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- W3012040932 abstract "Cultured mammalian cells are the workhorse for the manufacturing of the class of pharmaceuticals known as biologics, including viral vaccines and many protein medicines. Critical to cell culture advances was the arrival of membrane-filtration-based medium sterilization, first by ultrafiltration with a nitrocellulose membrane and later by microfiltration. The arrival of recombinant DNA technology in the 1970s made the production of various protein reagents a simpler task. It expanded the repertoire of biochemical reagents and greatly increased our ability to culture cells that require growth factors and cytokines. The most effective way to fight viral diseases has been widespread immunization by vaccines. The majority of viral vaccines are produced in cell culture. Proteins derived from blood, tissues, and cell cultures were used for therapeutic purposes long before the arrival of recombinant DNA technology. The basic process flowsheet for cell culture manufacturing is almost identical to that for microbial fermentation." @default.
- W3012040932 created "2020-03-23" @default.
- W3012040932 creator A5031550624 @default.
- W3012040932 date "2020-03-06" @default.
- W3012040932 modified "2023-10-18" @default.
- W3012040932 title "Overview of Cell Culture Processes" @default.
- W3012040932 doi "https://doi.org/10.1201/9780429162770-1" @default.
- W3012040932 hasPublicationYear "2020" @default.
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