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- W3012183683 abstract "Brincidofovir (BCV) is a lipid conjugate of cidofovir with good oral bioavailability, enabling optimal intracellular levels of the active drug. Lower rates of nephrotoxicity and myelotoxicity make it a favorable alternative. Despite a greater safety profile among pediatric hematopoietic cell transplant recipients, the oral formulation has been associated with increased gastrointestinal toxicity in adult hematopoietic cell transplant recipients. Oral BCV continues to be developed as a countermeasure against smallpox, while a potentially safer intravenous preparation has been out licensed to another company. BCV has demonstrated great in vitro potency against double-stranded DNA viruses, especially adenovirus. Because of its importance for immunocompromised patients, this review aims to evaluate BCV’s clinical and safety profile to support its continued development." @default.
- W3012183683 created "2020-03-23" @default.
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- W3012183683 date "2020-04-01" @default.
- W3012183683 modified "2023-10-06" @default.
- W3012183683 title "Brincidofovir: understanding its unique profile and potential role against adenovirus and other viral infections" @default.
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- W3012183683 doi "https://doi.org/10.2217/fmb-2019-0288" @default.
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