Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011515897> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W3011515897 abstract "Purpose To compare cardiac doses of different whole-breast optimization schemes including free-breathing (FB) tangential radiotherapy (TRT), deep-inspiration breath-hold (DIBH) TRT, and FB helical tomotherapy (HT). Methods Early-stage left-sided breast cancer patients who underwent breast-conserving surgery followed by adjuvant radiotherapy were included in the study. Planning images included FB and DIBH CT scans acquired in the same supine treatment position with both arms abducted. A hypofractionated regimen of 42.5 Gy in 16 fractions was used. Clinical target volume delineation was aided through the use of a radio-opaque wire. A 7-mm margin was used in generating the planning target volumes. TRT plans were generated both in FB and DIBH. For the FB tomotherapy technique, a first plan (Tomo 1) was optimized limiting the maximum contralateral breast dose to 3.1 Gy. A second tomotherapy plan (Tomo 2) focused on the reduction of the mean heart dose without controlling the contralateral breast dose. All plans were optimized to obtain an equivalent planning target volume (PTV) coverage of ≥95% of the prescribed dose while minimizing the dose to organs at risk. Results Twenty-three patients treated between October 2012 and March 2016 were included in this retrospective study. Eleven patients (48%) had at least one major cardiovascular risk factors including one patient (4%) with a history of myocardial infarction. Six patients (26%) had been exposed to cardiotoxic chemotherapy agents. The average mean dose to the heart was 3.1 Gy with FB TRT, 1.1 with DIBH TRT, 2.4 Gy for Tomo 1, and 1.5 Gy for Tomo 2. The mean dose to the left anterior descending artery was 27.0 Gy, 8.0 Gy, 13.7 Gy and 6.6 Gy for FB TRT, DIBH TRT, Tomo 1 and Tomo 2 plans respectively. Conclusion Different cardiac-sparing optimization schemes are possible when treating left breast cancer. Although DIBH offers clear mean heart dose reductions, tomotherapy can be an interesting alternative treatment modality to spare the heart and coronary vessels, notably in patients who cannot comply with DIBH." @default.
- W3011515897 created "2020-03-23" @default.
- W3011515897 creator A5004435450 @default.
- W3011515897 creator A5012430846 @default.
- W3011515897 creator A5017429853 @default.
- W3011515897 creator A5018656975 @default.
- W3011515897 creator A5029517342 @default.
- W3011515897 creator A5046035488 @default.
- W3011515897 creator A5053463008 @default.
- W3011515897 creator A5057484084 @default.
- W3011515897 creator A5070400281 @default.
- W3011515897 date "2020-03-12" @default.
- W3011515897 modified "2023-09-25" @default.
- W3011515897 title "Cardiac Sparing with Personalized Treatment Planning for Early-stage Left Breast Cancer" @default.
- W3011515897 cites W1543915570 @default.
- W3011515897 cites W1974175112 @default.
- W3011515897 cites W1987536026 @default.
- W3011515897 cites W2055662013 @default.
- W3011515897 cites W2083928251 @default.
- W3011515897 cites W2090785772 @default.
- W3011515897 cites W2098560759 @default.
- W3011515897 cites W2100025800 @default.
- W3011515897 cites W2126390899 @default.
- W3011515897 cites W2154375587 @default.
- W3011515897 cites W2497980793 @default.
- W3011515897 cites W2519353639 @default.
- W3011515897 cites W2560560709 @default.
- W3011515897 cites W2793033306 @default.
- W3011515897 doi "https://doi.org/10.7759/cureus.7247" @default.
- W3011515897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7152579" @default.
- W3011515897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32292662" @default.
- W3011515897 hasPublicationYear "2020" @default.
- W3011515897 type Work @default.
- W3011515897 sameAs 3011515897 @default.
- W3011515897 citedByCount "7" @default.
- W3011515897 countsByYear W30115158972021 @default.
- W3011515897 countsByYear W30115158972022 @default.
- W3011515897 countsByYear W30115158972023 @default.
- W3011515897 crossrefType "journal-article" @default.
- W3011515897 hasAuthorship W3011515897A5004435450 @default.
- W3011515897 hasAuthorship W3011515897A5012430846 @default.
- W3011515897 hasAuthorship W3011515897A5017429853 @default.
- W3011515897 hasAuthorship W3011515897A5018656975 @default.
- W3011515897 hasAuthorship W3011515897A5029517342 @default.
- W3011515897 hasAuthorship W3011515897A5046035488 @default.
- W3011515897 hasAuthorship W3011515897A5053463008 @default.
- W3011515897 hasAuthorship W3011515897A5057484084 @default.
- W3011515897 hasAuthorship W3011515897A5070400281 @default.
- W3011515897 hasBestOaLocation W30115158971 @default.
- W3011515897 hasConcept C121608353 @default.
- W3011515897 hasConcept C125567185 @default.
- W3011515897 hasConcept C126322002 @default.
- W3011515897 hasConcept C126838900 @default.
- W3011515897 hasConcept C141071460 @default.
- W3011515897 hasConcept C146357865 @default.
- W3011515897 hasConcept C151730666 @default.
- W3011515897 hasConcept C201645570 @default.
- W3011515897 hasConcept C2776713427 @default.
- W3011515897 hasConcept C2908623805 @default.
- W3011515897 hasConcept C2989005 @default.
- W3011515897 hasConcept C509974204 @default.
- W3011515897 hasConcept C530470458 @default.
- W3011515897 hasConcept C71924100 @default.
- W3011515897 hasConcept C86803240 @default.
- W3011515897 hasConceptScore W3011515897C121608353 @default.
- W3011515897 hasConceptScore W3011515897C125567185 @default.
- W3011515897 hasConceptScore W3011515897C126322002 @default.
- W3011515897 hasConceptScore W3011515897C126838900 @default.
- W3011515897 hasConceptScore W3011515897C141071460 @default.
- W3011515897 hasConceptScore W3011515897C146357865 @default.
- W3011515897 hasConceptScore W3011515897C151730666 @default.
- W3011515897 hasConceptScore W3011515897C201645570 @default.
- W3011515897 hasConceptScore W3011515897C2776713427 @default.
- W3011515897 hasConceptScore W3011515897C2908623805 @default.
- W3011515897 hasConceptScore W3011515897C2989005 @default.
- W3011515897 hasConceptScore W3011515897C509974204 @default.
- W3011515897 hasConceptScore W3011515897C530470458 @default.
- W3011515897 hasConceptScore W3011515897C71924100 @default.
- W3011515897 hasConceptScore W3011515897C86803240 @default.
- W3011515897 hasLocation W30115158971 @default.
- W3011515897 hasLocation W30115158972 @default.
- W3011515897 hasLocation W30115158973 @default.
- W3011515897 hasLocation W30115158974 @default.
- W3011515897 hasOpenAccess W3011515897 @default.
- W3011515897 hasPrimaryLocation W30115158971 @default.
- W3011515897 hasRelatedWork W1973593031 @default.
- W3011515897 hasRelatedWork W2054476649 @default.
- W3011515897 hasRelatedWork W2056302729 @default.
- W3011515897 hasRelatedWork W2069431437 @default.
- W3011515897 hasRelatedWork W2069509937 @default.
- W3011515897 hasRelatedWork W2072122564 @default.
- W3011515897 hasRelatedWork W2518678316 @default.
- W3011515897 hasRelatedWork W4307836388 @default.
- W3011515897 hasRelatedWork W984630715 @default.
- W3011515897 hasRelatedWork W1981938658 @default.
- W3011515897 isParatext "false" @default.
- W3011515897 isRetracted "false" @default.
- W3011515897 magId "3011515897" @default.
- W3011515897 workType "article" @default.