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• W3012142761 abstract "Ewing sarcoma (EwS) is an aggressive cancer displaying an undifferentiated small-round-cell histomorphology that can be easily confused with a broad spectrum of differential diagnoses. Using comparative transcriptomics and immunohistochemistry (IHC), we previously identified BCL11B and GLG1 as potential specific auxiliary IHC markers for EWSR1-FLI1-positive EwS. Herein, we aimed at validating the specificity of both markers in a far larger and independent cohort of EwS (including EWSR1-ERG-positive cases) and differential diagnoses. Furthermore, we evaluated their intra-tumoral expression heterogeneity. Thus, we stained tissue microarrays from 133 molecularly confirmed EwS cases and 320 samples from morphological mimics, as well as a series of patient-derived xenograft (PDX) models for BCL11B, GLG1, and CD99, and systematically assessed the immunoreactivity and optimal cut-offs for each marker. These analyses demonstrated that high BCL11B and/or GLG1 immunoreactivity in CD99-positive cases had a specificity of 97.5% and an accuracy of 87.4% for diagnosing EwS solely by IHC, and that the markers were expressed by EWSR1-ERG-positive EwS. Only little intra-tumoral heterogeneity in immunoreactivity was observed for differential diagnoses. These results indicate that BCL11B and GLG1 may help as specific auxiliary IHC markers in diagnosing EwS in conjunction with CD99, especially if confirmatory molecular diagnostics are not available." @default.
• W3012142761 created "2020-03-23" @default.
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• W3012142761 date "2020-03-10" @default.
• W3012142761 modified "2023-10-09" @default.
• W3012142761 title "High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma" @default.
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• W3012142761 cites W1975832045 @default.
• W3012142761 cites W1993735828 @default.
• W3012142761 cites W1994568630 @default.
• W3012142761 cites W2000920155 @default.
• W3012142761 cites W2002978824 @default.
• W3012142761 cites W2016043228 @default.
• W3012142761 cites W2023693173 @default.
• W3012142761 cites W2027899965 @default.
• W3012142761 cites W2029525645 @default.
• W3012142761 cites W2032222958 @default.
• W3012142761 cites W2035636897 @default.
• W3012142761 cites W2035723470 @default.
• W3012142761 cites W2040351091 @default.
• W3012142761 cites W2041549448 @default.
• W3012142761 cites W2044474496 @default.
• W3012142761 cites W2050486500 @default.
• W3012142761 cites W2056612230 @default.
• W3012142761 cites W2066280610 @default.
• W3012142761 cites W2069351898 @default.
• W3012142761 cites W2076107852 @default.
• W3012142761 cites W2078954603 @default.
• W3012142761 cites W2083685172 @default.
• W3012142761 cites W2095605091 @default.
• W3012142761 cites W2101854267 @default.
• W3012142761 cites W2124328974 @default.
• W3012142761 cites W2127507099 @default.
• W3012142761 cites W2128628566 @default.
• W3012142761 cites W2137828506 @default.
• W3012142761 cites W2164559547 @default.
• W3012142761 cites W2174575512 @default.
• W3012142761 cites W2198646997 @default.
• W3012142761 cites W2253637172 @default.
• W3012142761 cites W2340386540 @default.
• W3012142761 cites W2516135447 @default.
• W3012142761 cites W2531471568 @default.
• W3012142761 cites W2572282612 @default.
• W3012142761 cites W2584748820 @default.
• W3012142761 cites W2671119825 @default.
• W3012142761 cites W2684055462 @default.
• W3012142761 cites W2750663875 @default.
• W3012142761 cites W2757075748 @default.
• W3012142761 cites W2769110289 @default.
• W3012142761 cites W2775681294 @default.
• W3012142761 cites W2790354099 @default.
• W3012142761 cites W2793833695 @default.
• W3012142761 cites W2807735886 @default.
• W3012142761 cites W2808998977 @default.
• W3012142761 cites W2886123855 @default.
• W3012142761 cites W2888158086 @default.
• W3012142761 cites W2891557623 @default.
• W3012142761 cites W2903502770 @default.
• W3012142761 cites W2903502777 @default.
• W3012142761 cites W2903530594 @default.
• W3012142761 cites W2912122694 @default.
• W3012142761 cites W2920030348 @default.
• W3012142761 cites W2922989235 @default.
• W3012142761 cites W2950426772 @default.
• W3012142761 cites W2951579145 @default.
• W3012142761 cites W2954036960 @default.
• W3012142761 cites W2966301722 @default.
• W3012142761 cites W2972522611 @default.
• W3012142761 cites W2977223621 @default.
• W3012142761 cites W2977920052 @default.
• W3012142761 cites W2992193737 @default.

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