FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012187406> ?p ?o ?g. }

• W3012187406 abstract "Abstract Background Approximately 7% of the general population is affected by an orphan disease, which, in the United States, is defined as affecting fewer than 1 in 1500 people. Disease awareness is often low and time-to-diagnosis delayed. Different legislations worldwide have created incentives for pharmaceutical companies to develop drugs for orphan diseases. A journalistic article in Bloomberg Businessweek has claimed that pharmaceutical companies have tried marketing orphan drugs by placing a specific disease into the popular television series “House, M.D.” which features diagnostic journeys and was produced between 2004 and 2012. This study aimed to describe the presentation of orphan diseases in the television series “House, M.D.”, to test in an exploratory fashion the hypothesis that treatable orphan conditions are overrepresented in “House, M.D.” and to discuss whether such marketing practices may or may not be ethical. Methods A list of all medical cases depicted in the television series “House, M.D.” was obtained and classified as orphan or non-orphan according to the Orphanet database. The ratios of orphan diseases among all diseases, such with an orphan drug designation and such with an orphan drug approval by the FDA were then compared with conservative approximations of real world conditions (chi-squared tests for equality of proportions). STROBE criteria were respected. Results Out of a total of n = 181 different medical diagnoses, n = 42 (23.2%) were orphan diseases. The difference in percentages in between “House, M.D.” and reality was not statistically significant for orphan diseases overall ( p = 0.96), yet was statistically significantly higher for both orphan diseases with one or more orphan drug designations ( p = 0.0192) and such with one or more approved orphan drugs ( p < 0.0001). Conclusions Orphan diseases with a designated and/or approved orphan drug were overrepresented in the television series “House, M.D.” with statistical significance while orphan diseases overall were not. This may be explained by (so far) undocumented efforts of pharmaceutical companies to place their orphan drugs in the television series, as described in the article in Bloomberg Businessweek . Further research is needed into marketing practices in popular and emerging media formats." @default.
• W3012187406 created "2020-03-23" @default.
• W3012187406 creator A5020059403 @default.
• W3012187406 creator A5063686299 @default.
• W3012187406 creator A5088630681 @default.
• W3012187406 creator A5088961810 @default.
• W3012187406 date "2020-03-14" @default.
• W3012187406 modified "2023-10-14" @default.
• W3012187406 title "Disease awareness or subtle product placement? Orphan diseases featured in the television series “House, M.D.” - a cross-sectional analysis" @default.
• W3012187406 cites W1524090626 @default.
• W3012187406 cites W1967601852 @default.
• W3012187406 cites W1983965561 @default.
• W3012187406 cites W1993449179 @default.
• W3012187406 cites W2023316714 @default.
• W3012187406 cites W2023560805 @default.
• W3012187406 cites W2024559544 @default.
• W3012187406 cites W2029856533 @default.
• W3012187406 cites W2032012623 @default.
• W3012187406 cites W2036132972 @default.
• W3012187406 cites W2054519060 @default.
• W3012187406 cites W2076233096 @default.
• W3012187406 cites W2077204318 @default.
• W3012187406 cites W2097649441 @default.
• W3012187406 cites W2124394936 @default.
• W3012187406 cites W2127288833 @default.
• W3012187406 cites W2158041351 @default.
• W3012187406 cites W2170953626 @default.
• W3012187406 cites W2176727293 @default.
• W3012187406 cites W2327981172 @default.
• W3012187406 cites W2514847774 @default.
• W3012187406 cites W2583412497 @default.
• W3012187406 cites W2587479628 @default.
• W3012187406 cites W2593956993 @default.
• W3012187406 cites W2601714407 @default.
• W3012187406 cites W2604575726 @default.
• W3012187406 cites W2766630024 @default.
• W3012187406 cites W2768913262 @default.
• W3012187406 cites W2789570598 @default.
• W3012187406 cites W2792935497 @default.
• W3012187406 cites W2799553549 @default.
• W3012187406 cites W2884486468 @default.
• W3012187406 cites W53878644 @default.
• W3012187406 doi "https://doi.org/10.1186/s12910-020-0463-x" @default.
• W3012187406 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7071776" @default.
• W3012187406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32171294" @default.
• W3012187406 hasPublicationYear "2020" @default.
• W3012187406 type Work @default.
• W3012187406 sameAs 3012187406 @default.
• W3012187406 citedByCount "3" @default.
• W3012187406 countsByYear W30121874062020 @default.
• W3012187406 countsByYear W30121874062021 @default.
• W3012187406 countsByYear W30121874062022 @default.
• W3012187406 crossrefType "journal-article" @default.
• W3012187406 hasAuthorship W3012187406A5020059403 @default.
• W3012187406 hasAuthorship W3012187406A5063686299 @default.
• W3012187406 hasAuthorship W3012187406A5088630681 @default.
• W3012187406 hasAuthorship W3012187406A5088961810 @default.
• W3012187406 hasBestOaLocation W30121874061 @default.
• W3012187406 hasConcept C112698675 @default.
• W3012187406 hasConcept C121242521 @default.
• W3012187406 hasConcept C141071460 @default.
• W3012187406 hasConcept C142724271 @default.
• W3012187406 hasConcept C144133560 @default.
• W3012187406 hasConcept C162324750 @default.
• W3012187406 hasConcept C175444787 @default.
• W3012187406 hasConcept C204787440 @default.
• W3012187406 hasConcept C2777601897 @default.
• W3012187406 hasConcept C2779134260 @default.
• W3012187406 hasConcept C2908647359 @default.
• W3012187406 hasConcept C29122968 @default.
• W3012187406 hasConcept C512399662 @default.
• W3012187406 hasConcept C60644358 @default.
• W3012187406 hasConcept C71924100 @default.
• W3012187406 hasConcept C75480439 @default.
• W3012187406 hasConcept C86803240 @default.
• W3012187406 hasConcept C99454951 @default.
• W3012187406 hasConceptScore W3012187406C112698675 @default.
• W3012187406 hasConceptScore W3012187406C121242521 @default.
• W3012187406 hasConceptScore W3012187406C141071460 @default.
• W3012187406 hasConceptScore W3012187406C142724271 @default.
• W3012187406 hasConceptScore W3012187406C144133560 @default.
• W3012187406 hasConceptScore W3012187406C162324750 @default.
• W3012187406 hasConceptScore W3012187406C175444787 @default.
• W3012187406 hasConceptScore W3012187406C204787440 @default.
• W3012187406 hasConceptScore W3012187406C2777601897 @default.
• W3012187406 hasConceptScore W3012187406C2779134260 @default.
• W3012187406 hasConceptScore W3012187406C2908647359 @default.
• W3012187406 hasConceptScore W3012187406C29122968 @default.
• W3012187406 hasConceptScore W3012187406C512399662 @default.
• W3012187406 hasConceptScore W3012187406C60644358 @default.
• W3012187406 hasConceptScore W3012187406C71924100 @default.
• W3012187406 hasConceptScore W3012187406C75480439 @default.
• W3012187406 hasConceptScore W3012187406C86803240 @default.
• W3012187406 hasConceptScore W3012187406C99454951 @default.
• W3012187406 hasIssue "1" @default.
• W3012187406 hasLocation W30121874061 @default.
• W3012187406 hasLocation W30121874062 @default.
• W3012187406 hasLocation W30121874063 @default.
• W3012187406 hasOpenAccess W3012187406 @default.
• W3012187406 hasPrimaryLocation W30121874061 @default.

• next