FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012243457> ?p ?o ?g. }

• W3012243457 endingPage "1527" @default.
• W3012243457 startingPage "1516" @default.
• W3012243457 abstract "Supramolecular hydrogels based on inclusion complexation between cyclodextrins (CDs) and polymers have attracted much interest because of their potential for biomedical applications. It is also attractive to incorporate stimuli-responsive properties into the system to create smart hydrogels. Herein, a poly(N-isopropylacrylamide) (PNIPAAm) star polymer with a β-CD core and an adamantyl-terminated poly(ethylene glycol) (Ad-PEG) polymer were synthesized. They self-assembled into a thermoresponsive pseudo-block copolymer through host-guest complexation and formed supramolecular micelles with the change in environment temperature. Subsequently, an injectable polypseudorotaxane-based supramolecular hydrogel was formed between α-CD and the PEG chains of the pseudo-block copolymer. The hydrogel had a unique network structure involving two types of supramolecular self-assemblies between cyclodextrins and polymers, that is, the host-guest complexation between β-CD units and adamantyl groups and the polypseudorotaxane formation between α-CD and PEG chains. We hypothesize that the dual supramolecular hydrogel formed at room temperature may be enhanced by increasing the temperature over the lower critical solution temperature of PNIPAAm because of the hydrophobic interactions of PNIPAAm segments. Furthermore, if the hydrogel is applied for sustained delivery of hydrophobic drugs, the copolymer dissolved from the hydrogel could micellize and continue to serve as micellar drug carriers with the drug encapsulated in the hydrophobic core. Rheological tests revealed that the hydrophobic interactions of the PNIPAAm segments could significantly enhance the strength of the hydrogel when the temperature increased from 25 to 37 °C. As compared to hydrogels formed by α-CD and PEG alone, the sustained release property of this thermoresponsive hydrogel for an anticancer drug, doxorubicin (DOX), improved at 37 °C. The hydrogel dissolved slowly and released the pseudo-block copolymer in the form of micelles that continued to serve as drug carriers with DOX encapsulated in the hydrophobic core, achieving a better cellular uptake and anticancer effect than free DOX controls, even in multidrug-resistant cancer cells. According to these findings, the dual supramolecular hydrogel developed in this work with remarkable thermoresponsive properties might have potential for sustained anticancer drug delivery with enhanced therapeutic effect in multidrug-resistant cancer cells." @default.
• W3012243457 created "2020-03-23" @default.
• W3012243457 creator A5020574039 @default.
• W3012243457 creator A5024783895 @default.
• W3012243457 creator A5027835055 @default.
• W3012243457 creator A5028406995 @default.
• W3012243457 creator A5038133083 @default.
• W3012243457 creator A5038205663 @default.
• W3012243457 creator A5040929731 @default.
• W3012243457 creator A5048508757 @default.
• W3012243457 creator A5076984538 @default.
• W3012243457 date "2020-03-11" @default.
• W3012243457 modified "2023-10-17" @default.
• W3012243457 title "Thermoresponsive Hydrogel Induced by Dual Supramolecular Assemblies and Its Controlled Release Property for Enhanced Anticancer Drug Delivery" @default.
• W3012243457 cites W1967985930 @default.
• W3012243457 cites W1969330428 @default.
• W3012243457 cites W1970412418 @default.
• W3012243457 cites W1972288127 @default.
• W3012243457 cites W1973086131 @default.
• W3012243457 cites W1981051452 @default.
• W3012243457 cites W1981581622 @default.
• W3012243457 cites W1982757587 @default.
• W3012243457 cites W1986167007 @default.
• W3012243457 cites W1988450210 @default.
• W3012243457 cites W1989175743 @default.
• W3012243457 cites W1994717988 @default.
• W3012243457 cites W1994905835 @default.
• W3012243457 cites W1996821701 @default.
• W3012243457 cites W1997143754 @default.
• W3012243457 cites W1997764997 @default.
• W3012243457 cites W2006434892 @default.
• W3012243457 cites W2007857994 @default.
• W3012243457 cites W2013053540 @default.
• W3012243457 cites W2014580754 @default.
• W3012243457 cites W2015491525 @default.
• W3012243457 cites W2015551972 @default.
• W3012243457 cites W2021804758 @default.
• W3012243457 cites W2025616227 @default.
• W3012243457 cites W2030841219 @default.
• W3012243457 cites W2036802125 @default.
• W3012243457 cites W2041268649 @default.
• W3012243457 cites W2042014783 @default.
• W3012243457 cites W2044184859 @default.
• W3012243457 cites W2045383769 @default.
• W3012243457 cites W2046758874 @default.
• W3012243457 cites W2046917186 @default.
• W3012243457 cites W2048893610 @default.
• W3012243457 cites W2050318044 @default.
• W3012243457 cites W2051608289 @default.
• W3012243457 cites W2051684279 @default.
• W3012243457 cites W2056077842 @default.
• W3012243457 cites W2058070602 @default.
• W3012243457 cites W2061628043 @default.
• W3012243457 cites W2073089708 @default.
• W3012243457 cites W2077375276 @default.
• W3012243457 cites W2079796022 @default.
• W3012243457 cites W2081746661 @default.
• W3012243457 cites W2082511674 @default.
• W3012243457 cites W2083161809 @default.
• W3012243457 cites W2086474243 @default.
• W3012243457 cites W2092295229 @default.
• W3012243457 cites W2092700187 @default.
• W3012243457 cites W2094726189 @default.
• W3012243457 cites W2095449486 @default.
• W3012243457 cites W2096103636 @default.
• W3012243457 cites W2101307868 @default.
• W3012243457 cites W2104005229 @default.
• W3012243457 cites W2105260274 @default.
• W3012243457 cites W2106315777 @default.
• W3012243457 cites W2117137267 @default.
• W3012243457 cites W2125527054 @default.
• W3012243457 cites W2126371858 @default.
• W3012243457 cites W2130000193 @default.
• W3012243457 cites W2133059448 @default.
• W3012243457 cites W2144081123 @default.
• W3012243457 cites W2146639342 @default.
• W3012243457 cites W2147032537 @default.
• W3012243457 cites W2159618321 @default.
• W3012243457 cites W2169282607 @default.
• W3012243457 cites W2534441131 @default.
• W3012243457 cites W2554887614 @default.
• W3012243457 cites W2603940552 @default.
• W3012243457 cites W2610816916 @default.
• W3012243457 cites W2756940977 @default.
• W3012243457 cites W2765740442 @default.
• W3012243457 cites W2885009640 @default.
• W3012243457 cites W2920288961 @default.
• W3012243457 cites W2924344396 @default.
• W3012243457 cites W2929033871 @default.
• W3012243457 cites W3192971438 @default.
• W3012243457 cites W4233602835 @default.
• W3012243457 cites W4256413638 @default.
• W3012243457 cites W67572188 @default.
• W3012243457 doi "https://doi.org/10.1021/acs.biomac.0c00077" @default.
• W3012243457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32159339" @default.
• W3012243457 hasPublicationYear "2020" @default.
• W3012243457 type Work @default.
• W3012243457 sameAs 3012243457 @default.

• next