Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012171055> ?p ?o ?g. }
- W3012171055 endingPage "100617" @default.
- W3012171055 startingPage "100617" @default.
- W3012171055 abstract "Circulating tumor cell (CTC) detection has become a powerful tool for early diagnosis of metastasis and precise monitoring of cancer progression. While existing microchips have achieved promising progress on CTC capture, facile release and in situ regulation of CTC from devices for downstream analysis have rarely been realized. Herein, we demonstrated a porous nanoflower substrate (PNFS)-embedded microfluidic device that integrated multiple functionalities of effective CTC capture, in situ intracellular delivery, and nondestructive CTC release on a single device. The core of the device, PNFS, consisting of hierarchical Zn-phosphate composite structure on a nanoporous membrane, was produced by converting from micro/nano-fabricated ZnO nanostraws by low-temperature hydrothermal method and could be degraded via sodium citrate solution treatment for 20 min. Cancer cells could be captured on the PNFS with high efficiency up to 93.9 ± 1.7% after specific antibody conjugations, and be non-destructively released from the PNFS by using biocompatible sodium citrate to rapidly dissolve the PNFS at room temperature. In addition, the degradable PNFS was integrated with a microfluidic electroporation device, allowing in situ intracellular molecular delivery into the captured cells for cell modifications, where such reengineered cells could be further released for subsequent applications. This device promises to be a versatile and efficient platform for CTC analysis, with great potential for the futuristic cell-based cancer diagnostics and therapies." @default.
- W3012171055 created "2020-03-23" @default.
- W3012171055 creator A5003323399 @default.
- W3012171055 creator A5003986323 @default.
- W3012171055 creator A5006166258 @default.
- W3012171055 creator A5020848795 @default.
- W3012171055 creator A5029516192 @default.
- W3012171055 creator A5030670609 @default.
- W3012171055 creator A5035424523 @default.
- W3012171055 creator A5036655258 @default.
- W3012171055 creator A5059272312 @default.
- W3012171055 creator A5075180997 @default.
- W3012171055 creator A5078619996 @default.
- W3012171055 creator A5083843207 @default.
- W3012171055 creator A5087261074 @default.
- W3012171055 creator A5090597551 @default.
- W3012171055 date "2020-06-01" @default.
- W3012171055 modified "2023-09-30" @default.
- W3012171055 title "Degradable porous nanoflower substrate-embedded microfluidic device for capture, release and in situ manipulation of cancer cells" @default.
- W3012171055 cites W1506680628 @default.
- W3012171055 cites W1930822899 @default.
- W3012171055 cites W1938655770 @default.
- W3012171055 cites W1948718388 @default.
- W3012171055 cites W1966984015 @default.
- W3012171055 cites W1972782334 @default.
- W3012171055 cites W2004280628 @default.
- W3012171055 cites W2009158376 @default.
- W3012171055 cites W2011516055 @default.
- W3012171055 cites W2050547995 @default.
- W3012171055 cites W2051747360 @default.
- W3012171055 cites W2056952640 @default.
- W3012171055 cites W2057306577 @default.
- W3012171055 cites W2078483179 @default.
- W3012171055 cites W2079673499 @default.
- W3012171055 cites W2086613330 @default.
- W3012171055 cites W2090652594 @default.
- W3012171055 cites W2091102810 @default.
- W3012171055 cites W2095554214 @default.
- W3012171055 cites W2095726486 @default.
- W3012171055 cites W2097126143 @default.
- W3012171055 cites W2116558338 @default.
- W3012171055 cites W2124999157 @default.
- W3012171055 cites W2129496393 @default.
- W3012171055 cites W2129594984 @default.
- W3012171055 cites W2140497649 @default.
- W3012171055 cites W2143490853 @default.
- W3012171055 cites W2149414866 @default.
- W3012171055 cites W2156838522 @default.
- W3012171055 cites W2157807617 @default.
- W3012171055 cites W2161661776 @default.
- W3012171055 cites W2166535928 @default.
- W3012171055 cites W2230793918 @default.
- W3012171055 cites W2237441939 @default.
- W3012171055 cites W2279875505 @default.
- W3012171055 cites W2315687126 @default.
- W3012171055 cites W2321913191 @default.
- W3012171055 cites W2327928206 @default.
- W3012171055 cites W2343629045 @default.
- W3012171055 cites W2414095963 @default.
- W3012171055 cites W2430771036 @default.
- W3012171055 cites W2460125764 @default.
- W3012171055 cites W2463345577 @default.
- W3012171055 cites W2469841052 @default.
- W3012171055 cites W2475715991 @default.
- W3012171055 cites W2522873012 @default.
- W3012171055 cites W2531550383 @default.
- W3012171055 cites W2591854908 @default.
- W3012171055 cites W2611774476 @default.
- W3012171055 cites W2729760051 @default.
- W3012171055 cites W2754394285 @default.
- W3012171055 cites W2755584704 @default.
- W3012171055 cites W2767080030 @default.
- W3012171055 cites W2791477818 @default.
- W3012171055 cites W2802603984 @default.
- W3012171055 cites W2804824927 @default.
- W3012171055 cites W2805343808 @default.
- W3012171055 cites W2898726853 @default.
- W3012171055 cites W2913909915 @default.
- W3012171055 cites W566331622 @default.
- W3012171055 doi "https://doi.org/10.1016/j.apmt.2020.100617" @default.
- W3012171055 hasPublicationYear "2020" @default.
- W3012171055 type Work @default.
- W3012171055 sameAs 3012171055 @default.
- W3012171055 citedByCount "7" @default.
- W3012171055 countsByYear W30121710552021 @default.
- W3012171055 countsByYear W30121710552022 @default.
- W3012171055 crossrefType "journal-article" @default.
- W3012171055 hasAuthorship W3012171055A5003323399 @default.
- W3012171055 hasAuthorship W3012171055A5003986323 @default.
- W3012171055 hasAuthorship W3012171055A5006166258 @default.
- W3012171055 hasAuthorship W3012171055A5020848795 @default.
- W3012171055 hasAuthorship W3012171055A5029516192 @default.
- W3012171055 hasAuthorship W3012171055A5030670609 @default.
- W3012171055 hasAuthorship W3012171055A5035424523 @default.
- W3012171055 hasAuthorship W3012171055A5036655258 @default.
- W3012171055 hasAuthorship W3012171055A5059272312 @default.
- W3012171055 hasAuthorship W3012171055A5075180997 @default.
- W3012171055 hasAuthorship W3012171055A5078619996 @default.