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• W3011854888 abstract "The cytotoxicity of epitope-specific CD8+ T cells is usually measured indirectly through IFNγ production. Existing assays that directly measure this activity are limited mainly to measurements of up to two specificities in a single reaction. Here, we develop a multiplex cytotoxicity assay that allows direct, simultaneous measurement of up to 23 different specificities of CD8+ T cells in a single reaction. This can greatly reduce the amount of starting clinical materials for a systematic screening of CD8+ T cell epiptopes. In addition, this greatly enhanced capacity enables the incorporation of irrelevant epitopes for determining the non-specific killing activity of CD8+ T cells, thereby allowing to measure the actual epitope-specific cytotoxicity activities. This technique is shown to be useful to study both human and mouse CD8+ T cells. Besides, our results from human PBMCs and three independent infectious animal models (MERS, influenza and malaria) further reveal that IFNγ expression by epitope-specific CD8+ T cells does not always correlate with their cell-killing potential, highlighting the need for using cytotoxicity assays in specific contexts (e.g., evaluating vaccine candidates). Overall, our approach opens up new possibilities for comprehensive analyses of CD8+ T cell cytotoxicity in a practical manner." @default.
• W3011854888 created "2020-03-23" @default.
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• W3011854888 date "2020-03-11" @default.
• W3011854888 modified "2023-10-02" @default.
• W3011854888 title "Multiplex Screening Assay for Identifying Cytotoxic CD8+ T Cell Epitopes" @default.
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• W3011854888 doi "https://doi.org/10.3389/fimmu.2020.00400" @default.
• W3011854888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7078160" @default.
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