Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011645656> ?p ?o ?g. }
- W3011645656 abstract "Sleep deprivation (SD) induces hippocampal damage. Hydrogen sulfide (H2S) is a neuronal protective factor. Silence information regulating factor 1 (Sirt1) plays an important role in neuroprotection. Therefore, this study was aimed at exploring whether H2S meliorates SD-induced hippocampal damage and whether Sirt1 mediates this protective role of H2S. We found that sodium hydrosulfide (NaHS, a donor of H2S) alleviated SD-generated hippocampal oxidative stress, including increases in the activation of SOD and the level of GSH as well as a decrease in the level of MDA. Meanwhile, we found that NaHS reduced SD-exerted hippocampal endoplasmic reticulum (ER) Stress, including downregulations of GRP78, CHOP, and cleaved-caspase-12 expression. Moreover, NaHS reduced the apoptosis in the SD-exposed hippocampus, and this included decreases in the number of apoptotic cells and the activation of caspase-3, downregulation of Bax expression, and upregulation of Bcl-2 expression. NaHS upregulated the expression of Sirt1 in the hippocampus of SD-exposed rats. Furthermore, Sirtinol, the inhibitor of Sirt1, abrogated the protection of NaHS against SD-exerted hippocampal oxidative stress, ER stress, and apoptosis. These results suggested that H2S alleviates SD-induced hippocampal damage by upregulation of hippocampal Sirt1." @default.
- W3011645656 created "2020-03-23" @default.
- W3011645656 creator A5002233203 @default.
- W3011645656 creator A5002711155 @default.
- W3011645656 creator A5007095215 @default.
- W3011645656 creator A5035532245 @default.
- W3011645656 creator A5037717340 @default.
- W3011645656 creator A5044321008 @default.
- W3011645656 creator A5044675035 @default.
- W3011645656 creator A5064189236 @default.
- W3011645656 creator A5083507260 @default.
- W3011645656 creator A5088695928 @default.
- W3011645656 date "2020-03-11" @default.
- W3011645656 modified "2023-10-01" @default.
- W3011645656 title "Hydrogen Sulfide Prevents Sleep Deprivation-Induced Hippocampal Damage by Upregulation of Sirt1 in the Hippocampus" @default.
- W3011645656 cites W1508727168 @default.
- W3011645656 cites W1554223333 @default.
- W3011645656 cites W1560090495 @default.
- W3011645656 cites W1583309920 @default.
- W3011645656 cites W1590346268 @default.
- W3011645656 cites W1863554980 @default.
- W3011645656 cites W1974980148 @default.
- W3011645656 cites W1976599798 @default.
- W3011645656 cites W1980917913 @default.
- W3011645656 cites W1981338699 @default.
- W3011645656 cites W1984917111 @default.
- W3011645656 cites W1996849473 @default.
- W3011645656 cites W1997311794 @default.
- W3011645656 cites W1999845971 @default.
- W3011645656 cites W2017525855 @default.
- W3011645656 cites W2019044369 @default.
- W3011645656 cites W2035140127 @default.
- W3011645656 cites W2039209034 @default.
- W3011645656 cites W2039840443 @default.
- W3011645656 cites W2053670265 @default.
- W3011645656 cites W2061600758 @default.
- W3011645656 cites W2067091953 @default.
- W3011645656 cites W2067554187 @default.
- W3011645656 cites W2067599571 @default.
- W3011645656 cites W2071400945 @default.
- W3011645656 cites W2074740541 @default.
- W3011645656 cites W2074840874 @default.
- W3011645656 cites W2075043109 @default.
- W3011645656 cites W2078991822 @default.
- W3011645656 cites W2079613741 @default.
- W3011645656 cites W2085230857 @default.
- W3011645656 cites W2097948853 @default.
- W3011645656 cites W2127450768 @default.
- W3011645656 cites W2152390180 @default.
- W3011645656 cites W2152870184 @default.
- W3011645656 cites W2162695817 @default.
- W3011645656 cites W2166295870 @default.
- W3011645656 cites W2262929199 @default.
- W3011645656 cites W2442659062 @default.
- W3011645656 cites W2461453575 @default.
- W3011645656 cites W2490633794 @default.
- W3011645656 cites W2576327900 @default.
- W3011645656 cites W2584909754 @default.
- W3011645656 cites W2592564728 @default.
- W3011645656 cites W2611106583 @default.
- W3011645656 cites W2736942442 @default.
- W3011645656 cites W2752509335 @default.
- W3011645656 cites W2753641205 @default.
- W3011645656 cites W2765989727 @default.
- W3011645656 cites W2781773803 @default.
- W3011645656 cites W2794826644 @default.
- W3011645656 cites W2797020166 @default.
- W3011645656 cites W2803820885 @default.
- W3011645656 cites W2807109837 @default.
- W3011645656 cites W2810354805 @default.
- W3011645656 cites W2891700574 @default.
- W3011645656 cites W2896631236 @default.
- W3011645656 cites W4245299678 @default.
- W3011645656 doi "https://doi.org/10.3389/fnins.2020.00169" @default.
- W3011645656 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7078349" @default.
- W3011645656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32218719" @default.
- W3011645656 hasPublicationYear "2020" @default.
- W3011645656 type Work @default.
- W3011645656 sameAs 3011645656 @default.
- W3011645656 citedByCount "16" @default.
- W3011645656 countsByYear W30116456562020 @default.
- W3011645656 countsByYear W30116456562021 @default.
- W3011645656 countsByYear W30116456562022 @default.
- W3011645656 countsByYear W30116456562023 @default.
- W3011645656 crossrefType "journal-article" @default.
- W3011645656 hasAuthorship W3011645656A5002233203 @default.
- W3011645656 hasAuthorship W3011645656A5002711155 @default.
- W3011645656 hasAuthorship W3011645656A5007095215 @default.
- W3011645656 hasAuthorship W3011645656A5035532245 @default.
- W3011645656 hasAuthorship W3011645656A5037717340 @default.
- W3011645656 hasAuthorship W3011645656A5044321008 @default.
- W3011645656 hasAuthorship W3011645656A5044675035 @default.
- W3011645656 hasAuthorship W3011645656A5064189236 @default.
- W3011645656 hasAuthorship W3011645656A5083507260 @default.
- W3011645656 hasAuthorship W3011645656A5088695928 @default.
- W3011645656 hasBestOaLocation W30116456561 @default.
- W3011645656 hasConcept C104317684 @default.
- W3011645656 hasConcept C127561419 @default.
- W3011645656 hasConcept C134018914 @default.
- W3011645656 hasConcept C139447449 @default.