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- W3012087673 endingPage "1103" @default.
- W3012087673 startingPage "1103" @default.
- W3012087673 abstract "Hematopoietic stem cells (HSCs) are responsible for the production of blood cells throughout the human lifespan. Single HSCs can give rise to at least eight distinct blood-cell lineages. Together, hematopoiesis, erythropoiesis, and angiogenesis coordinate several biological processes, i.e., cellular interactions during development and proliferation, guided migration, lineage programming, and reprogramming by transcription factors. Any dysregulation of these processes can result in hematological disorders and/or malignancies. Several studies of the molecular mechanisms governing HSC maintenance have demonstrated that protein regulation by the ubiquitin proteasomal pathway is crucial for normal HSC function. Recent studies have shown that reversal of ubiquitination by deubiquitinating enzymes (DUBs) plays an equally important role in hematopoiesis; however, information regarding the biological function of DUBs is limited. In this review, we focus on recent discoveries about the physiological roles of DUBs in hematopoiesis, erythropoiesis, and angiogenesis and discuss the DUBs associated with common hematological disorders and malignancies, which are potential therapeutic drug targets." @default.
- W3012087673 created "2020-03-23" @default.
- W3012087673 creator A5004151645 @default.
- W3012087673 creator A5016448895 @default.
- W3012087673 creator A5028047486 @default.
- W3012087673 creator A5068539451 @default.
- W3012087673 creator A5087624704 @default.
- W3012087673 date "2020-04-28" @default.
- W3012087673 modified "2023-10-13" @default.
- W3012087673 title "The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies" @default.
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