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• W3012113304 abstract "Type I interferon (IFN) drives pathology in systemic lupus erythematosus (SLE) and can be tracked via IFN-inducible transcripts in blood. Here, we examined whether measurement of circulating proteins, which enter the bloodstream from inflamed tissues, also offers insight into global IFN activity. Using a novel protocol we generated 1,132 aptamer-based protein measurements from anti-dsDNApos SLE blood samples and derived an IFN protein signature (IFNPS) that approximates the IFN 21-gene signature (IFNGS). Of 82 patients with SLE, IFNPS was elevated for 89% of IFNGS-high patients (49/55) and 26% of IFNGS-low patients (7/27). IFNGS-high/IFNPS-high patients exhibited activated NK, CD4, and CD8 T cells, while IFNPS-high only patients did not. IFNPS correlated with global disease activity in lymphopenic and non-lymphopenic patients and decreased following type I IFN neutralisation with anifrolumab in the SLE phase IIb study, MUSE. In summary, we developed a protein signature that reflects IFNGS and identifies a new subset of patients with SLE who have IFN activity." @default.
• W3012113304 created "2020-03-23" @default.
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• W3012113304 date "2020-03-10" @default.
• W3012113304 modified "2023-10-14" @default.
• W3012113304 title "Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus" @default.
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• W3012113304 doi "https://doi.org/10.1038/s41598-020-60563-9" @default.
• W3012113304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7064569" @default.
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