FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012194080> ?p ?o ?g. }

• W3012194080 endingPage "3069" @default.
• W3012194080 startingPage "3057" @default.
• W3012194080 abstract "Abstract Background Alpha‐fetoprotein (AFP), routinely used for diagnosis of hepatocellular carcinoma (HCC), is limited with relatively low sensitivity and high false positivity in HBV‐related HCC (HBV‐HCC). Thus, an alternative approach was explored to improve specificity/sensitivity for diagnosis of HBV‐HCC, using the combination of AFP, inflammatory score, and liver function. Methods Chronic hepatitis B (CHB) (n = 510) and HBV‐HCC (n = 473) patients were identified retrospectively for this study. The diagnostic value of single vs combined biomarkers for HBV‐HCC was analyzed, using ROC curve. Results It was observed that elderliness, male sex, cirrhosis, HBeAg + or no‐antiviral therapy, and elevation of ALT, AST, neutrophil‐lymphocyte ratio (NLR), and AFP were associated with developing HBV‐HCC. However, the cut‐off ALT defined by Chinese standard, but not by AASLD, was a risk factor. Interestingly, AFP of HBeAg ‐ HBV‐HCC patients without cirrhosis was significantly higher than that of the HBeAg + patients. AUC values for AFP, ALT, AST, or NLR were 0.84 (95% CI: 0.815 ‐ 0.862), 0.533 (95% CI: 0.501 ‐ 0.565), 0.696 (95% CI: 0.666 ‐ 0.725), or 0.684 (95% CI: 0.654 ‐ 0.713) with optimal cut‐off at 7.21 ng/mL, 43 IU/mL, 38 IU/mL, or 2.61, respectively. Combination of AFP with ALT, AST, and NLR improved the diagnostic performance for HBV‐HCC, compared to any of the single biomarkers or any other combinations among these patients (except no‐cirrhosis). Conclusions Elderliness, male sex, elevated ALT, AST, NLR, AFP, cirrhosis, HBeAg + , and no‐antiviral treatment were independent risk factors for HBV‐HCC. AASLD standard of ALT cut‐off value may not be suitable for the Chinese population. Regular monitoring of HCC among HBeAg ‐ patients with abnormal AFP may improve the management of HBV‐HCC. The diagnostic performance of AFP combined with ALT, AST, and NLR for HBV‐HCC was superior to single biomarker or any other combinations among these patients, and its diagnostic equation can be used as useful tool for differentiation of HBV‐HCC from CHB." @default.
• W3012194080 created "2020-03-23" @default.
• W3012194080 creator A5002747282 @default.
• W3012194080 creator A5003223330 @default.
• W3012194080 creator A5004514476 @default.
• W3012194080 creator A5030330273 @default.
• W3012194080 creator A5040194968 @default.
• W3012194080 creator A5042069878 @default.
• W3012194080 creator A5045138416 @default.
• W3012194080 creator A5063064112 @default.
• W3012194080 creator A5072697895 @default.
• W3012194080 creator A5084445748 @default.
• W3012194080 creator A5086690723 @default.
• W3012194080 creator A5090474210 @default.
• W3012194080 date "2020-03-09" @default.
• W3012194080 modified "2023-10-15" @default.
• W3012194080 title "Combination of inflammatory score/liver function and AFP improves the diagnostic accuracy of HBV‐related hepatocellular carcinoma" @default.
• W3012194080 cites W1521019257 @default.
• W3012194080 cites W1879051445 @default.
• W3012194080 cites W1919431709 @default.
• W3012194080 cites W1964070738 @default.
• W3012194080 cites W1975397402 @default.
• W3012194080 cites W1982154889 @default.
• W3012194080 cites W1982906652 @default.
• W3012194080 cites W1999292190 @default.
• W3012194080 cites W2000307707 @default.
• W3012194080 cites W2012824806 @default.
• W3012194080 cites W2013783679 @default.
• W3012194080 cites W2015598354 @default.
• W3012194080 cites W2018512993 @default.
• W3012194080 cites W2047081963 @default.
• W3012194080 cites W2061730320 @default.
• W3012194080 cites W2064024065 @default.
• W3012194080 cites W2078197314 @default.
• W3012194080 cites W2079242052 @default.
• W3012194080 cites W2084621740 @default.
• W3012194080 cites W2086242172 @default.
• W3012194080 cites W2095869629 @default.
• W3012194080 cites W2131321337 @default.
• W3012194080 cites W2138029572 @default.
• W3012194080 cites W2299321586 @default.
• W3012194080 cites W2544387958 @default.
• W3012194080 cites W2564835664 @default.
• W3012194080 cites W2625856057 @default.
• W3012194080 cites W2786099441 @default.
• W3012194080 cites W2788473137 @default.
• W3012194080 cites W2791839818 @default.
• W3012194080 cites W2796067155 @default.
• W3012194080 cites W2801803191 @default.
• W3012194080 cites W2898314774 @default.
• W3012194080 cites W2905058562 @default.
• W3012194080 cites W2905398573 @default.
• W3012194080 cites W2922304740 @default.
• W3012194080 cites W2928877535 @default.
• W3012194080 cites W2937538955 @default.
• W3012194080 cites W4210955410 @default.
• W3012194080 cites W4232620598 @default.
• W3012194080 doi "https://doi.org/10.1002/cam4.2968" @default.
• W3012194080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7196063" @default.
• W3012194080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32150664" @default.
• W3012194080 hasPublicationYear "2020" @default.
• W3012194080 type Work @default.
• W3012194080 sameAs 3012194080 @default.
• W3012194080 citedByCount "19" @default.
• W3012194080 countsByYear W30121940802021 @default.
• W3012194080 countsByYear W30121940802022 @default.
• W3012194080 countsByYear W30121940802023 @default.
• W3012194080 crossrefType "journal-article" @default.
• W3012194080 hasAuthorship W3012194080A5002747282 @default.
• W3012194080 hasAuthorship W3012194080A5003223330 @default.
• W3012194080 hasAuthorship W3012194080A5004514476 @default.
• W3012194080 hasAuthorship W3012194080A5030330273 @default.
• W3012194080 hasAuthorship W3012194080A5040194968 @default.
• W3012194080 hasAuthorship W3012194080A5042069878 @default.
• W3012194080 hasAuthorship W3012194080A5045138416 @default.
• W3012194080 hasAuthorship W3012194080A5063064112 @default.
• W3012194080 hasAuthorship W3012194080A5072697895 @default.
• W3012194080 hasAuthorship W3012194080A5084445748 @default.
• W3012194080 hasAuthorship W3012194080A5086690723 @default.
• W3012194080 hasAuthorship W3012194080A5090474210 @default.
• W3012194080 hasBestOaLocation W30121940801 @default.
• W3012194080 hasConcept C126322002 @default.
• W3012194080 hasConcept C203014093 @default.
• W3012194080 hasConcept C2522874641 @default.
• W3012194080 hasConcept C2775940106 @default.
• W3012194080 hasConcept C2777214474 @default.
• W3012194080 hasConcept C2777382497 @default.
• W3012194080 hasConcept C2777410769 @default.
• W3012194080 hasConcept C2778019345 @default.
• W3012194080 hasConcept C2780593183 @default.
• W3012194080 hasConcept C2780624289 @default.
• W3012194080 hasConcept C2992208098 @default.
• W3012194080 hasConcept C71924100 @default.
• W3012194080 hasConcept C90924648 @default.
• W3012194080 hasConceptScore W3012194080C126322002 @default.
• W3012194080 hasConceptScore W3012194080C203014093 @default.
• W3012194080 hasConceptScore W3012194080C2522874641 @default.
• W3012194080 hasConceptScore W3012194080C2775940106 @default.

• next