Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012000503> ?p ?o ?g. }
- W3012000503 endingPage "1172" @default.
- W3012000503 startingPage "1151" @default.
- W3012000503 abstract "Adverse outcome pathways (AOPs) have been recently introduced as tools to map the mechanisms underlying toxic events relevant for chemical risk assessment. AOPs particularly depict the linkage between a molecular initiating event and an adverse outcome through a number of intermediate key events. An AOP has been previously introduced for cholestatic liver injury. The objective of this study was to test the robustness of this AOP for different types of cholestatic insult and the in vitro to in vivo extrapolation. For this purpose, in vitro samples from human hepatoma HepaRG cell cultures were exposed to cholestatic drugs (i.e. intrahepatic cholestasis), while in vivo samples were obtained from livers of cholestatic mice (i.e. extrahepatic cholestasis). The occurrence of cholestasis in vitro was confirmed through analysis of bile transporter functionality and bile acid analysis. Transcriptomic analysis revealed inflammation and oxidative stress as key events in both types of cholestatic liver injury. Major transcriptional differences between intrahepatic and extrahepatic cholestatic liver insults were observed at the level of cell death and metabolism. Novel key events identified by pathway analysis included endoplasmic reticulum stress in intrahepatic cholestasis, and autophagy and necroptosis in both intrahepatic as extrahepatic cholestasis. This study demonstrates that AOPs constitute dynamic tools that should be frequently updated with new input information." @default.
- W3012000503 created "2020-03-23" @default.
- W3012000503 creator A5010159317 @default.
- W3012000503 creator A5022384436 @default.
- W3012000503 creator A5023428926 @default.
- W3012000503 creator A5034833350 @default.
- W3012000503 creator A5041322811 @default.
- W3012000503 creator A5045862213 @default.
- W3012000503 date "2020-03-10" @default.
- W3012000503 modified "2023-10-01" @default.
- W3012000503 title "Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury" @default.
- W3012000503 cites W179356329 @default.
- W3012000503 cites W1847765510 @default.
- W3012000503 cites W1966514588 @default.
- W3012000503 cites W1976772672 @default.
- W3012000503 cites W1976811057 @default.
- W3012000503 cites W1997652842 @default.
- W3012000503 cites W1999169119 @default.
- W3012000503 cites W2000089305 @default.
- W3012000503 cites W2011281620 @default.
- W3012000503 cites W2021878099 @default.
- W3012000503 cites W2022589185 @default.
- W3012000503 cites W2029004157 @default.
- W3012000503 cites W2032329090 @default.
- W3012000503 cites W2033440519 @default.
- W3012000503 cites W2041335894 @default.
- W3012000503 cites W2041827858 @default.
- W3012000503 cites W2046470405 @default.
- W3012000503 cites W2048876828 @default.
- W3012000503 cites W2052356187 @default.
- W3012000503 cites W2066453798 @default.
- W3012000503 cites W2066663277 @default.
- W3012000503 cites W2069369799 @default.
- W3012000503 cites W2075308015 @default.
- W3012000503 cites W2092960198 @default.
- W3012000503 cites W2093277109 @default.
- W3012000503 cites W2096210798 @default.
- W3012000503 cites W2100414335 @default.
- W3012000503 cites W2105593895 @default.
- W3012000503 cites W2110942596 @default.
- W3012000503 cites W2116116003 @default.
- W3012000503 cites W2119461551 @default.
- W3012000503 cites W2121541608 @default.
- W3012000503 cites W2134837921 @default.
- W3012000503 cites W2135714813 @default.
- W3012000503 cites W2136784816 @default.
- W3012000503 cites W2153238893 @default.
- W3012000503 cites W2157160726 @default.
- W3012000503 cites W2160289440 @default.
- W3012000503 cites W2161771297 @default.
- W3012000503 cites W2162846070 @default.
- W3012000503 cites W2171579258 @default.
- W3012000503 cites W2302952418 @default.
- W3012000503 cites W2313757172 @default.
- W3012000503 cites W2321481726 @default.
- W3012000503 cites W2472013204 @default.
- W3012000503 cites W2484076742 @default.
- W3012000503 cites W2524235891 @default.
- W3012000503 cites W2539243243 @default.
- W3012000503 cites W2559873150 @default.
- W3012000503 cites W2593557173 @default.
- W3012000503 cites W2598194157 @default.
- W3012000503 cites W2734346062 @default.
- W3012000503 cites W2755407398 @default.
- W3012000503 cites W2756467300 @default.
- W3012000503 cites W2774928962 @default.
- W3012000503 cites W2793287213 @default.
- W3012000503 cites W2802406017 @default.
- W3012000503 cites W2887171645 @default.
- W3012000503 cites W2936376796 @default.
- W3012000503 cites W2941772899 @default.
- W3012000503 cites W2942450853 @default.
- W3012000503 cites W2948360372 @default.
- W3012000503 cites W4238094155 @default.
- W3012000503 cites W4256106143 @default.
- W3012000503 cites W67122117 @default.
- W3012000503 doi "https://doi.org/10.1007/s00204-020-02691-9" @default.
- W3012000503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32152650" @default.
- W3012000503 hasPublicationYear "2020" @default.
- W3012000503 type Work @default.
- W3012000503 sameAs 3012000503 @default.
- W3012000503 citedByCount "27" @default.
- W3012000503 countsByYear W30120005032020 @default.
- W3012000503 countsByYear W30120005032021 @default.
- W3012000503 countsByYear W30120005032022 @default.
- W3012000503 countsByYear W30120005032023 @default.
- W3012000503 crossrefType "journal-article" @default.
- W3012000503 hasAuthorship W3012000503A5010159317 @default.
- W3012000503 hasAuthorship W3012000503A5022384436 @default.
- W3012000503 hasAuthorship W3012000503A5023428926 @default.
- W3012000503 hasAuthorship W3012000503A5034833350 @default.
- W3012000503 hasAuthorship W3012000503A5041322811 @default.
- W3012000503 hasAuthorship W3012000503A5045862213 @default.
- W3012000503 hasBestOaLocation W30120005032 @default.
- W3012000503 hasConcept C126322002 @default.
- W3012000503 hasConcept C150903083 @default.
- W3012000503 hasConcept C190283241 @default.
- W3012000503 hasConcept C197934379 @default.