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- W3011638844 endingPage "165767" @default.
- W3011638844 startingPage "165767" @default.
- W3011638844 abstract "Poor diet and obesity are associated with cognitive impairment throughout adulthood, and increased dementia risk in aging. Here we review the current literature interrogating the mechanisms by which diets high in fat, or fat and sugar lead to cognitive impairment, focusing on changes to gut microbiome composition, inflammatory signalling and blood-brain barrier integrity. Preclinical studies indicate weight gain is not necessary for diet-induced cognitive impairment. Rather, gut microbiome composition, and systemic and central inflammatory processes appear to contribute to diet-induced cognitive impairment. While both obese humans and rodents exhibit reduced blood-brain barrier integrity, cognitive impairments precede these changes, suggesting other mechanisms may underly diet-induced cognitive changes. Other potential candidates include hormone, glucoregulatory and cardiovascular changes. Poor diet and obesity act through multiple mechanisms to affect cognitive health and the challenge for future research is to identify key processes that can be reversed to improve cognition and quality of life." @default.
- W3011638844 created "2020-03-23" @default.
- W3011638844 creator A5030791967 @default.
- W3011638844 creator A5045868347 @default.
- W3011638844 date "2020-06-01" @default.
- W3011638844 modified "2023-10-03" @default.
- W3011638844 title "Diet, inflammation and the gut microbiome: Mechanisms for obesity-associated cognitive impairment" @default.
- W3011638844 cites W1196450161 @default.
- W3011638844 cites W1515023627 @default.
- W3011638844 cites W1530365712 @default.
- W3011638844 cites W1534168873 @default.
- W3011638844 cites W1555708061 @default.
- W3011638844 cites W1620873765 @default.
- W3011638844 cites W1933841656 @default.
- W3011638844 cites W1954468852 @default.
- W3011638844 cites W1966770755 @default.
- W3011638844 cites W1971415551 @default.
- W3011638844 cites W1974696451 @default.
- W3011638844 cites W1981514736 @default.
- W3011638844 cites W1983000029 @default.
- W3011638844 cites W1983189694 @default.
- W3011638844 cites W1987478242 @default.
- W3011638844 cites W1988774935 @default.
- W3011638844 cites W1994249730 @default.
- W3011638844 cites W1997493159 @default.
- W3011638844 cites W2000777408 @default.
- W3011638844 cites W2004549986 @default.
- W3011638844 cites W2005288083 @default.
- W3011638844 cites W2010055058 @default.
- W3011638844 cites W2011121242 @default.
- W3011638844 cites W2011954431 @default.
- W3011638844 cites W2019250366 @default.
- W3011638844 cites W2024590659 @default.
- W3011638844 cites W2035885128 @default.
- W3011638844 cites W2037420920 @default.
- W3011638844 cites W2038213717 @default.
- W3011638844 cites W2043823279 @default.
- W3011638844 cites W2044729604 @default.
- W3011638844 cites W2046910746 @default.
- W3011638844 cites W2049616256 @default.
- W3011638844 cites W2055264753 @default.
- W3011638844 cites W2060185417 @default.
- W3011638844 cites W2060997320 @default.
- W3011638844 cites W2069296495 @default.
- W3011638844 cites W2069968910 @default.
- W3011638844 cites W2070381267 @default.
- W3011638844 cites W2073332363 @default.
- W3011638844 cites W2078378773 @default.
- W3011638844 cites W2079040703 @default.
- W3011638844 cites W2083501377 @default.
- W3011638844 cites W2087084954 @default.
- W3011638844 cites W2090309711 @default.
- W3011638844 cites W2090409064 @default.
- W3011638844 cites W2094448862 @default.
- W3011638844 cites W2098275471 @default.
- W3011638844 cites W2102696708 @default.
- W3011638844 cites W2108880048 @default.
- W3011638844 cites W2109113634 @default.
- W3011638844 cites W2109392327 @default.
- W3011638844 cites W2112694389 @default.
- W3011638844 cites W2114346250 @default.
- W3011638844 cites W2117029190 @default.
- W3011638844 cites W2117807651 @default.
- W3011638844 cites W2121076832 @default.
- W3011638844 cites W2131536322 @default.
- W3011638844 cites W2134041954 @default.
- W3011638844 cites W2135231776 @default.
- W3011638844 cites W2155704304 @default.
- W3011638844 cites W2157103967 @default.
- W3011638844 cites W2161332823 @default.
- W3011638844 cites W2166562121 @default.
- W3011638844 cites W2166927814 @default.
- W3011638844 cites W2191806457 @default.
- W3011638844 cites W2199659062 @default.
- W3011638844 cites W2206695638 @default.
- W3011638844 cites W2221828447 @default.
- W3011638844 cites W2253322525 @default.
- W3011638844 cites W2277411172 @default.
- W3011638844 cites W2296915958 @default.
- W3011638844 cites W2299228567 @default.
- W3011638844 cites W2301970460 @default.
- W3011638844 cites W2343236926 @default.
- W3011638844 cites W2443485586 @default.
- W3011638844 cites W2476432163 @default.
- W3011638844 cites W2482754741 @default.
- W3011638844 cites W2505127413 @default.
- W3011638844 cites W2510681644 @default.
- W3011638844 cites W2528793084 @default.
- W3011638844 cites W2550589597 @default.
- W3011638844 cites W2557198675 @default.
- W3011638844 cites W2559949553 @default.
- W3011638844 cites W2565999923 @default.
- W3011638844 cites W2577163439 @default.
- W3011638844 cites W2591566720 @default.
- W3011638844 cites W2592770138 @default.
- W3011638844 cites W2605949832 @default.
- W3011638844 cites W2606557183 @default.
- W3011638844 cites W2613930978 @default.