FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011722662> ?p ?o ?g. }

• W3011722662 endingPage "109059" @default.
• W3011722662 startingPage "109059" @default.
• W3011722662 abstract "Fatty liver is the earliest and most common response of the liver to consumption of excessive alcohol. Steatosis can predispose the fatty liver to develop progressive liver damage. Chief among the many mechanisms involved in development of hepatic steatosis is dysregulation of insulin-mediated adipose tissue metabolism. Particularly, it is the enhanced adipose lipolysis-derived free fatty acids and their delivery to the liver that ultimately results in hepatic steatosis. The adipose-liver axis is modulated by hormones, particularly insulin and adiponectin. In recent studies, we demonstrated that an alcohol-induced increase in serum ghrelin levels impairs insulin secretion from pancreatic β-cells. The consequent reduction in circulating insulin levels promotes adipose lipolysis and mobilization of fatty acids to the liver to ultimately contribute to hepatic steatosis. Because many tissues, including adipose tissue, express ghrelin receptor we hypothesized that ghrelin may directly affect energy metabolism in adipocytes. We have exciting new preliminary data which shows that treatment of premature 3T3-L1 adipocytes with ghrelin impairs adipocyte differentiation and inhibits lipid accumulation in the tissue designed to store energy in the form of fat. We further observed that ghrelin treatment of differentiated adipocytes significantly inhibited secretion of adiponectin, a hepatoprotective hormone that reduces lipid synthesis and promotes lipid oxidation. These results were corroborated by our observations of a significant increase in serum adiponectin levels in ethanol-fed rats treated with a ghrelin receptor antagonist verses the un-treated ethanol-fed rats. Interestingly, in adipocytes, ghrelin also increases secretion of interleukin-6 (IL-6) and CCL2 (chemokine [C-C motif] ligand 2), cytokines which promote hepatic inflammation and progression of liver disease. To summarize, the alcohol-induced increase in serum ghrelin levels dysregulates adipose-liver interaction and promotes hepatic steatosis by increasing the free fatty acid released from adipose for hepatic uptake, and by altering adiponectin and cytokine secretion. Taken together, our data indicates that targeting the activity of ghrelin may be a powerful treatment strategy." @default.
• W3011722662 created "2020-03-23" @default.
• W3011722662 creator A5017323780 @default.
• W3011722662 creator A5022129146 @default.
• W3011722662 creator A5023121865 @default.
• W3011722662 creator A5038072918 @default.
• W3011722662 creator A5054848607 @default.
• W3011722662 creator A5073646005 @default.
• W3011722662 date "2020-05-01" @default.
• W3011722662 modified "2023-09-23" @default.
• W3011722662 title "Ghrelin regulates adipose tissue metabolism: Role in hepatic steatosis" @default.
• W3011722662 cites W1488770426 @default.
• W3011722662 cites W1556198709 @default.
• W3011722662 cites W1592119877 @default.
• W3011722662 cites W1970203534 @default.
• W3011722662 cites W1971762417 @default.
• W3011722662 cites W1973848277 @default.
• W3011722662 cites W1974599416 @default.
• W3011722662 cites W1975055822 @default.
• W3011722662 cites W1975927677 @default.
• W3011722662 cites W1976060830 @default.
• W3011722662 cites W1977779461 @default.
• W3011722662 cites W1978690375 @default.
• W3011722662 cites W1990502633 @default.
• W3011722662 cites W2010139869 @default.
• W3011722662 cites W2014887370 @default.
• W3011722662 cites W2019190598 @default.
• W3011722662 cites W2041643170 @default.
• W3011722662 cites W2043335917 @default.
• W3011722662 cites W2054317363 @default.
• W3011722662 cites W2059687832 @default.
• W3011722662 cites W2066238144 @default.
• W3011722662 cites W2068865401 @default.
• W3011722662 cites W2074366941 @default.
• W3011722662 cites W2076458548 @default.
• W3011722662 cites W2080137002 @default.
• W3011722662 cites W2088801812 @default.
• W3011722662 cites W2093628748 @default.
• W3011722662 cites W2093856697 @default.
• W3011722662 cites W2095958622 @default.
• W3011722662 cites W2096690310 @default.
• W3011722662 cites W2097544331 @default.
• W3011722662 cites W2099085608 @default.
• W3011722662 cites W2115134746 @default.
• W3011722662 cites W2134100561 @default.
• W3011722662 cites W2138869320 @default.
• W3011722662 cites W2140695384 @default.
• W3011722662 cites W2151773967 @default.
• W3011722662 cites W2157559566 @default.
• W3011722662 cites W2162286830 @default.
• W3011722662 cites W2163678936 @default.
• W3011722662 cites W2168526937 @default.
• W3011722662 cites W2170831952 @default.
• W3011722662 cites W2256534726 @default.
• W3011722662 cites W2588320067 @default.
• W3011722662 cites W2755471853 @default.
• W3011722662 cites W2790342954 @default.
• W3011722662 cites W2911718219 @default.
• W3011722662 cites W2974000281 @default.
• W3011722662 cites W4237813261 @default.
• W3011722662 cites W4250725029 @default.
• W3011722662 doi "https://doi.org/10.1016/j.cbi.2020.109059" @default.
• W3011722662 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7716754" @default.
• W3011722662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32171850" @default.
• W3011722662 hasPublicationYear "2020" @default.
• W3011722662 type Work @default.
• W3011722662 sameAs 3011722662 @default.
• W3011722662 citedByCount "8" @default.
• W3011722662 countsByYear W30117226622020 @default.
• W3011722662 countsByYear W30117226622021 @default.
• W3011722662 countsByYear W30117226622022 @default.
• W3011722662 countsByYear W30117226622023 @default.
• W3011722662 crossrefType "journal-article" @default.
• W3011722662 hasAuthorship W3011722662A5017323780 @default.
• W3011722662 hasAuthorship W3011722662A5022129146 @default.
• W3011722662 hasAuthorship W3011722662A5023121865 @default.
• W3011722662 hasAuthorship W3011722662A5038072918 @default.
• W3011722662 hasAuthorship W3011722662A5054848607 @default.
• W3011722662 hasAuthorship W3011722662A5073646005 @default.
• W3011722662 hasBestOaLocation W30117226622 @default.
• W3011722662 hasConcept C126322002 @default.
• W3011722662 hasConcept C134018914 @default.
• W3011722662 hasConcept C140985366 @default.
• W3011722662 hasConcept C151955695 @default.
• W3011722662 hasConcept C171089720 @default.
• W3011722662 hasConcept C185592680 @default.
• W3011722662 hasConcept C2776175234 @default.
• W3011722662 hasConcept C2776175330 @default.
• W3011722662 hasConcept C2776782570 @default.
• W3011722662 hasConcept C2777391703 @default.
• W3011722662 hasConcept C2778772119 @default.
• W3011722662 hasConcept C2779134260 @default.
• W3011722662 hasConcept C2779306644 @default.
• W3011722662 hasConcept C2779357093 @default.
• W3011722662 hasConcept C4733338 @default.
• W3011722662 hasConcept C71315377 @default.
• W3011722662 hasConcept C71924100 @default.
• W3011722662 hasConcept C86803240 @default.

• next