Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011741634> ?p ?o ?g. }
- W3011741634 abstract "Mitochondria adapt to cellular needs by changes in morphology through fusion and fission events, referred to as mitochondrial dynamics. Mitochondrial function and morphology are intimately connected and the dysregulation of mitochondrial dynamics is linked to several human diseases. In this work, we investigated the role of mitochondrial dynamics in wound healing in the Drosophila embryonic epidermis. Mutants for mitochondrial fusion and fission proteins fail to close their wounds, indicating that the regulation of mitochondrial dynamics is required for wound healing. By live-imaging, we found that loss of function of the mitochondrial fission protein Dynamin-related protein 1 (Drp1) compromises the increase of cytosolic and mitochondrial calcium upon wounding and leads to reduced reactive oxygen species (ROS) production and F-actin defects at the wound edge, culminating in wound healing impairment. Our results highlight a new role for mitochondrial dynamics in the regulation of calcium, ROS and F-actin during epithelial repair." @default.
- W3011741634 created "2020-03-23" @default.
- W3011741634 creator A5017835758 @default.
- W3011741634 creator A5037190302 @default.
- W3011741634 creator A5068771969 @default.
- W3011741634 creator A5071781624 @default.
- W3011741634 creator A5072661653 @default.
- W3011741634 creator A5073786010 @default.
- W3011741634 date "2020-01-01" @default.
- W3011741634 modified "2023-10-16" @default.
- W3011741634 title "Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing" @default.
- W3011741634 cites W118113528 @default.
- W3011741634 cites W1493752155 @default.
- W3011741634 cites W1562655948 @default.
- W3011741634 cites W1911021731 @default.
- W3011741634 cites W1965627609 @default.
- W3011741634 cites W1966698923 @default.
- W3011741634 cites W1969709153 @default.
- W3011741634 cites W1972476228 @default.
- W3011741634 cites W1972507748 @default.
- W3011741634 cites W1976263925 @default.
- W3011741634 cites W1976267533 @default.
- W3011741634 cites W1978268445 @default.
- W3011741634 cites W1978372269 @default.
- W3011741634 cites W1979600479 @default.
- W3011741634 cites W1980040451 @default.
- W3011741634 cites W1981566818 @default.
- W3011741634 cites W1985231173 @default.
- W3011741634 cites W1986996580 @default.
- W3011741634 cites W1994042842 @default.
- W3011741634 cites W2001707679 @default.
- W3011741634 cites W2002356275 @default.
- W3011741634 cites W2002611364 @default.
- W3011741634 cites W2007353065 @default.
- W3011741634 cites W2016581978 @default.
- W3011741634 cites W2031529753 @default.
- W3011741634 cites W2032295238 @default.
- W3011741634 cites W2033673006 @default.
- W3011741634 cites W2037871836 @default.
- W3011741634 cites W2047931479 @default.
- W3011741634 cites W2052109549 @default.
- W3011741634 cites W2056240884 @default.
- W3011741634 cites W2058397178 @default.
- W3011741634 cites W2064489682 @default.
- W3011741634 cites W2072081532 @default.
- W3011741634 cites W2073006837 @default.
- W3011741634 cites W2073095545 @default.
- W3011741634 cites W2082970812 @default.
- W3011741634 cites W2083054776 @default.
- W3011741634 cites W2086985378 @default.
- W3011741634 cites W2087238801 @default.
- W3011741634 cites W2089774369 @default.
- W3011741634 cites W2094162211 @default.
- W3011741634 cites W2101281572 @default.
- W3011741634 cites W2103046819 @default.
- W3011741634 cites W2103183026 @default.
- W3011741634 cites W2109692759 @default.
- W3011741634 cites W2109748156 @default.
- W3011741634 cites W2110941264 @default.
- W3011741634 cites W2111344409 @default.
- W3011741634 cites W2113417381 @default.
- W3011741634 cites W2115470184 @default.
- W3011741634 cites W2117041194 @default.
- W3011741634 cites W2119956853 @default.
- W3011741634 cites W2122341467 @default.
- W3011741634 cites W2123779991 @default.
- W3011741634 cites W2124540225 @default.
- W3011741634 cites W2126624770 @default.
- W3011741634 cites W2131179754 @default.
- W3011741634 cites W2131415852 @default.
- W3011741634 cites W2133852157 @default.
- W3011741634 cites W2138608772 @default.
- W3011741634 cites W2142830401 @default.
- W3011741634 cites W2143688500 @default.
- W3011741634 cites W2149092784 @default.
- W3011741634 cites W2153456027 @default.
- W3011741634 cites W2154328299 @default.
- W3011741634 cites W2155643523 @default.
- W3011741634 cites W2156333647 @default.
- W3011741634 cites W2156754173 @default.
- W3011741634 cites W2163949267 @default.
- W3011741634 cites W2165283489 @default.
- W3011741634 cites W2167279371 @default.
- W3011741634 cites W2171332611 @default.
- W3011741634 cites W2200229144 @default.
- W3011741634 cites W2229506676 @default.
- W3011741634 cites W2282761819 @default.
- W3011741634 cites W2472693251 @default.
- W3011741634 cites W2480386333 @default.
- W3011741634 cites W2508701503 @default.
- W3011741634 cites W2536622399 @default.
- W3011741634 cites W2565207773 @default.
- W3011741634 cites W2572344066 @default.
- W3011741634 cites W2605465471 @default.
- W3011741634 cites W2758114727 @default.
- W3011741634 cites W2773880766 @default.
- W3011741634 cites W2803259404 @default.
- W3011741634 cites W2883340199 @default.
- W3011741634 cites W2891386047 @default.
- W3011741634 cites W2898204371 @default.