FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012034861> ?p ?o ?g. }

• W3012034861 abstract "Accumulating evidence showed that Interleukin (IL) level is associated with Osteoporosis. Whereas, most of these associations are based on observational studies. Thus, their causality was still unclear. Mendelian randomization (MR) is a widely used statistical framework that uses genetic instrumental variables (IVs) to explore the causality of intermediate phenotype with disease. To classify their causality, we conducted a MR analysis to investigate the effect of IL-18 on the risk of Osteoporosis. First, based on summarized genome-wide association study (GWAS) data, 8 independent IL-18 SNPs reaching genome-wide significance were deemed as IVs. Next, Simple median method was used to calculate the pooled odds ratio (OR) of these 8 SNPs for the assessment of IL-8 on the risk of Osteoporosis. Then, MR-Egger regression was utilized to detect potential bias due to the horizontal pleiotropy of these IVs. As a result of simple median method, we get the SE (-0.001; 95% CI -0.002 to 0; P = 0.042), which means low IL-18 level could increase the risk of the development of Osteoporosis. The low intercept (0; 95% CI -0.001 to 0; P = 0.59) shows there is no bias due to the horizontal pleiotropy of the IVs." @default.
• W3012034861 created "2020-03-23" @default.
• W3012034861 creator A5001596219 @default.
• W3012034861 creator A5035073208 @default.
• W3012034861 creator A5043715354 @default.
• W3012034861 creator A5048776489 @default.
• W3012034861 creator A5052926367 @default.
• W3012034861 creator A5065919151 @default.
• W3012034861 creator A5072705483 @default.
• W3012034861 creator A5080508378 @default.
• W3012034861 creator A5085279249 @default.
• W3012034861 date "2020-03-20" @default.
• W3012034861 modified "2023-10-10" @default.
• W3012034861 title "A Mendelian Randomization Analysis to Expose the Causal Effect of IL-18 on Osteoporosis Based on Genome-Wide Association Study Data" @default.
• W3012034861 cites W18924068 @default.
• W3012034861 cites W1968536479 @default.
• W3012034861 cites W1985696762 @default.
• W3012034861 cites W1998640683 @default.
• W3012034861 cites W2055495715 @default.
• W3012034861 cites W2088306841 @default.
• W3012034861 cites W2113699335 @default.
• W3012034861 cites W2302919881 @default.
• W3012034861 cites W2417383277 @default.
• W3012034861 cites W2427122612 @default.
• W3012034861 cites W2549247408 @default.
• W3012034861 cites W2579268832 @default.
• W3012034861 cites W2604799008 @default.
• W3012034861 cites W2616828035 @default.
• W3012034861 cites W2737478665 @default.
• W3012034861 cites W2756148272 @default.
• W3012034861 cites W2769742795 @default.
• W3012034861 cites W2784026193 @default.
• W3012034861 cites W2792533056 @default.
• W3012034861 cites W2794800511 @default.
• W3012034861 cites W2805110914 @default.
• W3012034861 cites W2805983714 @default.
• W3012034861 cites W2810588634 @default.
• W3012034861 cites W2895486342 @default.
• W3012034861 cites W2900329012 @default.
• W3012034861 cites W2905837927 @default.
• W3012034861 cites W2911389042 @default.
• W3012034861 cites W2915321198 @default.
• W3012034861 cites W2923490814 @default.
• W3012034861 cites W2928182402 @default.
• W3012034861 cites W2936144882 @default.
• W3012034861 cites W2948893745 @default.
• W3012034861 cites W2952947622 @default.
• W3012034861 cites W2953520588 @default.
• W3012034861 cites W2954788011 @default.
• W3012034861 cites W2975585537 @default.
• W3012034861 cites W2977235223 @default.
• W3012034861 cites W2979072963 @default.
• W3012034861 cites W2979937512 @default.
• W3012034861 cites W2979992936 @default.
• W3012034861 cites W2981438385 @default.
• W3012034861 cites W2985856177 @default.
• W3012034861 cites W2994725160 @default.
• W3012034861 cites W2995759440 @default.
• W3012034861 cites W3004263072 @default.
• W3012034861 cites W3007150491 @default.
• W3012034861 cites W3012664382 @default.
• W3012034861 cites W4255502791 @default.
• W3012034861 doi "https://doi.org/10.3389/fbioe.2020.00201" @default.
• W3012034861 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7099043" @default.
• W3012034861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32266232" @default.
• W3012034861 hasPublicationYear "2020" @default.
• W3012034861 type Work @default.
• W3012034861 sameAs 3012034861 @default.
• W3012034861 citedByCount "4" @default.
• W3012034861 countsByYear W30120348612021 @default.
• W3012034861 countsByYear W30120348612022 @default.
• W3012034861 countsByYear W30120348612023 @default.
• W3012034861 crossrefType "journal-article" @default.
• W3012034861 hasAuthorship W3012034861A5001596219 @default.
• W3012034861 hasAuthorship W3012034861A5035073208 @default.
• W3012034861 hasAuthorship W3012034861A5043715354 @default.
• W3012034861 hasAuthorship W3012034861A5048776489 @default.
• W3012034861 hasAuthorship W3012034861A5052926367 @default.
• W3012034861 hasAuthorship W3012034861A5065919151 @default.
• W3012034861 hasAuthorship W3012034861A5072705483 @default.
• W3012034861 hasAuthorship W3012034861A5080508378 @default.
• W3012034861 hasAuthorship W3012034861A5085279249 @default.
• W3012034861 hasBestOaLocation W30120348611 @default.
• W3012034861 hasConcept C104317684 @default.
• W3012034861 hasConcept C105795698 @default.
• W3012034861 hasConcept C106208931 @default.
• W3012034861 hasConcept C121332964 @default.
• W3012034861 hasConcept C126322002 @default.
• W3012034861 hasConcept C127716648 @default.
• W3012034861 hasConcept C135763542 @default.
• W3012034861 hasConcept C153209595 @default.
• W3012034861 hasConcept C156957248 @default.
• W3012034861 hasConcept C162144332 @default.
• W3012034861 hasConcept C186413461 @default.
• W3012034861 hasConcept C23131810 @default.
• W3012034861 hasConcept C26207810 @default.
• W3012034861 hasConcept C2776541429 @default.
• W3012034861 hasConcept C2779901538 @default.
• W3012034861 hasConcept C2993967602 @default.
• W3012034861 hasConcept C33923547 @default.

• next