Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011522042> ?p ?o ?g. }
- W3011522042 endingPage "697" @default.
- W3011522042 startingPage "685" @default.
- W3011522042 abstract "Abstract Epitopes derived from mutated cancer proteins elicit strong antitumor T-cell responses that correlate with clinical efficacy in a proportion of patients. However, it remains unclear whether the subcellular localization of mutated proteins influences the efficiency of T-cell priming. To address this question, we compared the immunogenicity of NY-ESO-1 and OVA localized either in the cytosol or in mitochondria. We showed that tumors expressing mitochondrial-localized NY-ESO-1 and OVA proteins elicit significantdly higher frequencies of antigen-specific CD8+ T cells in vivo. We also demonstrated that this stronger immune response is dependent on the mitochondrial location of the antigenic proteins, which contributes to their higher steady-state amount, compared with cytosolic localized proteins. Consistent with these findings, we showed that injection of mitochondria purified from B16 melanoma cells can protect mice from a challenge with B16 cells, but not with irrelevant tumors. Finally, we extended these findings to cancer patients by demonstrating the presence of T-cell responses specific for mutated mitochondrial-localized proteins. These findings highlight the utility of prioritizing epitopes derived from mitochondrial-localized mutated proteins as targets for cancer vaccination strategies." @default.
- W3011522042 created "2020-03-23" @default.
- W3011522042 creator A5000565081 @default.
- W3011522042 creator A5001016649 @default.
- W3011522042 creator A5001602095 @default.
- W3011522042 creator A5006676892 @default.
- W3011522042 creator A5007124414 @default.
- W3011522042 creator A5008918795 @default.
- W3011522042 creator A5010390926 @default.
- W3011522042 creator A5031476885 @default.
- W3011522042 creator A5046677644 @default.
- W3011522042 creator A5054265552 @default.
- W3011522042 creator A5056805446 @default.
- W3011522042 creator A5058514738 @default.
- W3011522042 creator A5060388462 @default.
- W3011522042 creator A5071456499 @default.
- W3011522042 creator A5071595533 @default.
- W3011522042 creator A5077065834 @default.
- W3011522042 creator A5078937992 @default.
- W3011522042 date "2020-05-01" @default.
- W3011522042 modified "2023-10-16" @default.
- W3011522042 title "Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells" @default.
- W3011522042 cites W1545441058 @default.
- W3011522042 cites W1548280824 @default.
- W3011522042 cites W1988869609 @default.
- W3011522042 cites W1993238707 @default.
- W3011522042 cites W1994826332 @default.
- W3011522042 cites W2001656273 @default.
- W3011522042 cites W2005591012 @default.
- W3011522042 cites W2011458181 @default.
- W3011522042 cites W2012137725 @default.
- W3011522042 cites W2017804304 @default.
- W3011522042 cites W2018088338 @default.
- W3011522042 cites W2022293786 @default.
- W3011522042 cites W2046505430 @default.
- W3011522042 cites W2063611032 @default.
- W3011522042 cites W2067267037 @default.
- W3011522042 cites W2068853695 @default.
- W3011522042 cites W2081746044 @default.
- W3011522042 cites W2084482466 @default.
- W3011522042 cites W2092157690 @default.
- W3011522042 cites W2093168274 @default.
- W3011522042 cites W2102164310 @default.
- W3011522042 cites W2106089096 @default.
- W3011522042 cites W2116156361 @default.
- W3011522042 cites W2116487491 @default.
- W3011522042 cites W2132413371 @default.
- W3011522042 cites W2134306338 @default.
- W3011522042 cites W2136883776 @default.
- W3011522042 cites W2138601221 @default.
- W3011522042 cites W2143655005 @default.
- W3011522042 cites W2148220764 @default.
- W3011522042 cites W2161901483 @default.
- W3011522042 cites W2296807971 @default.
- W3011522042 cites W2339331299 @default.
- W3011522042 cites W2404396229 @default.
- W3011522042 cites W2461271870 @default.
- W3011522042 cites W2469928790 @default.
- W3011522042 cites W2525836450 @default.
- W3011522042 cites W2604971674 @default.
- W3011522042 cites W2605808699 @default.
- W3011522042 cites W2744546677 @default.
- W3011522042 cites W2755102409 @default.
- W3011522042 cites W2767699537 @default.
- W3011522042 cites W2767891987 @default.
- W3011522042 cites W2779221466 @default.
- W3011522042 cites W2793542493 @default.
- W3011522042 cites W2794478976 @default.
- W3011522042 cites W2802455484 @default.
- W3011522042 cites W2911441123 @default.
- W3011522042 cites W4236294751 @default.
- W3011522042 doi "https://doi.org/10.1158/2326-6066.cir-19-0467" @default.
- W3011522042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32205315" @default.
- W3011522042 hasPublicationYear "2020" @default.
- W3011522042 type Work @default.
- W3011522042 sameAs 3011522042 @default.
- W3011522042 citedByCount "4" @default.
- W3011522042 countsByYear W30115220422021 @default.
- W3011522042 countsByYear W30115220422022 @default.
- W3011522042 crossrefType "journal-article" @default.
- W3011522042 hasAuthorship W3011522042A5000565081 @default.
- W3011522042 hasAuthorship W3011522042A5001016649 @default.
- W3011522042 hasAuthorship W3011522042A5001602095 @default.
- W3011522042 hasAuthorship W3011522042A5006676892 @default.
- W3011522042 hasAuthorship W3011522042A5007124414 @default.
- W3011522042 hasAuthorship W3011522042A5008918795 @default.
- W3011522042 hasAuthorship W3011522042A5010390926 @default.
- W3011522042 hasAuthorship W3011522042A5031476885 @default.
- W3011522042 hasAuthorship W3011522042A5046677644 @default.
- W3011522042 hasAuthorship W3011522042A5054265552 @default.
- W3011522042 hasAuthorship W3011522042A5056805446 @default.
- W3011522042 hasAuthorship W3011522042A5058514738 @default.
- W3011522042 hasAuthorship W3011522042A5060388462 @default.
- W3011522042 hasAuthorship W3011522042A5071456499 @default.
- W3011522042 hasAuthorship W3011522042A5071595533 @default.
- W3011522042 hasAuthorship W3011522042A5077065834 @default.
- W3011522042 hasAuthorship W3011522042A5078937992 @default.
- W3011522042 hasBestOaLocation W30115220421 @default.