Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011598546> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3011598546 abstract "6055 Background: Strong evidence supports the hypothesis that high-risk human papillomavirus (HPV), particularly HPV16, is a causative agent for an increasing subset of oropharyngeal squamous cell carcinomas (OPSCC). These tumors have distinct oncogenic mechanisms and a more favorable prognosis than tobacco induced OPSCC. Although these differences emphasize the need for a specific therapeutic approach, HPV status is still not used to guide treatment. A better understanding of the molecular profile related to HPV16 induced OPSCC may help to develop personalized treatments. Methods: To identify an HPV16-related molecular signature, we compared the gene expression profile of 15 transcriptionally active HPV16-positive and 15 HPV16-negative OPSCC. The study was conducted in two steps. First, a learning set of 16 OPSCC comprising 8 HPV16-positives and 8 HPV16-negatives OPSCC was analyzed in order to identify the signature. Potentially confounding factors of stage, sex and tobacco consumption were equally distributed in both groups. Secondarily, the robustness of this signature was further confirmed by blind case-by-case classification of an independent set of 14 OPSCC. Results: We identified a signature composed of 224 genes which discriminates HPV16-induced OPSCC from their tobacco induced counterparts. After the viral status was revealed, 13 out of 14 tumors were correctly classified according to tumor etiology, 1/14 was undetermined and none were misclassified. Interestingly, deregulated genes in HPV16-positive tumors are principally involved in innate immunity, in cell cycle regulation through the TP53/RB/E2F pathway, and autophagy through mTOR regulation. Well known targets of E6 and E7 proteins are also found to be deregulated. Conclusions: Our results demonstrate that a set of selected genes can distinguish OPSCC according to etiology. These genes shed light on HPV16 induced carcinogenesis since specific molecular pathways are deregulated. Further investigations are required for a better understanding of the differing natural histories and biological properties of these tumors. These properties may be exploited as a target of novel therapeutic agents in HPV-related OPSCC." @default.
- W3011598546 created "2020-03-23" @default.
- W3011598546 creator A5004410076 @default.
- W3011598546 creator A5008235770 @default.
- W3011598546 creator A5013969112 @default.
- W3011598546 creator A5016000699 @default.
- W3011598546 creator A5061713431 @default.
- W3011598546 creator A5078175555 @default.
- W3011598546 creator A5084661761 @default.
- W3011598546 creator A5085842128 @default.
- W3011598546 date "2013-05-20" @default.
- W3011598546 modified "2023-09-26" @default.
- W3011598546 title "Use of gene expression signature to discriminate oropharyngeal cancers according to HPV16 status." @default.
- W3011598546 doi "https://doi.org/10.1200/jco.2013.31.15_suppl.6055" @default.
- W3011598546 hasPublicationYear "2013" @default.
- W3011598546 type Work @default.
- W3011598546 sameAs 3011598546 @default.
- W3011598546 citedByCount "0" @default.
- W3011598546 crossrefType "journal-article" @default.
- W3011598546 hasAuthorship W3011598546A5004410076 @default.
- W3011598546 hasAuthorship W3011598546A5008235770 @default.
- W3011598546 hasAuthorship W3011598546A5013969112 @default.
- W3011598546 hasAuthorship W3011598546A5016000699 @default.
- W3011598546 hasAuthorship W3011598546A5061713431 @default.
- W3011598546 hasAuthorship W3011598546A5078175555 @default.
- W3011598546 hasAuthorship W3011598546A5084661761 @default.
- W3011598546 hasAuthorship W3011598546A5085842128 @default.
- W3011598546 hasConcept C104317684 @default.
- W3011598546 hasConcept C143998085 @default.
- W3011598546 hasConcept C150194340 @default.
- W3011598546 hasConcept C18431079 @default.
- W3011598546 hasConcept C2779733811 @default.
- W3011598546 hasConcept C502942594 @default.
- W3011598546 hasConcept C54355233 @default.
- W3011598546 hasConcept C71924100 @default.
- W3011598546 hasConcept C86803240 @default.
- W3011598546 hasConceptScore W3011598546C104317684 @default.
- W3011598546 hasConceptScore W3011598546C143998085 @default.
- W3011598546 hasConceptScore W3011598546C150194340 @default.
- W3011598546 hasConceptScore W3011598546C18431079 @default.
- W3011598546 hasConceptScore W3011598546C2779733811 @default.
- W3011598546 hasConceptScore W3011598546C502942594 @default.
- W3011598546 hasConceptScore W3011598546C54355233 @default.
- W3011598546 hasConceptScore W3011598546C71924100 @default.
- W3011598546 hasConceptScore W3011598546C86803240 @default.
- W3011598546 hasLocation W30115985461 @default.
- W3011598546 hasOpenAccess W3011598546 @default.
- W3011598546 hasPrimaryLocation W30115985461 @default.
- W3011598546 hasRelatedWork W1832356772 @default.
- W3011598546 hasRelatedWork W1999308381 @default.
- W3011598546 hasRelatedWork W2003171254 @default.
- W3011598546 hasRelatedWork W2100775423 @default.
- W3011598546 hasRelatedWork W2161202863 @default.
- W3011598546 hasRelatedWork W2254150779 @default.
- W3011598546 hasRelatedWork W2264701162 @default.
- W3011598546 hasRelatedWork W2291902708 @default.
- W3011598546 hasRelatedWork W2477974089 @default.
- W3011598546 hasRelatedWork W2494184365 @default.
- W3011598546 hasRelatedWork W2582225554 @default.
- W3011598546 hasRelatedWork W2615745557 @default.
- W3011598546 hasRelatedWork W2773952648 @default.
- W3011598546 hasRelatedWork W2806781666 @default.
- W3011598546 hasRelatedWork W2889494305 @default.
- W3011598546 hasRelatedWork W2907420784 @default.
- W3011598546 hasRelatedWork W2913804658 @default.
- W3011598546 hasRelatedWork W3004553637 @default.
- W3011598546 hasRelatedWork W3008984359 @default.
- W3011598546 hasRelatedWork W3012888270 @default.
- W3011598546 isParatext "false" @default.
- W3011598546 isRetracted "false" @default.
- W3011598546 magId "3011598546" @default.
- W3011598546 workType "article" @default.