Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012247751> ?p ?o ?g. }
- W3012247751 abstract "Abstract Striatin, a subunit of the serine/threonine phosphatase PP2A, is a core member of the conserved striatin-interacting phosphatase and kinase (STRIPAK) complexes. The protein is expressed in the cell junctions between epithelial cells, which play a role in maintaining cell-cell junctional integrity. Since adhesion is crucial for the function of the mammalian inner ear, we examined the localization and function of striatin in the mouse cochlea. Our results show that in neonatal mice, striatin is specifically expressed in the cell-cell junctions of the inner hair cells, the receptor cells in the mammalian cochlea. Auditory brainstem response measurements of striatin-deficient mice indicated a progressive, high-frequency hearing loss, suggesting that striatin is essential for normal hearing. Moreover, scanning electron micrographs of the organ of Corti revealed a moderate degeneration of the outer hair cells in the middle and basal regions, concordant with the high-frequency hearing loss. Importantly, striatin-deficient mice show aberrant ribbon synapse maturation that may lead to the observed auditory impairment. Together, these results suggest a novel function for striatin in the mammalian auditory system." @default.
- W3012247751 created "2020-03-23" @default.
- W3012247751 creator A5003471479 @default.
- W3012247751 creator A5014306761 @default.
- W3012247751 creator A5016901102 @default.
- W3012247751 creator A5032428752 @default.
- W3012247751 creator A5035957855 @default.
- W3012247751 creator A5036883465 @default.
- W3012247751 creator A5041895242 @default.
- W3012247751 creator A5074055566 @default.
- W3012247751 creator A5084968706 @default.
- W3012247751 date "2020-03-11" @default.
- W3012247751 modified "2023-10-18" @default.
- W3012247751 title "Striatin is required for hearing and affects inner hair cells and ribbon synapses" @default.
- W3012247751 cites W1901305213 @default.
- W3012247751 cites W1964595176 @default.
- W3012247751 cites W1975263056 @default.
- W3012247751 cites W1983983506 @default.
- W3012247751 cites W1999029326 @default.
- W3012247751 cites W2004750199 @default.
- W3012247751 cites W2007989815 @default.
- W3012247751 cites W2026367990 @default.
- W3012247751 cites W2030811160 @default.
- W3012247751 cites W2043250838 @default.
- W3012247751 cites W2044428190 @default.
- W3012247751 cites W2050997148 @default.
- W3012247751 cites W2054493690 @default.
- W3012247751 cites W2065443989 @default.
- W3012247751 cites W2074378742 @default.
- W3012247751 cites W2076174471 @default.
- W3012247751 cites W2077705391 @default.
- W3012247751 cites W2084305313 @default.
- W3012247751 cites W2088581678 @default.
- W3012247751 cites W2093298785 @default.
- W3012247751 cites W2093858065 @default.
- W3012247751 cites W2108812454 @default.
- W3012247751 cites W2110001031 @default.
- W3012247751 cites W2110114499 @default.
- W3012247751 cites W2114237429 @default.
- W3012247751 cites W2115556444 @default.
- W3012247751 cites W2116227658 @default.
- W3012247751 cites W2123007261 @default.
- W3012247751 cites W2136651095 @default.
- W3012247751 cites W2166380239 @default.
- W3012247751 cites W2185555704 @default.
- W3012247751 cites W2199962489 @default.
- W3012247751 cites W2296387621 @default.
- W3012247751 cites W2464971843 @default.
- W3012247751 cites W2576077292 @default.
- W3012247751 cites W2601305951 @default.
- W3012247751 cites W2704380963 @default.
- W3012247751 cites W2738712446 @default.
- W3012247751 cites W2901421008 @default.
- W3012247751 cites W2904336521 @default.
- W3012247751 cites W2906953399 @default.
- W3012247751 cites W2921070741 @default.
- W3012247751 cites W2947342136 @default.
- W3012247751 doi "https://doi.org/10.1101/2020.03.11.987396" @default.
- W3012247751 hasPublicationYear "2020" @default.
- W3012247751 type Work @default.
- W3012247751 sameAs 3012247751 @default.
- W3012247751 citedByCount "2" @default.
- W3012247751 countsByYear W30122477512020 @default.
- W3012247751 crossrefType "posted-content" @default.
- W3012247751 hasAuthorship W3012247751A5003471479 @default.
- W3012247751 hasAuthorship W3012247751A5014306761 @default.
- W3012247751 hasAuthorship W3012247751A5016901102 @default.
- W3012247751 hasAuthorship W3012247751A5032428752 @default.
- W3012247751 hasAuthorship W3012247751A5035957855 @default.
- W3012247751 hasAuthorship W3012247751A5036883465 @default.
- W3012247751 hasAuthorship W3012247751A5041895242 @default.
- W3012247751 hasAuthorship W3012247751A5074055566 @default.
- W3012247751 hasAuthorship W3012247751A5084968706 @default.
- W3012247751 hasBestOaLocation W30122477511 @default.
- W3012247751 hasConcept C105702510 @default.
- W3012247751 hasConcept C11960822 @default.
- W3012247751 hasConcept C130316041 @default.
- W3012247751 hasConcept C148785051 @default.
- W3012247751 hasConcept C178666793 @default.
- W3012247751 hasConcept C2778500370 @default.
- W3012247751 hasConcept C2778585322 @default.
- W3012247751 hasConcept C2780130748 @default.
- W3012247751 hasConcept C2780659331 @default.
- W3012247751 hasConcept C38120836 @default.
- W3012247751 hasConcept C389152 @default.
- W3012247751 hasConcept C41625074 @default.
- W3012247751 hasConcept C55493867 @default.
- W3012247751 hasConcept C86803240 @default.
- W3012247751 hasConcept C95444343 @default.
- W3012247751 hasConceptScore W3012247751C105702510 @default.
- W3012247751 hasConceptScore W3012247751C11960822 @default.
- W3012247751 hasConceptScore W3012247751C130316041 @default.
- W3012247751 hasConceptScore W3012247751C148785051 @default.
- W3012247751 hasConceptScore W3012247751C178666793 @default.
- W3012247751 hasConceptScore W3012247751C2778500370 @default.
- W3012247751 hasConceptScore W3012247751C2778585322 @default.
- W3012247751 hasConceptScore W3012247751C2780130748 @default.
- W3012247751 hasConceptScore W3012247751C2780659331 @default.
- W3012247751 hasConceptScore W3012247751C38120836 @default.
- W3012247751 hasConceptScore W3012247751C389152 @default.