FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012132022> ?p ?o ?g. }

• W3012132022 abstract "Cibotium barometz and Vitex pubescens are Malaysian medicinal plants usedtraditionally as remedies for gastrointestinal ailments and wounds. The present studyaimed to assess the gastro protective effects and wound healing potential of both leavesof plants. In vitro, their ethanol extracts showed high antioxidant capacities with nocytotoxic effects on WRL-68 cell line. The active compounds identified were 24-Methylenecycloartanol in C. barometz and Vitexin with Luteoloside in V. pubescens.Down regulation of Bax and up regulation of Col1a2 genes were observed in Hs27fibroblast cells treated with C. barometz. In vivo, neither hepatotoxicity nornephrotoxicity was detected in the acute toxicity test of treated Sprague Dawley (SD)rats with each plant. In a dose-dependent manner, the rats pre-treated with each extractprior to being ethanol induced with gastric ulcers showed significant decreasing of ulcerarea, moderate to mild disruption of the surface epithelium with reduction insubmucosal oedema and leucocyte infiltration in the gastric tissue comparing to ulcercontrol group. Moreover, Periodic acid Schiff (PAS) stain demonstrated an increasing inglycoprotein content of gastric mucus barrier, over expression of Heat Shock Protein 70(HSP70) and down-expression of Bcl-2-associated X protein (Bax) in rats pre-fed witheach plant. Gastric tissue homogenates revealed significant increase of superoxidedismutase activity (SOD) and decrease of malondialdehyde (MDA) levels. In the woundhealing studies, the normal wounds of each rat that dressed with C. barometz and V.pubescens leaves demonstrated a reducing of the wound closure area and acceleration ofthe wound healing potential in a dose independent manner and time of dressing.Moreover, the granulation tissues of wounds stained by hematoxylin and eosin (H&E)displayed the increases of fibroblast proliferations, vascularization, and collagendepositions with fewer inflammatory cells. In addition, Masson‟s trichrome (MT)staining of each dressed rat demonstrated high collagen accumulations and generations ivof new capillary vessels of the endothelial cells in the dressed rats when compared tocarboxymethyl cellulose (CMC 2%) of vehicle group. The protein expressions ofHSP70 was up regulated but Bax was down regulated were down regulated, elevated ofSOD endogenous enzyme activities and dropped of MDA levels of normal skin woundswere exhibited in normal rats compared to the vehicle group.However, the results of diabetic wound had more time to be healed than normalwounds in the rats of experiments as a result of delaying in the chronic diseases. Thediabetic wounds in rats, which dressed with C. barometz and V. pubescens leavesshowed a lower of wound closure area and acceleration of the wound closure percentageof wounds in a dose independent manner and time of healing. Moreover, the granulationtissues of wounds using H&E staining exhibited the increases of fibroblastproliferations, vascularization, and collagen depositions with fewer inflammatory cells.Additionally, MT staining of treated rats demonstrated high collagen accumulations andgenerations of new capillary vessels of the endothelial cells in the dressed rats whencompared to carboxymethyl cellulose (CMC 2%) of vehicle group. Conversely, theprotein expressions of HSP70 was up regulated and Bax was down regulated of the skintissue, elevated of SOD endogenous enzyme activities and dropped of MDA levels ofdiabetic rats were exhibited compared to the vehicle group. Therefore, the acceleratedhealing of wounds and ulcers in this study may be as a result of each plant in this study,which had antioxidant and anti-inflammatory properties particularly, C. barometz." @default.
• W3012132022 created "2020-03-23" @default.
• W3012132022 creator A5054052475 @default.
• W3012132022 creator A5078438391 @default.
• W3012132022 date "2017-01-01" @default.
• W3012132022 modified "2023-09-27" @default.
• W3012132022 title "Evaluation of gastro protective effect and wound healing potential of cibotium barometz and vitex pubecsens in an animal model / Nahla Saeed Ibraheem Alwajeeh" @default.
• W3012132022 hasPublicationYear "2017" @default.
• W3012132022 type Work @default.
• W3012132022 sameAs 3012132022 @default.
• W3012132022 citedByCount "0" @default.
• W3012132022 crossrefType "dissertation" @default.
• W3012132022 hasAuthorship W3012132022A5054052475 @default.
• W3012132022 hasAuthorship W3012132022A5078438391 @default.
• W3012132022 hasConcept C185592680 @default.
• W3012132022 hasConcept C203014093 @default.
• W3012132022 hasConcept C2775838275 @default.
• W3012132022 hasConcept C2778004101 @default.
• W3012132022 hasConcept C2778401633 @default.
• W3012132022 hasConcept C2780269544 @default.
• W3012132022 hasConcept C55493867 @default.
• W3012132022 hasConcept C556039675 @default.
• W3012132022 hasConcept C71924100 @default.
• W3012132022 hasConcept C98274493 @default.
• W3012132022 hasConceptScore W3012132022C185592680 @default.
• W3012132022 hasConceptScore W3012132022C203014093 @default.
• W3012132022 hasConceptScore W3012132022C2775838275 @default.
• W3012132022 hasConceptScore W3012132022C2778004101 @default.
• W3012132022 hasConceptScore W3012132022C2778401633 @default.
• W3012132022 hasConceptScore W3012132022C2780269544 @default.
• W3012132022 hasConceptScore W3012132022C55493867 @default.
• W3012132022 hasConceptScore W3012132022C556039675 @default.
• W3012132022 hasConceptScore W3012132022C71924100 @default.
• W3012132022 hasConceptScore W3012132022C98274493 @default.
• W3012132022 hasLocation W30121320221 @default.
• W3012132022 hasOpenAccess W3012132022 @default.
• W3012132022 hasPrimaryLocation W30121320221 @default.
• W3012132022 hasRelatedWork W1836625536 @default.
• W3012132022 hasRelatedWork W2016582451 @default.
• W3012132022 hasRelatedWork W2039096560 @default.
• W3012132022 hasRelatedWork W2059929189 @default.
• W3012132022 hasRelatedWork W2098324605 @default.
• W3012132022 hasRelatedWork W2140463924 @default.
• W3012132022 hasRelatedWork W2195434535 @default.
• W3012132022 hasRelatedWork W2315492552 @default.
• W3012132022 hasRelatedWork W2346623581 @default.
• W3012132022 hasRelatedWork W2350859482 @default.
• W3012132022 hasRelatedWork W2356511775 @default.
• W3012132022 hasRelatedWork W2366819877 @default.
• W3012132022 hasRelatedWork W2367024929 @default.
• W3012132022 hasRelatedWork W2386391599 @default.
• W3012132022 hasRelatedWork W2387920080 @default.
• W3012132022 hasRelatedWork W2411702228 @default.
• W3012132022 hasRelatedWork W2915495830 @default.
• W3012132022 hasRelatedWork W2991592819 @default.
• W3012132022 hasRelatedWork W3088554216 @default.
• W3012132022 hasRelatedWork W3118676948 @default.
• W3012132022 isParatext "false" @default.
• W3012132022 isRetracted "false" @default.
• W3012132022 magId "3012132022" @default.
• W3012132022 workType "dissertation" @default.