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• W3012065601 endingPage "170296" @default.
• W3012065601 startingPage "170296" @default.
• W3012065601 abstract "Diabesity and its related cardio-hepato-renal complications are of absolute concern globally. Last decade has witnessed a growing interest in the scientific community in investigating novel pharmaco-therapies employing the pancreatic hormone, glucagon. Canonically, this polypeptide hormone is known for its use in rescue treatment for hypoglycaemic shocks owing to its involvement in the counter-regulatory feedback mechanism. However, substantial studies in the recent past elucidated the pleiotropic effects of glucagon in diabesity and related complications like non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD). Thus, the dual nature of this peptide has sparked the search for drugs that can modify glucagon signalling to combat hypoglycaemia or diabesity. Thus far, researchers have explored various pharmacological approaches to utilise this peptide in imminent modern therapies. The research endeavours in this segment led to explorations of stable glucagon formulations/analogues, glucagon receptor antagonism, glucagon receptor agonism, and incretin poly-agonism as new strategies for the management of hypoglycaemia or diabesity. This 'three-dimensional' research on glucagon resulted in the discovery of various drug candidates that proficiently modify glucagon signalling. Currently, several emerging glucagon-based therapies are under pre-clinical and clinical development. We sought to summarise the recent progress to comprehend glucagon-mediated pleiotropic effects, provide an overview of drug candidates currently being developed and future perspectives in this research domain." @default.
• W3012065601 created "2020-03-23" @default.
• W3012065601 creator A5000362174 @default.
• W3012065601 creator A5001087787 @default.
• W3012065601 creator A5010695845 @default.
• W3012065601 creator A5054061739 @default.
• W3012065601 date "2020-05-01" @default.
• W3012065601 modified "2023-09-30" @default.
• W3012065601 title "Glucagon-based therapy: Past, present and future" @default.
• W3012065601 cites W1567903119 @default.
• W3012065601 cites W1588301406 @default.
• W3012065601 cites W1969178983 @default.
• W3012065601 cites W1974591474 @default.
• W3012065601 cites W1978425428 @default.
• W3012065601 cites W1995475257 @default.
• W3012065601 cites W2003946536 @default.
• W3012065601 cites W2018647362 @default.
• W3012065601 cites W2021517048 @default.
• W3012065601 cites W2022382384 @default.
• W3012065601 cites W2022902106 @default.
• W3012065601 cites W2025025361 @default.
• W3012065601 cites W2026602923 @default.
• W3012065601 cites W2028502361 @default.
• W3012065601 cites W2029799719 @default.
• W3012065601 cites W2032322539 @default.
• W3012065601 cites W2043889992 @default.
• W3012065601 cites W2046912474 @default.
• W3012065601 cites W2058768686 @default.
• W3012065601 cites W2058811087 @default.
• W3012065601 cites W2069496751 @default.
• W3012065601 cites W2079920392 @default.
• W3012065601 cites W2082024390 @default.
• W3012065601 cites W2097433877 @default.
• W3012065601 cites W2098957321 @default.
• W3012065601 cites W2106407177 @default.
• W3012065601 cites W2111485250 @default.
• W3012065601 cites W2112704642 @default.
• W3012065601 cites W2115939390 @default.
• W3012065601 cites W2122188063 @default.
• W3012065601 cites W2123578975 @default.
• W3012065601 cites W2129983555 @default.
• W3012065601 cites W2132295069 @default.
• W3012065601 cites W2135978651 @default.
• W3012065601 cites W2145233788 @default.
• W3012065601 cites W2148275037 @default.
• W3012065601 cites W2148623180 @default.
• W3012065601 cites W2149717292 @default.
• W3012065601 cites W2154010909 @default.
• W3012065601 cites W2154325494 @default.
• W3012065601 cites W2154785285 @default.
• W3012065601 cites W2158756137 @default.
• W3012065601 cites W2179944903 @default.
• W3012065601 cites W2207556001 @default.
• W3012065601 cites W2215535790 @default.
• W3012065601 cites W2224127549 @default.
• W3012065601 cites W2225754391 @default.
• W3012065601 cites W2236361713 @default.
• W3012065601 cites W2284954176 @default.
• W3012065601 cites W2336523804 @default.
• W3012065601 cites W2342578893 @default.
• W3012065601 cites W2464238397 @default.
• W3012065601 cites W2471889258 @default.
• W3012065601 cites W2472736346 @default.
• W3012065601 cites W2512913340 @default.
• W3012065601 cites W2514133655 @default.
• W3012065601 cites W2518479846 @default.
• W3012065601 cites W2580733813 @default.
• W3012065601 cites W2580793886 @default.
• W3012065601 cites W2583125779 @default.
• W3012065601 cites W2588151434 @default.
• W3012065601 cites W2591832038 @default.
• W3012065601 cites W2600127085 @default.
• W3012065601 cites W2608961189 @default.
• W3012065601 cites W2624087031 @default.
• W3012065601 cites W2737611067 @default.
• W3012065601 cites W2746215644 @default.
• W3012065601 cites W2765700591 @default.
• W3012065601 cites W2766171176 @default.
• W3012065601 cites W2779666226 @default.
• W3012065601 cites W2781395153 @default.
• W3012065601 cites W2785903681 @default.
• W3012065601 cites W2788969344 @default.
• W3012065601 cites W2789001384 @default.
• W3012065601 cites W2792527295 @default.
• W3012065601 cites W2794397832 @default.
• W3012065601 cites W2796095660 @default.
• W3012065601 cites W2797475981 @default.
• W3012065601 cites W2807604754 @default.
• W3012065601 cites W2808030638 @default.
• W3012065601 cites W2808958607 @default.
• W3012065601 cites W2808959426 @default.
• W3012065601 cites W2809586755 @default.
• W3012065601 cites W2815052709 @default.
• W3012065601 cites W2884604241 @default.
• W3012065601 cites W2886911834 @default.
• W3012065601 cites W2889408384 @default.
• W3012065601 cites W2891323571 @default.
• W3012065601 cites W2892037130 @default.

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