FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012132912> ?p ?o ?g. }

• W3012132912 endingPage "122391" @default.
• W3012132912 startingPage "122391" @default.
• W3012132912 abstract "The development of biocompatible polylactide (PLA)-based block copolymers for constructing self-assembled nanoaggregates degradable in response to endogenous stimuli found in cell environments is promising for enhanced/controlled drug delivery in pharmaceutical science. Despite advances in the synthesis of various PLA-based nanoassemblies featured with only a single stimulus response, the design and development of advanced nanoassemblies integrated with two endogenous stimuli-responsive cleavable linkages for dual stimuli response is challenging. Here we report an approach to the synthesis of a new PLA-based diblock copolymer having dual reduction-cleavable disulfide and acid-labile acetal linkages at the block junction. Key to the approach is the use of a double-head initiator designed uniquely with both acetal and disulfide linkages as well as with both OH and bromine terminal groups. Our comprehensive results from structural analysis and degradation through chemical transition suggest the requirement of a rational combination of controlled polymerization techniques and facile coupling reactions for the synthesis of well-controlled PLA-based diblock copolymer having both disulfide and acetal linkages. The main reason is attributed to the instability of acetal linkages under ROP condition with a tin catalyst at an elevated temperature. The resultant copolymer self-assembles to form shell-sheddable nanoassemblies that are disintegrated in response to dual acid/reduction. This work demonstrates the importance in the development of efficient polymerization strategies by utilizing well-established polymerization techniques to synthesize novel functional copolymers with complicated architectures and various functionalities sensitive to reaction environments." @default.
• W3012132912 created "2020-03-23" @default.
• W3012132912 creator A5002536493 @default.
• W3012132912 creator A5015727324 @default.
• W3012132912 creator A5035301452 @default.
• W3012132912 creator A5066185032 @default.
• W3012132912 date "2020-04-01" @default.
• W3012132912 modified "2023-10-18" @default.
• W3012132912 title "Synthesis of degradable PLA-based diblock copolymers with dual acid/reduction-cleavable junction" @default.
• W3012132912 cites W1968374211 @default.
• W3012132912 cites W1971049870 @default.
• W3012132912 cites W1971948817 @default.
• W3012132912 cites W1981551537 @default.
• W3012132912 cites W1985570466 @default.
• W3012132912 cites W2009419411 @default.
• W3012132912 cites W2010818819 @default.
• W3012132912 cites W2014322240 @default.
• W3012132912 cites W2025900229 @default.
• W3012132912 cites W2026260644 @default.
• W3012132912 cites W2029255146 @default.
• W3012132912 cites W2042565735 @default.
• W3012132912 cites W2049622924 @default.
• W3012132912 cites W2050404581 @default.
• W3012132912 cites W2051639211 @default.
• W3012132912 cites W2055991021 @default.
• W3012132912 cites W2071447376 @default.
• W3012132912 cites W2077952511 @default.
• W3012132912 cites W2078114388 @default.
• W3012132912 cites W2078502872 @default.
• W3012132912 cites W2083256312 @default.
• W3012132912 cites W2094100731 @default.
• W3012132912 cites W2124791532 @default.
• W3012132912 cites W2130166533 @default.
• W3012132912 cites W2150647921 @default.
• W3012132912 cites W2151349551 @default.
• W3012132912 cites W2156373744 @default.
• W3012132912 cites W2158431756 @default.
• W3012132912 cites W2158927085 @default.
• W3012132912 cites W2163887121 @default.
• W3012132912 cites W2209405800 @default.
• W3012132912 cites W2295935487 @default.
• W3012132912 cites W2312997016 @default.
• W3012132912 cites W2314616617 @default.
• W3012132912 cites W2325737725 @default.
• W3012132912 cites W2327227196 @default.
• W3012132912 cites W2328653773 @default.
• W3012132912 cites W2335526829 @default.
• W3012132912 cites W2399080566 @default.
• W3012132912 cites W2465724398 @default.
• W3012132912 cites W2488409378 @default.
• W3012132912 cites W2612385917 @default.
• W3012132912 cites W2742715679 @default.
• W3012132912 cites W2797818220 @default.
• W3012132912 cites W2810042218 @default.
• W3012132912 cites W2885666891 @default.
• W3012132912 cites W2895365712 @default.
• W3012132912 cites W4240749418 @default.
• W3012132912 doi "https://doi.org/10.1016/j.polymer.2020.122391" @default.
• W3012132912 hasPublicationYear "2020" @default.
• W3012132912 type Work @default.
• W3012132912 sameAs 3012132912 @default.
• W3012132912 citedByCount "9" @default.
• W3012132912 countsByYear W30121329122020 @default.
• W3012132912 countsByYear W30121329122021 @default.
• W3012132912 countsByYear W30121329122023 @default.
• W3012132912 crossrefType "journal-article" @default.
• W3012132912 hasAuthorship W3012132912A5002536493 @default.
• W3012132912 hasAuthorship W3012132912A5015727324 @default.
• W3012132912 hasAuthorship W3012132912A5035301452 @default.
• W3012132912 hasAuthorship W3012132912A5066185032 @default.
• W3012132912 hasConcept C15920480 @default.
• W3012132912 hasConcept C171250308 @default.
• W3012132912 hasConcept C178790620 @default.
• W3012132912 hasConcept C185592680 @default.
• W3012132912 hasConcept C188027245 @default.
• W3012132912 hasConcept C192562407 @default.
• W3012132912 hasConcept C21951064 @default.
• W3012132912 hasConcept C27256138 @default.
• W3012132912 hasConcept C2777731525 @default.
• W3012132912 hasConcept C44228677 @default.
• W3012132912 hasConcept C521977710 @default.
• W3012132912 hasConcept C53105671 @default.
• W3012132912 hasConcept C55493867 @default.
• W3012132912 hasConceptScore W3012132912C15920480 @default.
• W3012132912 hasConceptScore W3012132912C171250308 @default.
• W3012132912 hasConceptScore W3012132912C178790620 @default.
• W3012132912 hasConceptScore W3012132912C185592680 @default.
• W3012132912 hasConceptScore W3012132912C188027245 @default.
• W3012132912 hasConceptScore W3012132912C192562407 @default.
• W3012132912 hasConceptScore W3012132912C21951064 @default.
• W3012132912 hasConceptScore W3012132912C27256138 @default.
• W3012132912 hasConceptScore W3012132912C2777731525 @default.
• W3012132912 hasConceptScore W3012132912C44228677 @default.
• W3012132912 hasConceptScore W3012132912C521977710 @default.
• W3012132912 hasConceptScore W3012132912C53105671 @default.
• W3012132912 hasConceptScore W3012132912C55493867 @default.
• W3012132912 hasFunder F4320320994 @default.
• W3012132912 hasFunder F4320334593 @default.

• next