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- W3012111617 abstract "Proteolysis targeting chimeras (PROTACs) are heterobifunctional molecules and allow selective protein degradation by addressing the natural ubiquitin proteasome system. As this new strategy of chemically induced protein degradation can serve as a biological tool and provides new possibilities for drug discovery, it has been applied to a variety of targets including (nuclear) receptors, kinases, and epigenetic proteins. A lot of PROTACs have already been designed in the field of epigenetics, and their synthesis and characterization highly contributed to structural optimization and improved mechanistic understanding of these molecules. In this review, we will discuss and summarize recent advances in PROTAC discovery with focus on epigenetic targets." @default.
- W3012111617 created "2020-03-23" @default.
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- W3012111617 date "2020-08-01" @default.
- W3012111617 modified "2023-10-16" @default.
- W3012111617 title "Proteolysis targeting chimeras (PROTACs) for epigenetics research" @default.
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- W3012111617 doi "https://doi.org/10.1016/j.cbpa.2020.01.010" @default.
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