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- W3011589746 endingPage "331" @default.
- W3011589746 startingPage "310" @default.
- W3011589746 abstract "Grainyhead-like 2 (GRHL2), one of the three homologs of Drosophila grainyhead, contributes to epithelial morphogenesis and differentiation. Dysregulation of GRHL2 has been shown to be involved in hearing loss and neural tube defects during embryogenesis. Moreover, it is well-recognized that GRHL2 suppresses epithelial-to-mesenchymal transition (EMT) that is required for migration and invasion of carcinoma, implicating, GRHL2 in carcinogenesis. Diverse mechanisms, as well as the varied roles of GRHL2 in different tumor tissues, have been elucidated. However, the functions of GRHL2 appear to be more complicated than initially thought. GRHL2, acting as either a tumor enhancer or a tumor inhibitor, depends on the type of cancer. In this review, we summarize research progress about normal physiological functions of GRHL2 including epithelial morphogenesis, neural tube closure, and hearing loss. Moreover, the mechanisms of GRHL2 in tumorigenesis, containing EMT suppression, forming a negative feedback loop with ZEB1 and miR200 family, interactions with estrogen receptor (ER)-dependent signaling pathway, regulation of telomerase reverse transcriptase and relationships with TGF-beta signaling pathway are discussed in this review in an effort to better understand the roles of GRHL2 in a variety of cancers toward the goal of GRHL2-targeted treatment in the near future." @default.
- W3011589746 created "2020-03-23" @default.
- W3011589746 creator A5025330252 @default.
- W3011589746 creator A5036688974 @default.
- W3011589746 creator A5039869995 @default.
- W3011589746 creator A5040287148 @default.
- W3011589746 creator A5060838215 @default.
- W3011589746 creator A5083932487 @default.
- W3011589746 date "2020-01-01" @default.
- W3011589746 modified "2023-10-12" @default.
- W3011589746 title "Grainyhead-like 2 as a double-edged sword in development and cancer." @default.
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