Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012087411> ?p ?o ?g. }
- W3012087411 abstract "Abstract Background The human papillomaviruses (HPV) are a group of viruses that, depending on the strain, can cause cancer or the formation of benign growths known as warts. Scarce information exists with regard to the genetic nature of non-genital cutaneous warts induced by the human papillomavirus (HPV). Methods The main purpose of this study is to investigate the differences between the gene expression profiles of common warts and healthy skin in HPV-positive individuals by RNA sequencing on the Illumina HiSeq 2500. After obtaining shave biopsies of common warts and healthy skin from twelve Arab males, we were able to analyze the transcriptomes of 24 paired cases and controls. Results Common warts were found to possess a highly significant and unique molecular signature. Many of the most up-regulated ( KRT16 , EPGN , and ABCG4 ) and down-regulated genes ( C15orf59 , CYB561A3 , and FCGRT ) in warts were the subject of little investigation in the published literature. Moreover, the top 500 differentially expressed genes were found to be associated with immune and autoimmune pathways, such as the neutrophil degranulation, toll-like receptor 7/8 (TLR 7/8) cascade, toll-like receptor 9 (TLR9) cascade, and toll-like receptor 10 (TLR10) pathways, among others. Conclusions Our findings are particularly important because they serve as the most comprehensive to date with regard to the modulation of human skin gene expression by HPV infection." @default.
- W3012087411 created "2020-03-23" @default.
- W3012087411 creator A5036659681 @default.
- W3012087411 creator A5056451010 @default.
- W3012087411 creator A5065267684 @default.
- W3012087411 creator A5079453950 @default.
- W3012087411 creator A5084711809 @default.
- W3012087411 date "2020-03-09" @default.
- W3012087411 modified "2023-10-16" @default.
- W3012087411 title "Transcriptome analysis of HPV-induced warts and healthy skin in humans" @default.
- W3012087411 cites W114913072 @default.
- W3012087411 cites W1492665086 @default.
- W3012087411 cites W1586776409 @default.
- W3012087411 cites W178098991 @default.
- W3012087411 cites W1894267660 @default.
- W3012087411 cites W1965007203 @default.
- W3012087411 cites W1976744907 @default.
- W3012087411 cites W1984960581 @default.
- W3012087411 cites W1986411025 @default.
- W3012087411 cites W1997953790 @default.
- W3012087411 cites W1999517476 @default.
- W3012087411 cites W2045302710 @default.
- W3012087411 cites W2058786551 @default.
- W3012087411 cites W2077996667 @default.
- W3012087411 cites W2080125477 @default.
- W3012087411 cites W2092110793 @default.
- W3012087411 cites W2092118888 @default.
- W3012087411 cites W2101193123 @default.
- W3012087411 cites W2116471128 @default.
- W3012087411 cites W2125207211 @default.
- W3012087411 cites W2141452772 @default.
- W3012087411 cites W2151165759 @default.
- W3012087411 cites W2160384049 @default.
- W3012087411 cites W2167664841 @default.
- W3012087411 cites W2264969613 @default.
- W3012087411 cites W2342213749 @default.
- W3012087411 cites W2406512701 @default.
- W3012087411 cites W2565448904 @default.
- W3012087411 cites W2597447845 @default.
- W3012087411 cites W2598072236 @default.
- W3012087411 cites W2608616136 @default.
- W3012087411 cites W2618829867 @default.
- W3012087411 cites W2742540929 @default.
- W3012087411 cites W2753649550 @default.
- W3012087411 cites W2779623922 @default.
- W3012087411 cites W2789506996 @default.
- W3012087411 cites W2803142374 @default.
- W3012087411 cites W2806962621 @default.
- W3012087411 cites W2898769707 @default.
- W3012087411 cites W2939144109 @default.
- W3012087411 cites W2944746248 @default.
- W3012087411 cites W2952001873 @default.
- W3012087411 cites W849914134 @default.
- W3012087411 doi "https://doi.org/10.1186/s12920-020-0700-7" @default.
- W3012087411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7063766" @default.
- W3012087411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32151264" @default.
- W3012087411 hasPublicationYear "2020" @default.
- W3012087411 type Work @default.
- W3012087411 sameAs 3012087411 @default.
- W3012087411 citedByCount "12" @default.
- W3012087411 countsByYear W30120874112020 @default.
- W3012087411 countsByYear W30120874112021 @default.
- W3012087411 countsByYear W30120874112022 @default.
- W3012087411 countsByYear W30120874112023 @default.
- W3012087411 crossrefType "journal-article" @default.
- W3012087411 hasAuthorship W3012087411A5036659681 @default.
- W3012087411 hasAuthorship W3012087411A5056451010 @default.
- W3012087411 hasAuthorship W3012087411A5065267684 @default.
- W3012087411 hasAuthorship W3012087411A5079453950 @default.
- W3012087411 hasAuthorship W3012087411A5084711809 @default.
- W3012087411 hasBestOaLocation W30120874111 @default.
- W3012087411 hasConcept C104317684 @default.
- W3012087411 hasConcept C121608353 @default.
- W3012087411 hasConcept C136449434 @default.
- W3012087411 hasConcept C150194340 @default.
- W3012087411 hasConcept C159047783 @default.
- W3012087411 hasConcept C162317418 @default.
- W3012087411 hasConcept C190727270 @default.
- W3012087411 hasConcept C203014093 @default.
- W3012087411 hasConcept C2776709828 @default.
- W3012087411 hasConcept C2778220009 @default.
- W3012087411 hasConcept C2778308922 @default.
- W3012087411 hasConcept C2778580637 @default.
- W3012087411 hasConcept C2779138994 @default.
- W3012087411 hasConcept C502942594 @default.
- W3012087411 hasConcept C54355233 @default.
- W3012087411 hasConcept C86803240 @default.
- W3012087411 hasConcept C8891405 @default.
- W3012087411 hasConceptScore W3012087411C104317684 @default.
- W3012087411 hasConceptScore W3012087411C121608353 @default.
- W3012087411 hasConceptScore W3012087411C136449434 @default.
- W3012087411 hasConceptScore W3012087411C150194340 @default.
- W3012087411 hasConceptScore W3012087411C159047783 @default.
- W3012087411 hasConceptScore W3012087411C162317418 @default.
- W3012087411 hasConceptScore W3012087411C190727270 @default.
- W3012087411 hasConceptScore W3012087411C203014093 @default.
- W3012087411 hasConceptScore W3012087411C2776709828 @default.
- W3012087411 hasConceptScore W3012087411C2778220009 @default.
- W3012087411 hasConceptScore W3012087411C2778308922 @default.
- W3012087411 hasConceptScore W3012087411C2778580637 @default.