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- W3012314194 abstract "Systemic fungal infections are a growing problem in contemporary medicine and few drugs are licensed for therapy of invasive fungal infections. Differences between fungi and humans, like the presence of a cell wall in fungal cells, can be explored for designing new drugs. (1,3)-β-D-glucan synthase, an enzyme that catalyzes the synthesis of (1,3)-β-D-glucan, a structural and essential component of the fungal cell wall, is absent in mammals and this makes it an excellent target for the development of new antifungal agents. Papulacandins are a family of natural antifungal agents targeting (1,3)-β-D-glucan synthase. In this study we describe the synthesis and biological evaluation of two new Papulacandin analogs as potential (1,3)-β-D-glucan synthase inhibitors." @default.
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- W3012314194 date "2020-01-01" @default.
- W3012314194 modified "2023-09-26" @default.
- W3012314194 title "Synthesis of novel papulacandin D analogs and evaluation of their antifungal potential" @default.
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- W3012314194 doi "https://doi.org/10.1590/s2175-97902019000417652" @default.
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