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• W3012085989 abstract "Abstract Tumor Mutational Burden (TMB) is a measure of the abundance of somatic mutations in a tumor, which has been shown to be an emerging biomarker for both anti-PD-(L)1 treatment and prognosis; however, multiple challenges still hinder the adoption of TMB as a biomarker. The key challenges are the inconsistency of tumor mutational burden measurement among assays and the lack of a meaningful threshold for TMB classification. Here we describe a new method, ecTMB (Estimation and Classification of TMB), which uses an explicit background mutation model to predict TMB robustly and to classify samples into biologically meaningful subtypes defined by tumor mutational burden." @default.
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• W3012085989 date "2020-03-18" @default.
• W3012085989 modified "2023-09-25" @default.
• W3012085989 title "ecTMB: a robust method to estimate and classify tumor mutational burden" @default.
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• W3012085989 doi "https://doi.org/10.1038/s41598-020-61575-1" @default.
• W3012085989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7080796" @default.
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