Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011844105> ?p ?o ?g. }
- W3011844105 endingPage "484" @default.
- W3011844105 startingPage "473" @default.
- W3011844105 abstract "All living organisms are unavoidably exposed to various endogenous and environmental stresses that trigger potentially fatal DNA damage, including double-strand breaks (DSBs). Although a growing body of evidence indicates that DNA damage is one of the prime drivers of aging in animals, little is known regarding the importance of DNA damage and its repair on lifespan control in plants. We found that the level of DSBs increases but DNA repair efficiency decreases as Arabidopsis leaves age. Generation of DSBs by inducible expression of I-PpoI leads to premature senescence phenotypes. We examined the senescence phenotypes in the loss-of-function mutants for 13 key components of the DNA repair pathway and found that deficiency in ATAXIA TELANGIECTASIA MUTATED (ATM), the chief transducer of the DSB signal, results in premature senescence in Arabidopsis. ATM represses DSB-induced expression of senescence-associated genes, including the genes encoding the WRKY and NAC transcription factors, central components of the leaf senescence process, via modulation of histone lysine methylation. Our work highlights the significance of ATM in the control of leaf senescence and has significant implications for the conservation of aging mechanisms in animals and plants." @default.
- W3011844105 created "2020-03-23" @default.
- W3011844105 creator A5014969495 @default.
- W3011844105 creator A5043899074 @default.
- W3011844105 creator A5044544424 @default.
- W3011844105 creator A5046173207 @default.
- W3011844105 creator A5062852652 @default.
- W3011844105 creator A5075729175 @default.
- W3011844105 creator A5078809545 @default.
- W3011844105 creator A5083365266 @default.
- W3011844105 date "2020-04-22" @default.
- W3011844105 modified "2023-10-15" @default.
- W3011844105 title "ATM suppresses leaf senescence triggered by DNA double‐strand break through epigenetic control of senescence‐associated genes in <i>Arabidopsis</i>" @default.
- W3011844105 cites W1505820433 @default.
- W3011844105 cites W1888520698 @default.
- W3011844105 cites W1969092339 @default.
- W3011844105 cites W1979003807 @default.
- W3011844105 cites W1984318436 @default.
- W3011844105 cites W1989458057 @default.
- W3011844105 cites W1989665806 @default.
- W3011844105 cites W2002982974 @default.
- W3011844105 cites W2016246105 @default.
- W3011844105 cites W2016553165 @default.
- W3011844105 cites W2021689905 @default.
- W3011844105 cites W2022572059 @default.
- W3011844105 cites W2030132680 @default.
- W3011844105 cites W2045188214 @default.
- W3011844105 cites W2046589688 @default.
- W3011844105 cites W2048442759 @default.
- W3011844105 cites W2054123861 @default.
- W3011844105 cites W2055531681 @default.
- W3011844105 cites W2059658112 @default.
- W3011844105 cites W2063268362 @default.
- W3011844105 cites W2063269133 @default.
- W3011844105 cites W2071050165 @default.
- W3011844105 cites W2071062820 @default.
- W3011844105 cites W2071457560 @default.
- W3011844105 cites W2073101700 @default.
- W3011844105 cites W2080842750 @default.
- W3011844105 cites W2107274287 @default.
- W3011844105 cites W2114342948 @default.
- W3011844105 cites W2115796098 @default.
- W3011844105 cites W2116082487 @default.
- W3011844105 cites W2116122104 @default.
- W3011844105 cites W2118514901 @default.
- W3011844105 cites W2119686296 @default.
- W3011844105 cites W2123285456 @default.
- W3011844105 cites W2126128820 @default.
- W3011844105 cites W2126684428 @default.
- W3011844105 cites W2128084403 @default.
- W3011844105 cites W2132792723 @default.
- W3011844105 cites W2134603675 @default.
- W3011844105 cites W2140154770 @default.
- W3011844105 cites W2141013052 @default.
- W3011844105 cites W2144171940 @default.
- W3011844105 cites W2146010728 @default.
- W3011844105 cites W2146281024 @default.
- W3011844105 cites W2147410675 @default.
- W3011844105 cites W2148937130 @default.
- W3011844105 cites W2151066815 @default.
- W3011844105 cites W2153978704 @default.
- W3011844105 cites W2159168998 @default.
- W3011844105 cites W2255462063 @default.
- W3011844105 cites W2275359829 @default.
- W3011844105 cites W2293719222 @default.
- W3011844105 cites W2345347915 @default.
- W3011844105 cites W2436176171 @default.
- W3011844105 cites W2513448306 @default.
- W3011844105 cites W2514271666 @default.
- W3011844105 cites W2598437549 @default.
- W3011844105 cites W2615489352 @default.
- W3011844105 cites W2801799722 @default.
- W3011844105 cites W4247878281 @default.
- W3011844105 doi "https://doi.org/10.1111/nph.16535" @default.
- W3011844105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32163596" @default.
- W3011844105 hasPublicationYear "2020" @default.
- W3011844105 type Work @default.
- W3011844105 sameAs 3011844105 @default.
- W3011844105 citedByCount "24" @default.
- W3011844105 countsByYear W30118441052020 @default.
- W3011844105 countsByYear W30118441052021 @default.
- W3011844105 countsByYear W30118441052022 @default.
- W3011844105 countsByYear W30118441052023 @default.
- W3011844105 crossrefType "journal-article" @default.
- W3011844105 hasAuthorship W3011844105A5014969495 @default.
- W3011844105 hasAuthorship W3011844105A5043899074 @default.
- W3011844105 hasAuthorship W3011844105A5044544424 @default.
- W3011844105 hasAuthorship W3011844105A5046173207 @default.
- W3011844105 hasAuthorship W3011844105A5062852652 @default.
- W3011844105 hasAuthorship W3011844105A5075729175 @default.
- W3011844105 hasAuthorship W3011844105A5078809545 @default.
- W3011844105 hasAuthorship W3011844105A5083365266 @default.
- W3011844105 hasBestOaLocation W30118441051 @default.
- W3011844105 hasConcept C104317684 @default.
- W3011844105 hasConcept C134935766 @default.
- W3011844105 hasConcept C143065580 @default.
- W3011844105 hasConcept C143425029 @default.
- W3011844105 hasConcept C177336024 @default.