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- W3011805145 endingPage "103373" @default.
- W3011805145 startingPage "103373" @default.
- W3011805145 abstract "Bisphenol A (BPA) is considered as ubiquitous xenooestrogen and an endocrine disrupting chemical which has deleterious effects on endocrine functions. Human populations are continuously exposed to BPA as it is abundant in daily life. It has been found to be associated with wide range of metabolic disorders notably type 2 diabetes mellitus (DM). Numerous epidemiological studies have been conducted to find its role in development of DM. Experimental studies have found that BPA exposure is associated with pathogenesis of DM and also considered as a risk factor for gestational diabetes. Being a lipophilic compound, BPA is preferably accumulated in adipose tissues where it alters the production of adipokines that play important roles in insulin resistance. BPA induces apoptosis by caspase activation after mitochondrial damage and it impairs insulin signaling pathways by altering associated ion channel activity especially potassium channels. Perinatal exposure of BPA makes offspring more susceptible to develop DM in early years. Epigenetic modifications are the key mechanisms for BPA-induced metabolic re-programming, where BPA alters the expression of DNA methyltransferases involved in methylation of various genes. In this way, DNA methyltransferase controls the expression of numerous genes including genes important for insulin secretion and signaling. Furthermore, BPA induces histone modifications and alters miRNA expression. In this article, we have briefly described the sources of BPA exposure to human being and summarized the evidence from epidemiological studies linking DM with BPA exposure. Additionally, we have also highlighted the potential molecular pathways for BPA-induced DM." @default.
- W3011805145 created "2020-03-23" @default.
- W3011805145 creator A5003371429 @default.
- W3011805145 creator A5005876838 @default.
- W3011805145 creator A5039116948 @default.
- W3011805145 date "2020-07-01" @default.
- W3011805145 modified "2023-10-06" @default.
- W3011805145 title "Bisphenol A-induced metabolic disorders: From exposure to mechanism of action" @default.
- W3011805145 cites W116732461 @default.
- W3011805145 cites W1502992048 @default.
- W3011805145 cites W1538946518 @default.
- W3011805145 cites W1545124358 @default.
- W3011805145 cites W1646497768 @default.
- W3011805145 cites W1804999886 @default.
- W3011805145 cites W1825306297 @default.
- W3011805145 cites W183357877 @default.
- W3011805145 cites W1840227191 @default.
- W3011805145 cites W187623598 @default.
- W3011805145 cites W1953905519 @default.
- W3011805145 cites W1966411110 @default.
- W3011805145 cites W1966684545 @default.
- W3011805145 cites W1968705853 @default.
- W3011805145 cites W1969191244 @default.
- W3011805145 cites W1970358298 @default.
- W3011805145 cites W1971947104 @default.
- W3011805145 cites W1975998449 @default.
- W3011805145 cites W1980715192 @default.
- W3011805145 cites W1982404766 @default.
- W3011805145 cites W1983557204 @default.
- W3011805145 cites W1983953582 @default.
- W3011805145 cites W1985941840 @default.
- W3011805145 cites W1986045251 @default.
- W3011805145 cites W1989954597 @default.
- W3011805145 cites W1990117176 @default.
- W3011805145 cites W1991626426 @default.
- W3011805145 cites W1995064889 @default.
- W3011805145 cites W1996857104 @default.
- W3011805145 cites W2003551375 @default.
- W3011805145 cites W2003560810 @default.
- W3011805145 cites W2003992236 @default.
- W3011805145 cites W2007975243 @default.
- W3011805145 cites W2011910390 @default.
- W3011805145 cites W2012740498 @default.
- W3011805145 cites W2015429374 @default.
- W3011805145 cites W2026175834 @default.
- W3011805145 cites W2026514466 @default.
- W3011805145 cites W2026835968 @default.
- W3011805145 cites W2028071281 @default.
- W3011805145 cites W2030400065 @default.
- W3011805145 cites W2032528488 @default.
- W3011805145 cites W2032941638 @default.
- W3011805145 cites W2033211255 @default.
- W3011805145 cites W2037510660 @default.
- W3011805145 cites W2037728383 @default.
- W3011805145 cites W2038182524 @default.
- W3011805145 cites W2038381362 @default.
- W3011805145 cites W2040945764 @default.
- W3011805145 cites W2041693476 @default.
- W3011805145 cites W2041717284 @default.
- W3011805145 cites W2046318060 @default.
- W3011805145 cites W2046357173 @default.
- W3011805145 cites W2047523002 @default.
- W3011805145 cites W2053570362 @default.
- W3011805145 cites W2054433134 @default.
- W3011805145 cites W2061567223 @default.
- W3011805145 cites W2062520652 @default.
- W3011805145 cites W2066858562 @default.
- W3011805145 cites W2067753015 @default.
- W3011805145 cites W2068630231 @default.
- W3011805145 cites W2069993483 @default.
- W3011805145 cites W2070374246 @default.
- W3011805145 cites W2072345180 @default.
- W3011805145 cites W2073116679 @default.
- W3011805145 cites W2077342495 @default.
- W3011805145 cites W2077411765 @default.
- W3011805145 cites W2077511269 @default.
- W3011805145 cites W2079217745 @default.
- W3011805145 cites W2081704559 @default.
- W3011805145 cites W2085198532 @default.
- W3011805145 cites W2088514819 @default.
- W3011805145 cites W2090637770 @default.
- W3011805145 cites W2093544756 @default.
- W3011805145 cites W2094649259 @default.
- W3011805145 cites W2099737810 @default.
- W3011805145 cites W2100887303 @default.
- W3011805145 cites W2101870887 @default.
- W3011805145 cites W2104151989 @default.
- W3011805145 cites W2104276917 @default.
- W3011805145 cites W2108116137 @default.
- W3011805145 cites W2108900261 @default.
- W3011805145 cites W2110952210 @default.
- W3011805145 cites W2111631040 @default.
- W3011805145 cites W2113644293 @default.
- W3011805145 cites W2114899481 @default.
- W3011805145 cites W2117831463 @default.
- W3011805145 cites W2119352549 @default.
- W3011805145 cites W2125089843 @default.
- W3011805145 cites W2128482911 @default.