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- W3011928423 endingPage "729" @default.
- W3011928423 startingPage "729" @default.
- W3011928423 abstract "Gamma delta T cells (Tc) are divided according to the type of Vδ and Vγ chains they express, with two major γδ Tc subsets being recognized in humans: Vδ2Vγ9 and Vδ1. Despite many studies in pathological conditions, only a few have quantified the γδ Tc subsets in healthy adults, and a comprehensive review of the factors influencing its representation in the blood is missing. Here we quantified the total γδ Tc and the Vδ2/Vγ9 and Vδ1 Tc subsets in the blood from 30 healthy, Caucasian, Portuguese adults, we characterized their immunophenotype by 8-color flow cytometry, focusing in a few relevant Tc markers (CD3/TCR-γδ, CD5, CD8), and costimulatory (CD28), cytotoxic (CD16) and adhesion (CD56) molecules, and we examined the impacts of age and gender. Additionally, we reviewed the literature on the influences of race/ethnicity, age, gender, special periods of life, past infections, diet, medications and concomitant diseases on γδ Tc and their subsets. Given the multitude of factors influencing the γδ Tc repertoire and immunophenotype and the high variation observed, caution should be taken in interpreting “abnormal” γδ Tc values and repertoire deviations, and the clinical significance of small populations of “phenotypically abnormal” γδ Tc in the blood." @default.
- W3011928423 created "2020-03-23" @default.
- W3011928423 creator A5002313965 @default.
- W3011928423 creator A5009509196 @default.
- W3011928423 creator A5021803283 @default.
- W3011928423 creator A5068037509 @default.
- W3011928423 creator A5079000303 @default.
- W3011928423 creator A5090097756 @default.
- W3011928423 date "2020-03-16" @default.
- W3011928423 modified "2023-09-30" @default.
- W3011928423 title "Human Peripheral Blood Gamma Delta T Cells: Report on a Series of Healthy Caucasian Portuguese Adults and Comprehensive Review of the Literature" @default.
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