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- W3012042783 abstract "Abstract Objectives To optimize stimulation parameters for electroretionographic recordings of the multifocal photopic negative response (mfPhNR) for the detection of glaucoma and to compare the diagnostic accuracy of electrophysiological, structural and functional measures of glaucoma. Methods In 24 healthy controls, 10 glaucoma suspects (GLA S ) and 16 glaucoma participants (GLA G ), mfPhNR for 6 different stimulation rates were assessed to compare their discrimination performance. Subsequently, a cross-modal comparison of the mfPhNR/b-wave ratio was performed with pattern electroretinogram (PERG), and peripapillary retinal nerve fiber layer (pRNFL) thickness. These analyses were based on area under curves (AUC) obtained from receiver-operating-characteristics (ROC) analyses and step-wise regression analyses. Results Compared to the other mfPhNR-conditions, the PhNR/b-wave ratio for the fastest stimulation condition had the highest AUC for GLA S (0.84, P = 0.008, 95%CI: 0.71-0.98); the other modalities, i.e., PERG-amplitude and pRNFL had AUCs of 0.77, and 0.74 respectively. pRNFL was the significant predictor for mfPhNR/b-wave ratio [t (48) = 4, P 0.0002]. Conclusions Fast mfPhNR protocols outperform other mf-protocols in the identification of glaucomatous damage especially for GLA S and thus aid the early detection of glaucoma. Significance mfPhNR recordings might serve as surrogate marker of ganglion cell dysfunction especially in glaucoma suspects." @default.
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- W3012042783 date "2020-03-20" @default.
- W3012042783 modified "2023-09-27" @default.
- W3012042783 title "Diagnostic performance of multifocal photopic negative response, pattern electroretinogram and optical coherence tomography in glaucoma" @default.
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- W3012042783 doi "https://doi.org/10.1101/2020.03.18.20034785" @default.
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