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- W3012169683 endingPage "1881" @default.
- W3012169683 startingPage "1881" @default.
- W3012169683 abstract "Flavodoxins are small soluble electron transfer proteins widely present in bacteria and absent in vertebrates. Flavodoxins participate in different metabolic pathways and, in some bacteria, they have been shown to be essential proteins representing promising therapeutic targets to fight bacterial infections. Using purified flavodoxin and chemical libraries, leads can be identified that block flavodoxin function and act as bactericidal molecules, as it has been demonstrated for Helicobacter pylori (Hp), the most prevalent human gastric pathogen. Increasing antimicrobial resistance by this bacterium has led current therapies to lose effectiveness, so alternative treatments are urgently required. Here, we summarize, with a focus on flavodoxin, opportunities for pharmacological intervention offered by the potential protein targets described for this bacterium and provide information on other gastrointestinal pathogens and also on bacteria from the gut microbiota that contain flavodoxin. The process of discovery and development of novel antimicrobials specific for Hp flavodoxin that is being carried out in our group is explained, as it can be extrapolated to the discovery of inhibitors specific for other gastric pathogens. The high specificity for Hp of the antimicrobials developed may be of help to reduce damage to the gut microbiota and to slow down the development of resistant Hp mutants." @default.
- W3012169683 created "2020-03-23" @default.
- W3012169683 creator A5041028769 @default.
- W3012169683 creator A5045648793 @default.
- W3012169683 date "2020-03-10" @default.
- W3012169683 modified "2023-10-05" @default.
- W3012169683 title "Flavodoxins as Novel Therapeutic Targets against Helicobacter pylori and Other Gastric Pathogens" @default.
- W3012169683 cites W1187390301 @default.
- W3012169683 cites W1490463394 @default.
- W3012169683 cites W1606239426 @default.
- W3012169683 cites W1781298275 @default.
- W3012169683 cites W1783811381 @default.
- W3012169683 cites W1822840505 @default.
- W3012169683 cites W1950687899 @default.
- W3012169683 cites W1964724015 @default.
- W3012169683 cites W1967539008 @default.
- W3012169683 cites W1967576852 @default.
- W3012169683 cites W1972473915 @default.
- W3012169683 cites W1972480564 @default.
- W3012169683 cites W1972652079 @default.
- W3012169683 cites W1975094488 @default.
- W3012169683 cites W1975705452 @default.
- W3012169683 cites W1977858129 @default.
- W3012169683 cites W1980910332 @default.
- W3012169683 cites W1981739759 @default.
- W3012169683 cites W1982356218 @default.
- W3012169683 cites W1984346165 @default.
- W3012169683 cites W1986491135 @default.
- W3012169683 cites W1988373835 @default.
- W3012169683 cites W1988583799 @default.
- W3012169683 cites W1991463882 @default.
- W3012169683 cites W1995659918 @default.
- W3012169683 cites W1996274990 @default.
- W3012169683 cites W1998165486 @default.
- W3012169683 cites W1998630067 @default.
- W3012169683 cites W2001138478 @default.
- W3012169683 cites W2001792721 @default.
- W3012169683 cites W2002030730 @default.
- W3012169683 cites W2002341456 @default.
- W3012169683 cites W2002458103 @default.
- W3012169683 cites W2002681176 @default.
- W3012169683 cites W2004080824 @default.
- W3012169683 cites W2005604534 @default.
- W3012169683 cites W2011741429 @default.
- W3012169683 cites W2012227564 @default.
- W3012169683 cites W2012503707 @default.
- W3012169683 cites W2014179305 @default.
- W3012169683 cites W2014651956 @default.
- W3012169683 cites W2014668832 @default.
- W3012169683 cites W2015490227 @default.
- W3012169683 cites W2015820526 @default.
- W3012169683 cites W2016662821 @default.
- W3012169683 cites W2016993760 @default.
- W3012169683 cites W2017938149 @default.
- W3012169683 cites W2018279960 @default.
- W3012169683 cites W2018620177 @default.
- W3012169683 cites W2019453765 @default.
- W3012169683 cites W2021653373 @default.
- W3012169683 cites W2022995312 @default.
- W3012169683 cites W2027544298 @default.
- W3012169683 cites W2029083716 @default.
- W3012169683 cites W2029837781 @default.
- W3012169683 cites W2034637907 @default.
- W3012169683 cites W2036408983 @default.
- W3012169683 cites W2038251575 @default.
- W3012169683 cites W2041852369 @default.
- W3012169683 cites W2046500978 @default.
- W3012169683 cites W2050675256 @default.
- W3012169683 cites W2052498400 @default.
- W3012169683 cites W2052621420 @default.
- W3012169683 cites W2053131514 @default.
- W3012169683 cites W2055382051 @default.
- W3012169683 cites W2056079664 @default.
- W3012169683 cites W2056392930 @default.
- W3012169683 cites W2058873907 @default.
- W3012169683 cites W2061350171 @default.
- W3012169683 cites W2063199331 @default.
- W3012169683 cites W2065509771 @default.
- W3012169683 cites W2065624359 @default.
- W3012169683 cites W2071623230 @default.
- W3012169683 cites W2078944494 @default.
- W3012169683 cites W2080933675 @default.
- W3012169683 cites W2081419858 @default.
- W3012169683 cites W2081776839 @default.
- W3012169683 cites W2085460757 @default.
- W3012169683 cites W2085693392 @default.
- W3012169683 cites W2088744527 @default.
- W3012169683 cites W2091255662 @default.
- W3012169683 cites W2093196686 @default.
- W3012169683 cites W2097301400 @default.
- W3012169683 cites W2098668525 @default.
- W3012169683 cites W2104237240 @default.
- W3012169683 cites W2108067237 @default.
- W3012169683 cites W2110769880 @default.
- W3012169683 cites W2112215083 @default.
- W3012169683 cites W2113140044 @default.
- W3012169683 cites W2113271899 @default.
- W3012169683 cites W2114763294 @default.