Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012322913> ?p ?o ?g. }
- W3012322913 abstract "Multidrug resistance (MDR) based on ATP-dependent efflux transporters (p-glycoprotein (p-gp)) remains a major obstacle in successful chemotherapy treatment. Herein, we have investigated the potential of PD-L1 mAb-conjugated nanoliposome to serve as a targeted delivery platform for the co-delivery of paclitaxel (PTX) and p-gp specific transport inhibitor (TQD, tariquidar) in drug-resistant gastric cancers. Two drugs, PTX and TQD, were co-loaded in a single vehicle in a precise ratio to enhance the prospect of combination chemotherapeutic effect. Cellular uptake study indicated that PD-PTLP had higher internalization efficiency in PD-L1 receptor overexpressing SGC7901/ADR cells than non-targeted PTLP. Highest synergy was observed at a weight fraction of 1/0.5 (PTX/TQD) and the combination of PTX and TQD resulted in obvious synergistic effect compared to that of individual drugs alone. Our in vitro results showed that TQD was effective in reversing the multidrug resistance in SGC7901/ADR cells. The IC50 value of PD-PTLP was 0.76 μg/ml compared to 6.58 μg/ml and 7.64 μg/ml for PTX and TQD, respectively. PD-TPLP triggered significantly higher levels of reactive oxygen species (ROS) and cell apoptosis compared to that of free PTX or TQD. Furthermore, the in vivo antitumor study showed that the combination chemotherapy of PD-PTLP displayed a significant inhibition of tumor burden of drug-resistant xenograft tumors with significantly higher terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells. Furthermore, free PTX resulted in significant increase in the levels of AST and ALT while PD-PTLP insignificantly different compared to that of control indicating the safety index. Overall, we believe that combination of anticancer drug with a p-gp inhibitor could provide a potential direction toward the treatment of drug-resistant gastric tumors." @default.
- W3012322913 created "2020-03-23" @default.
- W3012322913 creator A5017029230 @default.
- W3012322913 creator A5026383249 @default.
- W3012322913 creator A5032396875 @default.
- W3012322913 creator A5053624726 @default.
- W3012322913 creator A5060655239 @default.
- W3012322913 creator A5062989133 @default.
- W3012322913 creator A5063890014 @default.
- W3012322913 creator A5076636647 @default.
- W3012322913 creator A5079072243 @default.
- W3012322913 date "2020-03-12" @default.
- W3012322913 modified "2023-10-14" @default.
- W3012322913 title "PD-L1 monoclonal antibody-decorated nanoliposomes loaded with Paclitaxel and P-gp transport inhibitor for the synergistic chemotherapy against multidrug resistant gastric cancers" @default.
- W3012322913 cites W1797447800 @default.
- W3012322913 cites W1964223890 @default.
- W3012322913 cites W1969765578 @default.
- W3012322913 cites W1976269164 @default.
- W3012322913 cites W1983240885 @default.
- W3012322913 cites W2009669778 @default.
- W3012322913 cites W2027748446 @default.
- W3012322913 cites W2030885838 @default.
- W3012322913 cites W2037697797 @default.
- W3012322913 cites W2055397209 @default.
- W3012322913 cites W2064674946 @default.
- W3012322913 cites W2066671159 @default.
- W3012322913 cites W2066864375 @default.
- W3012322913 cites W2076226743 @default.
- W3012322913 cites W2082907765 @default.
- W3012322913 cites W2106530175 @default.
- W3012322913 cites W2106787323 @default.
- W3012322913 cites W2107436374 @default.
- W3012322913 cites W2108615682 @default.
- W3012322913 cites W2108842980 @default.
- W3012322913 cites W2119010359 @default.
- W3012322913 cites W2137450297 @default.
- W3012322913 cites W2152546397 @default.
- W3012322913 cites W2167241428 @default.
- W3012322913 cites W2221837786 @default.
- W3012322913 cites W2272984102 @default.
- W3012322913 cites W2289912760 @default.
- W3012322913 cites W2500588996 @default.
- W3012322913 cites W2519084983 @default.
- W3012322913 cites W2540104635 @default.
- W3012322913 cites W2560367415 @default.
- W3012322913 cites W2594622216 @default.
- W3012322913 cites W2611827085 @default.
- W3012322913 cites W2751226697 @default.
- W3012322913 cites W2902218083 @default.
- W3012322913 doi "https://doi.org/10.1186/s11671-019-3228-z" @default.
- W3012322913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7067943" @default.
- W3012322913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32166458" @default.
- W3012322913 hasPublicationYear "2020" @default.
- W3012322913 type Work @default.
- W3012322913 sameAs 3012322913 @default.
- W3012322913 citedByCount "25" @default.
- W3012322913 countsByYear W30123229132020 @default.
- W3012322913 countsByYear W30123229132021 @default.
- W3012322913 countsByYear W30123229132022 @default.
- W3012322913 countsByYear W30123229132023 @default.
- W3012322913 crossrefType "journal-article" @default.
- W3012322913 hasAuthorship W3012322913A5017029230 @default.
- W3012322913 hasAuthorship W3012322913A5026383249 @default.
- W3012322913 hasAuthorship W3012322913A5032396875 @default.
- W3012322913 hasAuthorship W3012322913A5053624726 @default.
- W3012322913 hasAuthorship W3012322913A5060655239 @default.
- W3012322913 hasAuthorship W3012322913A5062989133 @default.
- W3012322913 hasAuthorship W3012322913A5063890014 @default.
- W3012322913 hasAuthorship W3012322913A5076636647 @default.
- W3012322913 hasAuthorship W3012322913A5079072243 @default.
- W3012322913 hasBestOaLocation W30123229131 @default.
- W3012322913 hasConcept C114851261 @default.
- W3012322913 hasConcept C126322002 @default.
- W3012322913 hasConcept C133936738 @default.
- W3012322913 hasConcept C150903083 @default.
- W3012322913 hasConcept C185592680 @default.
- W3012322913 hasConcept C190283241 @default.
- W3012322913 hasConcept C196795494 @default.
- W3012322913 hasConcept C207001950 @default.
- W3012322913 hasConcept C2776694085 @default.
- W3012322913 hasConcept C2777292972 @default.
- W3012322913 hasConcept C2778707650 @default.
- W3012322913 hasConcept C502942594 @default.
- W3012322913 hasConcept C55493867 @default.
- W3012322913 hasConcept C71924100 @default.
- W3012322913 hasConcept C86803240 @default.
- W3012322913 hasConcept C89423630 @default.
- W3012322913 hasConcept C98274493 @default.
- W3012322913 hasConceptScore W3012322913C114851261 @default.
- W3012322913 hasConceptScore W3012322913C126322002 @default.
- W3012322913 hasConceptScore W3012322913C133936738 @default.
- W3012322913 hasConceptScore W3012322913C150903083 @default.
- W3012322913 hasConceptScore W3012322913C185592680 @default.
- W3012322913 hasConceptScore W3012322913C190283241 @default.
- W3012322913 hasConceptScore W3012322913C196795494 @default.
- W3012322913 hasConceptScore W3012322913C207001950 @default.
- W3012322913 hasConceptScore W3012322913C2776694085 @default.
- W3012322913 hasConceptScore W3012322913C2777292972 @default.
- W3012322913 hasConceptScore W3012322913C2778707650 @default.
- W3012322913 hasConceptScore W3012322913C502942594 @default.