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- W3011746671 abstract "Abstract Background Loeys-Dietz syndrome (LDS) is a systemic connective tissue disease (CTD) associated with a predisposition for intestinal inflammation, food allergy, and failure to thrive, often necessitating nutritional supplementation via gastrostomy tube. Poor wound healing has also been observed in in some patients with CTD, potentially increasing the risk of surgical interventions. We undertook to determine the safety and efficacy of gastrostomy tube placement in this population. Methods We performed a retrospective cohort study of 10 LDS patients who had a total of 12 gastrostomy tubes placed. Results No procedural complications occurred, although one patient developed buried bumper syndrome in the near post-procedural time period and one patient had a small abscess at a surgical stitch. Most patients exhibited improvements in growth, with a median immediate improvement in BMI Z-score of 0.2 per month following the institution of gastrostomy tube feedings. Those with uncontrolled inflammation due to inflammatory bowel disease or eosinophilic gastrointestinal disease showed the least benefit and in some cases failed to demonstrate significant weight gain despite nutritional supplementation. Conclusions Gastrostomy tube placement (surgical or endoscopic) is a generally safe and a reasonable therapeutic option for patients with LDS despite their underlying CTD." @default.
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- W3011746671 date "2020-03-12" @default.
- W3011746671 modified "2023-10-08" @default.
- W3011746671 title "Safety and outcome of gastrostomy tube placement in patients with Loeys-Dietz syndrome" @default.
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- W3011746671 doi "https://doi.org/10.1186/s12876-020-01213-2" @default.
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