FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012329627> ?p ?o ?g. }

• W3012329627 endingPage "e0230195" @default.
• W3012329627 startingPage "e0230195" @default.
• W3012329627 abstract "Tacrolimus (TAC) is the cornerstone of immunosuppressive therapy in liver transplantation. This study aimed at elucidating the interplay between pharmacogenetic determinants of TAC whole blood and intracellular exposures as well as the pharmacokinetic-pharmacodynamic relationship of TAC in both compartments. Complete pharmacokinetic profiles (Predose, and 20 min, 40 min, 1h, 2h, 3h, 4h, 6h, 8h, 12h post drug intake) of twice daily TAC in whole blood and peripheral blood mononuclear cells (PBMC) were collected in 32 liver transplanted patients in the first ten days post transplantation. A non-parametric population pharmacokinetic model was applied to explore TAC pharmacokinetics in blood and PBMC. Concurrently, calcineurin activity was measured in PBMC. Influence of donor and recipient genetic polymorphisms of ABCB1, CYP3A4 and CYP3A5 on TAC exposure was assessed. Recipient ABCB1 polymorphisms 1199G>A could influence TAC whole blood and intracellular exposure (p<0.05). No association was found between CYP3A4 or CYP3A5 genotypes and TAC whole blood or intracellular concentrations. Finally, intra-PBMC calcineurin activity appeared incompletely inhibited by TAC and less than 50% of patients were expected to achieve intracellular IC50 concentration (100 pg/millions of cells) at therapeutic whole blood concentration (i.e.: 4-10 ng/mL). Together, these data suggest that personalized medicine regarding TAC therapy might be optimized by ABCB1 pharmacogenetic biomarkers and by monitoring intracellular concentration whereas the relationship between intracellular TAC exposure and pharmacodynamics biomarkers more specific than calcineurin activity should be further investigated." @default.
• W3012329627 created "2020-03-23" @default.
• W3012329627 creator A5000394374 @default.
• W3012329627 creator A5004674779 @default.
• W3012329627 creator A5010112260 @default.
• W3012329627 creator A5014869638 @default.
• W3012329627 creator A5015222370 @default.
• W3012329627 creator A5019719279 @default.
• W3012329627 creator A5031891241 @default.
• W3012329627 creator A5038357548 @default.
• W3012329627 creator A5046863866 @default.
• W3012329627 creator A5062249245 @default.
• W3012329627 creator A5066347380 @default.
• W3012329627 creator A5073888362 @default.
• W3012329627 creator A5081103160 @default.
• W3012329627 creator A5089652964 @default.
• W3012329627 date "2020-03-12" @default.
• W3012329627 modified "2023-10-18" @default.
• W3012329627 title "Pharmacogenetic—Whole blood and intracellular pharmacokinetic—Pharmacodynamic (PG-PK2-PD) relationship of tacrolimus in liver transplant recipients" @default.
• W3012329627 cites W1734239245 @default.
• W3012329627 cites W1965390892 @default.
• W3012329627 cites W1967670996 @default.
• W3012329627 cites W1973055702 @default.
• W3012329627 cites W1994924651 @default.
• W3012329627 cites W2004411083 @default.
• W3012329627 cites W2011905159 @default.
• W3012329627 cites W2021298363 @default.
• W3012329627 cites W2025489443 @default.
• W3012329627 cites W2026199383 @default.
• W3012329627 cites W2028704154 @default.
• W3012329627 cites W2033139608 @default.
• W3012329627 cites W2038989721 @default.
• W3012329627 cites W2042361220 @default.
• W3012329627 cites W2065589017 @default.
• W3012329627 cites W2068650301 @default.
• W3012329627 cites W2069583058 @default.
• W3012329627 cites W2080536315 @default.
• W3012329627 cites W2086226953 @default.
• W3012329627 cites W2088079382 @default.
• W3012329627 cites W2090750956 @default.
• W3012329627 cites W2093203053 @default.
• W3012329627 cites W2093748835 @default.
• W3012329627 cites W2098244062 @default.
• W3012329627 cites W2104177803 @default.
• W3012329627 cites W2140806967 @default.
• W3012329627 cites W2142688525 @default.
• W3012329627 cites W2153400906 @default.
• W3012329627 cites W2211846435 @default.
• W3012329627 cites W2310955554 @default.
• W3012329627 cites W2317090998 @default.
• W3012329627 cites W2339616299 @default.
• W3012329627 cites W2487313992 @default.
• W3012329627 cites W2598584096 @default.
• W3012329627 cites W2771076594 @default.
• W3012329627 cites W2789714793 @default.
• W3012329627 cites W2801114593 @default.
• W3012329627 cites W2810210003 @default.
• W3012329627 cites W2886656503 @default.
• W3012329627 cites W2891699974 @default.
• W3012329627 cites W2898261508 @default.
• W3012329627 cites W2899716160 @default.
• W3012329627 cites W2942673049 @default.
• W3012329627 cites W4211179245 @default.
• W3012329627 doi "https://doi.org/10.1371/journal.pone.0230195" @default.
• W3012329627 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7067455" @default.
• W3012329627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32163483" @default.
• W3012329627 hasPublicationYear "2020" @default.
• W3012329627 type Work @default.
• W3012329627 sameAs 3012329627 @default.
• W3012329627 citedByCount "22" @default.
• W3012329627 countsByYear W30123296272020 @default.
• W3012329627 countsByYear W30123296272021 @default.
• W3012329627 countsByYear W30123296272022 @default.
• W3012329627 countsByYear W30123296272023 @default.
• W3012329627 crossrefType "journal-article" @default.
• W3012329627 hasAuthorship W3012329627A5000394374 @default.
• W3012329627 hasAuthorship W3012329627A5004674779 @default.
• W3012329627 hasAuthorship W3012329627A5010112260 @default.
• W3012329627 hasAuthorship W3012329627A5014869638 @default.
• W3012329627 hasAuthorship W3012329627A5015222370 @default.
• W3012329627 hasAuthorship W3012329627A5019719279 @default.
• W3012329627 hasAuthorship W3012329627A5031891241 @default.
• W3012329627 hasAuthorship W3012329627A5038357548 @default.
• W3012329627 hasAuthorship W3012329627A5046863866 @default.
• W3012329627 hasAuthorship W3012329627A5062249245 @default.
• W3012329627 hasAuthorship W3012329627A5066347380 @default.
• W3012329627 hasAuthorship W3012329627A5073888362 @default.
• W3012329627 hasAuthorship W3012329627A5081103160 @default.
• W3012329627 hasAuthorship W3012329627A5089652964 @default.
• W3012329627 hasBestOaLocation W30123296271 @default.
• W3012329627 hasConcept C104317684 @default.
• W3012329627 hasConcept C109650736 @default.
• W3012329627 hasConcept C111113717 @default.
• W3012329627 hasConcept C112705442 @default.
• W3012329627 hasConcept C126322002 @default.
• W3012329627 hasConcept C128057223 @default.
• W3012329627 hasConcept C135763542 @default.
• W3012329627 hasConcept C137061746 @default.

• next