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- W3012306189 abstract "Background: Disruption of β-cell insulin secretion and viability caused by excessive ethanol consumption increases type 2 diabetes mellitus (T2DM) pathogenesis risk. Fibroblast growth factor 21 (FGF21) plays a significant role in regulating lipid and glucose homeostasis. Recently, FGF21, best known for its role in lipid and glucose homeostasis regulation, and its obligate co-receptor β-klotho have been shown to inhibit ethanol ingestion and metabolism. It remains unclear whether heavy ethanol intake modulates islet FGF21 expression and function. This study investigated the relationship between ethanol exposure, FGF21, and islet function in vivo/ex vivo islet and in vitro cell models." @default.
- W3012306189 created "2020-03-23" @default.
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- W3012306189 creator A5024549935 @default.
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- W3012306189 date "2020-03-01" @default.
- W3012306189 modified "2023-10-18" @default.
- W3012306189 title "Alcohol ingestion induces pancreatic islet dysfunction and apoptosis via mediation of FGF21 resistance" @default.
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- W3012306189 doi "https://doi.org/10.21037/atm.2020.02.129" @default.
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