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• W3012261844 endingPage "111960" @default.
• W3012261844 startingPage "111960" @default.
• W3012261844 abstract "Human leukocyte antigen (HLA) class I molecules present antigenic peptides to cytotoxic T cells, causing lysis of malignant cells. Transplantation biology studies have implicated HLA class I molecules in cell migration, but there has been little evidence presented that they influence cancer cell migration, a contributing factor in metastasis. In this study, we examined the effect of HLA-B on pancreatic cancer cell migration. HLA-B siRNA transfection increased the migration of the S2-013 pancreatic cancer cells but, in contrast, reduced migration of the PANC-1 and MIA PaCa-2 pancreatic cancer cell lines. Integrin molecules have previously been implicated in the upregulation of pancreatic cancer cell migration, and knockdown of HLA-B in S2-013 cells heightened the expression of integrin beta 1 (ITGB1), but in the PANC-1 and MIA PaCa-2 cells HLA-B knockdown diminished ITGB1 expression. A transmembrane sequence in an S2-013 HLA-B heavy chain matches a corresponding sequence in HLA-B in the BxPC-3 pancreatic cancer cell line, and knockdown of BxPC-3 HLA-B mimics the effect of S2-013 HLA-B knockdown on migration. In total, our findings indicate that HLA-B influences the expression of ITGB1 in pancreatic cancer cells, with concurrent distinctions in transmembrane sequences and effects on the migration of the cells." @default.
• W3012261844 created "2020-03-23" @default.
• W3012261844 creator A5009892555 @default.
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• W3012261844 creator A5086505077 @default.
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• W3012261844 date "2020-05-01" @default.
• W3012261844 modified "2023-10-01" @default.
• W3012261844 title "HLA-B influences integrin beta-1 expression and pancreatic cancer cell migration" @default.
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• W3012261844 doi "https://doi.org/10.1016/j.yexcr.2020.111960" @default.
• W3012261844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7182497" @default.
• W3012261844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32194036" @default.
• W3012261844 hasPublicationYear "2020" @default.
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