as a novel prognosis marker in resected NSCLC patients, promoting angiogenesis and metastasis." @default.
• W3011514672 created "2020-03-23" @default.
• W3011514672 creator A5023909202 @default.
• W3011514672 creator A5026970486 @default.
• W3011514672 creator A5033765620 @default.
• W3011514672 creator A5035019205 @default.
• W3011514672 creator A5044141782 @default.
• W3011514672 creator A5047020466 @default.
• W3011514672 creator A5071985935 @default.
• W3011514672 creator A5076845024 @default.
• W3011514672 creator A5083960636 @default.
• W3011514672 creator A5086247302 @default.
• W3011514672 creator A5091869476 @default.
• W3011514672 date "2020-03-20" @default.
• W3011514672 modified "2023-10-18" @default.
• W3011514672 title "Extracellular Vesicle lincRNA-p21 Expression in Tumor-Draining Pulmonary Vein Defines Prognosis in NSCLC and Modulates Endothelial Cell Behavior" @default.
• W3011514672 cites W1582095642 @default.
• W3011514672 cites W1883669539 @default.
• W3011514672 cites W1957438118 @default.
• W3011514672 cites W1974558929 @default.
• W3011514672 cites W1978967539 @default.
• W3011514672 cites W1980541833 @default.
• W3011514672 cites W1983794260 @default.
• W3011514672 cites W2001730700 @default.
• W3011514672 cites W2003748625 @default.
• W3011514672 cites W2015186671 @default.
• W3011514672 cites W2026209030 @default.
• W3011514672 cites W2037650640 @default.
• W3011514672 cites W2072506120 @default.
• W3011514672 cites W2081240902 @default.
• W3011514672 cites W2088942535 @default.
• W3011514672 cites W2098259366 @default.
• W3011514672 cites W2113876238 @default.
• W3011514672 cites W2126415088 @default.
• W3011514672 cites W2133650808 @default.
• W3011514672 cites W2146573461 @default.
• W3011514672 cites W2147900600 @default.
• W3011514672 cites W2148430424 @default.
• W3011514672 cites W2153169173 @default.
• W3011514672 cites W2153826038 @default.
• W3011514672 cites W2154395350 @default.
• W3011514672 cites W2155193116 @default.
• W3011514672 cites W2160333540 @default.
• W3011514672 cites W2161817637 @default.
• W3011514672 cites W2167959848 @default.
• W3011514672 cites W2211015870 @default.
• W3011514672 cites W2251552368 @default.
• W3011514672 cites W2374279538 @default.
• W3011514672 cites W2394902547 @default.
• W3011514672 cites W2398024913 @default.
• W3011514672 cites W2417698002 @default.
• W3011514672 cites W2423767910 @default.
• W3011514672 cites W2478316961 @default.
• W3011514672 cites W2556868315 @default.
• W3011514672 cites W2574514322 @default.
• W3011514672 cites W2608932173 @default.
• W3011514672 cites W2625214598 @default.
• W3011514672 cites W2625852738 @default.
• W3011514672 cites W2727358030 @default.
• W3011514672 cites W2738684096 @default.
• W3011514672 cites W2747512945 @default.
• W3011514672 cites W2778617734 @default.
• W3011514672 cites W2797185818 @default.
• W3011514672 cites W2807828500 @default.
• W3011514672 cites W2889646458 @default.
• W3011514672 cites W2889664504 @default.
• W3011514672 cites W2897897000 @default.
• W3011514672 cites W2898192510 @default.
• W3011514672 cites W2898342013 @default.
• W3011514672 cites W2900756811 @default.
• W3011514672 cites W2902415760 @default.
• W3011514672 cites W2904169994 @default.
• W3011514672 cites W2909077780 @default.
• W3011514672 cites W2918045954 @default.
• W3011514672 cites W2925276734 @default.
• W3011514672 cites W4207004940 @default.
• W3011514672 doi "https://doi.org/10.3390/cancers12030734" @default.
• W3011514672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7140053" @default.
• W3011514672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32244977" @default.
• W3011514672 hasPublicationYear "2020" @default.
• W3011514672 type Work @default.
• W3011514672 sameAs 3011514672 @default.
• W3011514672 citedByCount "32" @default.
• W3011514672 countsByYear W30115146722020 @default.
• W3011514672 countsByYear W30115146722021 @default.
• W3011514672 countsByYear W30115146722022 @default.
• W3011514672 countsByYear W30115146722023 @default.
• W3011514672 crossrefType "journal-article" @default.
• W3011514672 hasAuthorship W3011514672A5023909202 @default.
• W3011514672 hasAuthorship W3011514672A5026970486 @default.
• W3011514672 hasAuthorship W3011514672A5033765620 @default.
• W3011514672 hasAuthorship W3011514672A5035019205 @default.
• W3011514672 hasAuthorship W3011514672A5044141782 @default.
• W3011514672 hasAuthorship W3011514672A5047020466 @default.
• W3011514672 hasAuthorship W3011514672A5071985935 @default.
• W3011514672 hasAuthorship W3011514672A5076845024 @default.
• W3011514672 hasAuthorship W3011514672A5083960636 @default.
• W3011514672 hasAuthorship W3011514672A5086247302 @default.

• next