FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011657264> ?p ?o ?g. }

• W3011657264 endingPage "3204" @default.
• W3011657264 startingPage "3191" @default.
• W3011657264 abstract "The proteins MinD, MinE and MinC are constitutive for the spatiotemporal organization of cell division in Escherichia coli, in particular, for positioning the division machinery at mid-cell. To achieve this function, the ATPase MinD and the ATPase-activating protein MinE undergo coordinated pole-to-pole oscillations and have thus become a paradigm for protein pattern formation in biology. The exact molecular mechanisms enabling MinDE self-organization, and particularly the role of cooperativity in the membrane binding of MinD, thought to be a key requirement, have remained poorly understood. However, for bottom-up synthetic biology aiming at a de novo design of key cellular features, elucidating these mechanisms is of great relevance. By combining in vitro reconstitution with rationally guided mutagenesis of MinD, we found that when bound to membranes, MinD displays new interfaces for multimerization, which are distinct from the canonical MinD dimerization site. We propose that these additional transient interactions contribute to the local self-enhancement of MinD at the membrane, while their relative lability maintains the structural plasticity required for MinDE wave propagation. This could represent a powerful structural regulation feature not reported so far for self-organizing proteins." @default.
• W3011657264 created "2020-03-23" @default.
• W3011657264 creator A5005553582 @default.
• W3011657264 creator A5009609494 @default.
• W3011657264 creator A5025940446 @default.
• W3011657264 creator A5086296055 @default.
• W3011657264 date "2020-05-01" @default.
• W3011657264 modified "2023-09-27" @default.
• W3011657264 title "Local Self-Enhancement of MinD Membrane Binding in Min Protein Pattern Formation" @default.
• W3011657264 cites W1895202121 @default.
• W3011657264 cites W1907612139 @default.
• W3011657264 cites W1926568554 @default.
• W3011657264 cites W1943903427 @default.
• W3011657264 cites W1970904457 @default.
• W3011657264 cites W1975390541 @default.
• W3011657264 cites W2008228685 @default.
• W3011657264 cites W2008433064 @default.
• W3011657264 cites W2009415450 @default.
• W3011657264 cites W2010195422 @default.
• W3011657264 cites W2015094506 @default.
• W3011657264 cites W2016350172 @default.
• W3011657264 cites W2021213676 @default.
• W3011657264 cites W2027057433 @default.
• W3011657264 cites W2054729216 @default.
• W3011657264 cites W2055418934 @default.
• W3011657264 cites W2057251045 @default.
• W3011657264 cites W2077176951 @default.
• W3011657264 cites W2081395979 @default.
• W3011657264 cites W2083565918 @default.
• W3011657264 cites W2090312476 @default.
• W3011657264 cites W2093295626 @default.
• W3011657264 cites W2099904987 @default.
• W3011657264 cites W2100070946 @default.
• W3011657264 cites W2106246537 @default.
• W3011657264 cites W2107842051 @default.
• W3011657264 cites W2115701204 @default.
• W3011657264 cites W2127811731 @default.
• W3011657264 cites W2131252553 @default.
• W3011657264 cites W2153979160 @default.
• W3011657264 cites W2162247704 @default.
• W3011657264 cites W2167279371 @default.
• W3011657264 cites W2191824721 @default.
• W3011657264 cites W2531289496 @default.
• W3011657264 cites W2657598059 @default.
• W3011657264 cites W2773372416 @default.
• W3011657264 cites W2801140473 @default.
• W3011657264 cites W2808171107 @default.
• W3011657264 cites W2890151358 @default.
• W3011657264 cites W2906503826 @default.
• W3011657264 cites W2912781299 @default.
• W3011657264 cites W2959440892 @default.
• W3011657264 cites W2989906483 @default.
• W3011657264 doi "https://doi.org/10.1016/j.jmb.2020.03.012" @default.
• W3011657264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32199984" @default.
• W3011657264 hasPublicationYear "2020" @default.
• W3011657264 type Work @default.
• W3011657264 sameAs 3011657264 @default.
• W3011657264 citedByCount "11" @default.
• W3011657264 countsByYear W30116572642021 @default.
• W3011657264 countsByYear W30116572642022 @default.
• W3011657264 countsByYear W30116572642023 @default.
• W3011657264 crossrefType "journal-article" @default.
• W3011657264 hasAuthorship W3011657264A5005553582 @default.
• W3011657264 hasAuthorship W3011657264A5009609494 @default.
• W3011657264 hasAuthorship W3011657264A5025940446 @default.
• W3011657264 hasAuthorship W3011657264A5086296055 @default.
• W3011657264 hasConcept C104317684 @default.
• W3011657264 hasConcept C12554922 @default.
• W3011657264 hasConcept C14036430 @default.
• W3011657264 hasConcept C1491633281 @default.
• W3011657264 hasConcept C16318435 @default.
• W3011657264 hasConcept C166014724 @default.
• W3011657264 hasConcept C185592680 @default.
• W3011657264 hasConcept C205365616 @default.
• W3011657264 hasConcept C41625074 @default.
• W3011657264 hasConcept C501734568 @default.
• W3011657264 hasConcept C51785407 @default.
• W3011657264 hasConcept C55493867 @default.
• W3011657264 hasConcept C70721500 @default.
• W3011657264 hasConcept C85813293 @default.
• W3011657264 hasConcept C86803240 @default.
• W3011657264 hasConcept C95444343 @default.
• W3011657264 hasConceptScore W3011657264C104317684 @default.
• W3011657264 hasConceptScore W3011657264C12554922 @default.
• W3011657264 hasConceptScore W3011657264C14036430 @default.
• W3011657264 hasConceptScore W3011657264C1491633281 @default.
• W3011657264 hasConceptScore W3011657264C16318435 @default.
• W3011657264 hasConceptScore W3011657264C166014724 @default.
• W3011657264 hasConceptScore W3011657264C185592680 @default.
• W3011657264 hasConceptScore W3011657264C205365616 @default.
• W3011657264 hasConceptScore W3011657264C41625074 @default.
• W3011657264 hasConceptScore W3011657264C501734568 @default.
• W3011657264 hasConceptScore W3011657264C51785407 @default.
• W3011657264 hasConceptScore W3011657264C55493867 @default.
• W3011657264 hasConceptScore W3011657264C70721500 @default.
• W3011657264 hasConceptScore W3011657264C85813293 @default.
• W3011657264 hasConceptScore W3011657264C86803240 @default.
• W3011657264 hasConceptScore W3011657264C95444343 @default.

• next